TY - JOUR
T1 - Using indocyanine green fluorescent lymphography to demonstrate lymphatic architecture
AU - Suami, Hiroo
AU - Chang, David
AU - Skoracki, Roman
AU - Yamada, Kiyoshi
AU - Kimata, Yoshihiro
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Background: Visualisation of the lymphatic system is a challenging task. Recently, an indocyanine green (ICG) fluorescent lymphography system was developed for visualising the lymphatic vessels. ICG emits energy in the near-infrared region between 840 and 850 nm when it is bound to protein in the tissue. Aim: To use ICG fluorescent lymphography to identify locations of the lymphatic vessel for lymphovenous shunt. Methods: The lymphatic anatomy in the upper extremity was investigated using ICG fluorescent lymphography in 3 healthy volunteers and 15 patients with breast cancer-related lymphoedema prior to them undergoing lymphaticovenular bypass. Results: In healthy volunteers, fluorescent images of lymphatic vessels emerged at the dorsal hand as a shiny linear pattern and ran longitudinally towards the proximal arm after a few minutes. In lymphoedema patients, the lymphatic vessels could be identified at the dorsal hand, but the appearance of the lymphatic structure varied between patients. Conclusions: ICG fluorescent lymphography allows for the prompt identification of the lymphatic vessels and has the potential to improve the outcomes of lymphovenous shunt operations and for use as a diagnostic tool.
AB - Background: Visualisation of the lymphatic system is a challenging task. Recently, an indocyanine green (ICG) fluorescent lymphography system was developed for visualising the lymphatic vessels. ICG emits energy in the near-infrared region between 840 and 850 nm when it is bound to protein in the tissue. Aim: To use ICG fluorescent lymphography to identify locations of the lymphatic vessel for lymphovenous shunt. Methods: The lymphatic anatomy in the upper extremity was investigated using ICG fluorescent lymphography in 3 healthy volunteers and 15 patients with breast cancer-related lymphoedema prior to them undergoing lymphaticovenular bypass. Results: In healthy volunteers, fluorescent images of lymphatic vessels emerged at the dorsal hand as a shiny linear pattern and ran longitudinally towards the proximal arm after a few minutes. In lymphoedema patients, the lymphatic vessels could be identified at the dorsal hand, but the appearance of the lymphatic structure varied between patients. Conclusions: ICG fluorescent lymphography allows for the prompt identification of the lymphatic vessels and has the potential to improve the outcomes of lymphovenous shunt operations and for use as a diagnostic tool.
KW - Breast cancer-related lymphoedema
KW - Indocyanine green fluorescent lymphography
KW - Lymphaticovenular shunt operation
KW - Near-infrared radiation
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M3 - Article
AN - SCOPUS:84884583613
SN - 1750-7235
VL - 7
SP - 25
EP - 29
JO - Journal of Lymphoedema
JF - Journal of Lymphoedema
IS - 2
ER -