Abstract
Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.
Original language | English (US) |
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Pages (from-to) | 6716-6720 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 579 |
Issue number | 30 |
DOIs | |
State | Published - Dec 19 2005 |
Keywords
- Heat shock protein
- Hsp70
- Neuroprotection
- Phospho-p44/42 mitogen-activated protein kinase
- Valproic acid
- p-Akt
- p-B cell lymphoma protein-2
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology