Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma

Anthony M. D'Amelio; Claudia Monroy; Randa El-Zein; Carol J. Etzel

doi:10.1016/j.leukres.2012.07.014

Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma

Anthony M. D'Amelio, Claudia Monroy, Randa El-Zein, Carol J. Etzel

Epidemiology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.

Original language	English (US)
Pages (from-to)	1359-1364
Number of pages	6
Journal	Leukemia Research
Volume	36
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2012.07.014
State	Published - Nov 2012

Keywords

DNA repair
Haplotypes
Hodgkin lymphoma
Inflammation
Single nucleotide polymorphism

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2012.07.014

Cite this

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title = "Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma",

abstract = "In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.",

keywords = "DNA repair, Haplotypes, Hodgkin lymphoma, Inflammation, Single nucleotide polymorphism",

author = "D'Amelio, {Anthony M.} and Claudia Monroy and Randa El-Zein and Etzel, {Carol J.}",

note = "Funding Information: Our research was supported by a cancer prevention fellowship funded by National Cancer Institute grant K07CA093592, National Cancer Institute grants CA123. Anthony M. D{\textquoteright}Amelio Jr. was also funded through the Marilyn and Frederick R. Lummis Jr, M.D., fellowship in Biomedical Sciences. ",

year = "2012",

month = nov,

doi = "10.1016/j.leukres.2012.07.014",

language = "English (US)",

volume = "36",

pages = "1359--1364",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma

AU - D'Amelio, Anthony M.

AU - Monroy, Claudia

AU - El-Zein, Randa

AU - Etzel, Carol J.

N1 - Funding Information: Our research was supported by a cancer prevention fellowship funded by National Cancer Institute grant K07CA093592, National Cancer Institute grants CA123. Anthony M. D’Amelio Jr. was also funded through the Marilyn and Frederick R. Lummis Jr, M.D., fellowship in Biomedical Sciences.

PY - 2012/11

Y1 - 2012/11

N2 - In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.

AB - In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.

KW - DNA repair

KW - Haplotypes

KW - Hodgkin lymphoma

KW - Inflammation

KW - Single nucleotide polymorphism

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JO - Leukemia Research

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Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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