Abstract
Bed rest, both with and without head-down tilt, has been extensively used as an earth-bound analog to study physiologic effects mimicking those occurring in weightlessness during spaceflight. We have been able to show in six subjects that 4 weeks of head-down tilt bed rest induces a significant decrease in interleukin-2 secretion by PHA-stimulated T lymphocytes. Another study, lasting 113 days, with two subjects showed a decreased interleukin-2 receptor expression in PHA-stimulated peripheral blood mononuclear cells but a decreased interleukin-2 production in one subject only. Under the same conditions, interleukin-1 production was largely increased in both subjects. Several other immune parameters were also analyzed. Increased interleukin-1 production could contribute to bone mineral loss encountered during bed rest and decreased interleukin-2 secretion could play a role in the appearance of infectious diseases often observed during bed red.
Original language | English (US) |
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Pages (from-to) | 151-157 |
Number of pages | 7 |
Journal | Journal of Interferon and Cytokine Research |
Volume | 16 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1996 |
ASJC Scopus subject areas
- Immunology
- Cell Biology
- Virology