TY - JOUR
T1 - Utility of biodegradable plasmonic nanoclusters in photoacoustic imaging
AU - Emelianov, Stanislav Y.
AU - Yoon, Soon Joon
AU - Mallidi, Srivalleesha
AU - Tam, Jasmine M.
AU - Tam, Justina O.
AU - Murthy, Avinash
AU - Johnston, Keith P.
AU - Sokolov, Konstantin V.
PY - 2010/11/15
Y1 - 2010/11/15
N2 - Plasmonic metal nanoparticles are used in photoacoustic imaging as contrast agents because of their resonant optical absorption properties in the visible and near-IR regions. However, the nanoparticles could accumulate and result in long-term toxicity in vivo, because they are generally not biodegradable. Recently, biodegradable plasmonic gold nanoclusters, consisting of sub-5 nm primary gold nanoparticles and biodegradable polymer stabilizer, were introduced. In this Letter, we demonstrate the feasibility of biodegradable nanoclusters as a photoacoustic contrast agent. We performed photoacoustic and ultrasound imaging of a tissue-mimicking phantom with inclusions containing nanoclusters at various concentrations. The results indicate that the biodegradable gold nanoclusters can be used as effective contrast agents in photoacoustic imaging.
AB - Plasmonic metal nanoparticles are used in photoacoustic imaging as contrast agents because of their resonant optical absorption properties in the visible and near-IR regions. However, the nanoparticles could accumulate and result in long-term toxicity in vivo, because they are generally not biodegradable. Recently, biodegradable plasmonic gold nanoclusters, consisting of sub-5 nm primary gold nanoparticles and biodegradable polymer stabilizer, were introduced. In this Letter, we demonstrate the feasibility of biodegradable nanoclusters as a photoacoustic contrast agent. We performed photoacoustic and ultrasound imaging of a tissue-mimicking phantom with inclusions containing nanoclusters at various concentrations. The results indicate that the biodegradable gold nanoclusters can be used as effective contrast agents in photoacoustic imaging.
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U2 - 10.1364/OL.35.003751
DO - 10.1364/OL.35.003751
M3 - Article
C2 - 21081985
AN - SCOPUS:78549248496
SN - 0146-9592
VL - 35
SP - 3751
EP - 3753
JO - Optics Letters
JF - Optics Letters
IS - 22
ER -