Using light to probe the brain: Intrinsic signal optical imaging

Ron D. Frostig; Susan A. Masino; Mike C. Kwon; Cynthia H. Chen

doi:10.1002/ima.1850060212

Using light to probe the brain: Intrinsic signal optical imaging

Ron D. Frostig, Susan A. Masino, Mike C. Kwon, Cynthia H. Chen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The theory and application of intrinsic signal optical imaging is described. This in vivo imaging method is based on capturing small activity‐related reflectance changes from the illuminated brain with sensitive cameras. Intrinsic signal imaging excels in the spatial domain (∼50 μ m) and thus enables the visualization of the small, repeated functional domains that are the basis of the functional organization of the cortex in mammals. Recent developments are described, and the advantages and limitations of this imaging method and its relevance of fMRI are discussed.

Original language	English (US)
Pages (from-to)	216-224
Number of pages	9
Journal	International Journal of Imaging Systems and Technology
Volume	6
Issue number	2-3
DOIs	https://doi.org/10.1002/ima.1850060212
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Software
Computer Vision and Pattern Recognition
Electrical and Electronic Engineering

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10.1002/ima.1850060212

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AU - Masino, Susan A.

AU - Kwon, Mike C.

AU - Chen, Cynthia H.

PY - 1995

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Using light to probe the brain: Intrinsic signal optical imaging

Abstract

ASJC Scopus subject areas

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