TY - JOUR
T1 - Validating the M. D. Anderson symptom inventory (MDASI) for use in patients with ovarian cancer
AU - Sailors, Mary H.
AU - Bodurka, Diane C.
AU - Gning, Ibrahima
AU - Ramondetta, Lois M.
AU - Williams, Loretta A.
AU - Mendoza, Tito R.
AU - Agarwal, Sonika
AU - Sun, Charlotte C.
AU - Cleeland, Charles S.
N1 - Funding Information:
The authors acknowledge the editorial assistance of Jeanie F. Woodruff, BS, ELS, a scientific editor employed by the Department of Symptom Research at MD Anderson; Ms. Woodruff is supported with departmental funding.
PY - 2013/8
Y1 - 2013/8
N2 - Objective The M. D. Anderson Symptom Inventory (MDASI) captures the severity of common cancer symptoms from the patient's perspective. We describe the validity and sensitivity of a module of the MDASI to be used with patients having ovarian cancer (MDASI-OC). Methods Ovarian cancer-specific module items were developed from 14 qualitative patient interviews. 128 patients with invasive epithelial ovarian, peritoneal, or fallopian-tube cancer treated at The University of Texas MD Anderson Cancer Center were recruited. Patients completed the MDASI-OC, socio-demographic questionnaires, the Functional Assessment of Cancer Therapy-Ovary (FACT-O), and a global quality-of-life (QOL) item. Reliability was assessed using Cronbach α, and sensitivity using a known group was assessed. Construct validity was tested using exploratory factor analysis. Results The sample was primarily white (85.2%), had a mean age of 57.5 years (± 12.7 years), and had previously been treated with chemotherapy (75.0%) and/or surgery (93.8%). Approximately 30% of patients reported disturbed sleep, fatigue, or numbness/tingling of at least moderate severity (≥ 5 on a 0-10 scale). On the ovarian-cancer-specific symptoms, approximately 20% reported back pain, feeling bloated, or constipation of at least moderate severity. Factor analysis revealed six underlying constructs (pain/sleep; cognitive; disease-related and numbness; treatment-related; affective; gastrointestinal-specific). MDASI-OC symptom and interference items had Cronbach α values of 0.90 and 0.89, respectively. The MDASI-OC was sensitive to symptom severity by performance status (p = 0.009), QOL (p = 0.002), and FACT-O scores (p < 0.001). Conclusions The 27-item MDASI-OC meets common criteria for validation and reliability and is sensitive to expected changes in symptoms related to differences in disease and treatment status.
AB - Objective The M. D. Anderson Symptom Inventory (MDASI) captures the severity of common cancer symptoms from the patient's perspective. We describe the validity and sensitivity of a module of the MDASI to be used with patients having ovarian cancer (MDASI-OC). Methods Ovarian cancer-specific module items were developed from 14 qualitative patient interviews. 128 patients with invasive epithelial ovarian, peritoneal, or fallopian-tube cancer treated at The University of Texas MD Anderson Cancer Center were recruited. Patients completed the MDASI-OC, socio-demographic questionnaires, the Functional Assessment of Cancer Therapy-Ovary (FACT-O), and a global quality-of-life (QOL) item. Reliability was assessed using Cronbach α, and sensitivity using a known group was assessed. Construct validity was tested using exploratory factor analysis. Results The sample was primarily white (85.2%), had a mean age of 57.5 years (± 12.7 years), and had previously been treated with chemotherapy (75.0%) and/or surgery (93.8%). Approximately 30% of patients reported disturbed sleep, fatigue, or numbness/tingling of at least moderate severity (≥ 5 on a 0-10 scale). On the ovarian-cancer-specific symptoms, approximately 20% reported back pain, feeling bloated, or constipation of at least moderate severity. Factor analysis revealed six underlying constructs (pain/sleep; cognitive; disease-related and numbness; treatment-related; affective; gastrointestinal-specific). MDASI-OC symptom and interference items had Cronbach α values of 0.90 and 0.89, respectively. The MDASI-OC was sensitive to symptom severity by performance status (p = 0.009), QOL (p = 0.002), and FACT-O scores (p < 0.001). Conclusions The 27-item MDASI-OC meets common criteria for validation and reliability and is sensitive to expected changes in symptoms related to differences in disease and treatment status.
KW - Ovarian cancer MDASI M. D. Anderson Symptom Inventory Symptoms Assessment Validation
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U2 - 10.1016/j.ygyno.2013.05.009
DO - 10.1016/j.ygyno.2013.05.009
M3 - Article
C2 - 23685012
AN - SCOPUS:84880280444
SN - 0090-8258
VL - 130
SP - 323
EP - 328
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 2
ER -