TY - JOUR
T1 - Utility of chromogranin A, pancreatic polypeptide, glucagon and gastrin in the diagnosis and follow-up of pancreatic neuroendocrine tumours in multiple endocrine neoplasia type 1 patients
AU - Qiu, Wei
AU - Christakis, Ioannis
AU - Silva, Angelica
AU - Bassett, Roland L.
AU - Cao, Liyun
AU - Meng, Qing H.
AU - Gardner Grubbs, Elizabeth
AU - Zhao, Hua
AU - Yao, James C.
AU - Lee, Jeffrey E.
AU - Perrier, Nancy D.
N1 - Publisher Copyright:
© 2016 John Wiley & Sons Ltd
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objective: Pancreatic neuroendocrine tumours (PNETs) are the major source of disease-specific mortality in multiple endocrine neoplasia type 1 (MEN1) patients. Chromogranin A (CgA), pancreatic polypeptide (PP), glucagon and gastrin have some diagnostic value in sporadic PNETs, but there is very little evidence for their efficacy in diagnosing PNETs in MEN1 patients. Design: We performed a retrospective chart review of the existing MEN1 database in our institution. Patients: One hundred and thirteen patients were eligible for diagnostic value analysis of tumour markers. Patients were excluded if measurement of tumour markers was missing, either 3 months prior to PNET diagnosis (PNET patients) or prior to abdominal imaging (non-PNET patients). Measurements: Clinicopathologic characteristics and of tumour marker measurements were analysed. Results: Of 293 confirmed MEN1 cases, 55 PNETs and 58 non-PNETs met inclusion criteria. The area under the curve (AUC) for CgA, PP, glucagon and gastrin in MEN1 cases was 59·5%, 64·1%, 77·0% and 75·9%, respectively. The AUC for the combination of CgA, PP and gastrin was 59·6%. PP, but not CgA, glucagon or gastrin was significantly associated with both age and PNET functional status (P = 0·0485 and 0·0188, respectively). No markers were significantly associated with sex, PNET size, tumour number, tumour location, American Joint Committee on Cancer (AJCC) stage, presence of lymph node metastasis, lymphovascular invasion or overall survival. CgA values were not significantly lower following PNET resection than pre-operatively (P = 0·554). Conclusions: The value of blood markers for diagnosing PNETs in MEN1 patients is relatively low, even when used in combination.
AB - Objective: Pancreatic neuroendocrine tumours (PNETs) are the major source of disease-specific mortality in multiple endocrine neoplasia type 1 (MEN1) patients. Chromogranin A (CgA), pancreatic polypeptide (PP), glucagon and gastrin have some diagnostic value in sporadic PNETs, but there is very little evidence for their efficacy in diagnosing PNETs in MEN1 patients. Design: We performed a retrospective chart review of the existing MEN1 database in our institution. Patients: One hundred and thirteen patients were eligible for diagnostic value analysis of tumour markers. Patients were excluded if measurement of tumour markers was missing, either 3 months prior to PNET diagnosis (PNET patients) or prior to abdominal imaging (non-PNET patients). Measurements: Clinicopathologic characteristics and of tumour marker measurements were analysed. Results: Of 293 confirmed MEN1 cases, 55 PNETs and 58 non-PNETs met inclusion criteria. The area under the curve (AUC) for CgA, PP, glucagon and gastrin in MEN1 cases was 59·5%, 64·1%, 77·0% and 75·9%, respectively. The AUC for the combination of CgA, PP and gastrin was 59·6%. PP, but not CgA, glucagon or gastrin was significantly associated with both age and PNET functional status (P = 0·0485 and 0·0188, respectively). No markers were significantly associated with sex, PNET size, tumour number, tumour location, American Joint Committee on Cancer (AJCC) stage, presence of lymph node metastasis, lymphovascular invasion or overall survival. CgA values were not significantly lower following PNET resection than pre-operatively (P = 0·554). Conclusions: The value of blood markers for diagnosing PNETs in MEN1 patients is relatively low, even when used in combination.
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U2 - 10.1111/cen.13119
DO - 10.1111/cen.13119
M3 - Article
C2 - 27256431
AN - SCOPUS:84982134990
SN - 0300-0664
VL - 85
SP - 400
EP - 407
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 3
ER -