TY - JOUR
T1 - Uterine leiomyosarcoma a review article
AU - Gockley, Allison A.
AU - Rauh-Hain, J. Alejandro
AU - Del Carmen, Marcela G.
N1 - Publisher Copyright:
Copyright © 2014 by IGCS and ESGO.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Uterine leiomyosarcomas (LMSs) are rare aggressive tumors, with high recurrence rates, even when confined to the uterine corpus at the time of diagnosis. These tumors are large myometrial masses, which typically spread hematogenously. Patients present with vague symptoms similar to those of patients with leiomyomas. Most patients are diagnosed with LMS postoperatively. In the presence of metastatic disease, complete surgical cytoreduction should be attempted when feasible. Lymphadenectomy should be performed only in patients with nodes suspected of harboring metastatic disease and as part of a cytoreductive effort. There are conflicting data to support adjuvant chemotherapy or radiation therapy for early-stage disease. Patients with advanced-stage disease should receive gemcitabine and docetaxel adjuvant chemotherapy. Patients with recurrent disease are candidates for a wide variety of second-line treatments, of which many are investigational. Although prognosis remains dismal, ongoing studies are investigating the role of advanced imaging, multimodality treatment, prognostic nomograms, and unique biomedical pathways to increase understanding of LMS and improve therapeutic options for patients.
AB - Uterine leiomyosarcomas (LMSs) are rare aggressive tumors, with high recurrence rates, even when confined to the uterine corpus at the time of diagnosis. These tumors are large myometrial masses, which typically spread hematogenously. Patients present with vague symptoms similar to those of patients with leiomyomas. Most patients are diagnosed with LMS postoperatively. In the presence of metastatic disease, complete surgical cytoreduction should be attempted when feasible. Lymphadenectomy should be performed only in patients with nodes suspected of harboring metastatic disease and as part of a cytoreductive effort. There are conflicting data to support adjuvant chemotherapy or radiation therapy for early-stage disease. Patients with advanced-stage disease should receive gemcitabine and docetaxel adjuvant chemotherapy. Patients with recurrent disease are candidates for a wide variety of second-line treatments, of which many are investigational. Although prognosis remains dismal, ongoing studies are investigating the role of advanced imaging, multimodality treatment, prognostic nomograms, and unique biomedical pathways to increase understanding of LMS and improve therapeutic options for patients.
KW - Leiomyosarcoma
KW - Review
KW - Uterine tumor
UR - http://www.scopus.com/inward/record.url?scp=84925941277&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925941277&partnerID=8YFLogxK
U2 - 10.1097/IGC.0000000000000290
DO - 10.1097/IGC.0000000000000290
M3 - Review article
C2 - 25304676
AN - SCOPUS:84925941277
SN - 1048-891X
VL - 24
SP - 1538
EP - 1542
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 9
ER -