TY - JOUR
T1 - Utility of cyclin D1 in the diagnostic workup of hematopoietic neoplasms
T2 - What can cyclin D1 do for Us?
AU - Wang, Wei
AU - Medeiros, L. Jeffrey
N1 - Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Cyclin D1, encoded by CCND1, promotes cell cycle progression from G1 to S phase. Its expression is induced by MAPK/ERK pathway as well as translocations/rearrangements involving CCND1 gene. The evaluation of cyclin D1 expression by immunohistochemistry plays an important role in the diagnostic workup of various hematopoietic diseases. In this review, we aimed to discuss the value of cyclin D1 immunostain in the diagnosis and different diagnosis of hematopoietic neoplasms.
AB - Cyclin D1, encoded by CCND1, promotes cell cycle progression from G1 to S phase. Its expression is induced by MAPK/ERK pathway as well as translocations/rearrangements involving CCND1 gene. The evaluation of cyclin D1 expression by immunohistochemistry plays an important role in the diagnostic workup of various hematopoietic diseases. In this review, we aimed to discuss the value of cyclin D1 immunostain in the diagnosis and different diagnosis of hematopoietic neoplasms.
KW - cyclin D1
KW - differential diagnosis
KW - hematopoietic neoplasms
UR - http://www.scopus.com/inward/record.url?scp=85068442976&partnerID=8YFLogxK
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U2 - 10.1097/PAP.0000000000000241
DO - 10.1097/PAP.0000000000000241
M3 - Review article
C2 - 31261248
AN - SCOPUS:85068442976
SN - 1072-4109
VL - 26
SP - 281
EP - 291
JO - Advances in anatomic pathology
JF - Advances in anatomic pathology
IS - 5
ER -