Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

F. Vega; M. D. Lozano; J. Alcalde; F. J. Pardo-Mindan

doi:10.1007/s004280050335

Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

F. Vega, M. D. Lozano, J. Alcalde, F. J. Pardo-Mindan

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We report a case of complete lymph node necrosis. No specific aetiology could be determined by morphology, but a B lymphoid population and clonal rearrangement of the immunoglobulin heavy chain gene were demonstrated in immunophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, we suggest that immunohistochemical and gene rearrangement studies may provide additional diagnostic information.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Virchows Archiv
Volume	434
Issue number	3
DOIs	https://doi.org/10.1007/s004280050335
State	Published - 1999
Externally published	Yes

Keywords

Gene rearrangement
Immunohistochemistry
Lymph node necrosis
Malignant lymphoma

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

Access to Document

10.1007/s004280050335

Cite this

@article{e514dac160784c44854a3715a8caf6e9,

title = "Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes",

abstract = "We report a case of complete lymph node necrosis. No specific aetiology could be determined by morphology, but a B lymphoid population and clonal rearrangement of the immunoglobulin heavy chain gene were demonstrated in immunophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, we suggest that immunohistochemical and gene rearrangement studies may provide additional diagnostic information.",

keywords = "Gene rearrangement, Immunohistochemistry, Lymph node necrosis, Malignant lymphoma",

author = "F. Vega and Lozano, {M. D.} and J. Alcalde and Pardo-Mindan, {F. J.}",

year = "1999",

doi = "10.1007/s004280050335",

language = "English (US)",

volume = "434",

pages = "245--248",

journal = "Virchows Archiv",

issn = "0945-6317",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

AU - Vega, F.

AU - Lozano, M. D.

AU - Alcalde, J.

AU - Pardo-Mindan, F. J.

PY - 1999

Y1 - 1999

N2 - We report a case of complete lymph node necrosis. No specific aetiology could be determined by morphology, but a B lymphoid population and clonal rearrangement of the immunoglobulin heavy chain gene were demonstrated in immunophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, we suggest that immunohistochemical and gene rearrangement studies may provide additional diagnostic information.

AB - We report a case of complete lymph node necrosis. No specific aetiology could be determined by morphology, but a B lymphoid population and clonal rearrangement of the immunoglobulin heavy chain gene were demonstrated in immunophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, we suggest that immunohistochemical and gene rearrangement studies may provide additional diagnostic information.

KW - Gene rearrangement

KW - Immunohistochemistry

KW - Lymph node necrosis

KW - Malignant lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0032951021&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032951021&partnerID=8YFLogxK

U2 - 10.1007/s004280050335

DO - 10.1007/s004280050335

M3 - Article

C2 - 10190305

AN - SCOPUS:0032951021

SN - 0945-6317

VL - 434

SP - 245

EP - 248

JO - Virchows Archiv

JF - Virchows Archiv

IS - 3

ER -

Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this