Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia

E. Estey; W. Plunkett; D. Dixon; M. Keating; K. McCredie; E. J. Freireich

Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia

E. Estey, W. Plunkett, D. Dixon, M. Keating, K. McCredie, E. J. Freireich

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Abstract

The cytotoxic effect of cytosine arabinoside (ara-C) is presumably mediated by cytosine arabinoside 5'-triphosphate (ara-CTP). We tested for a correlation between intracellular ara-CTP pharmacokinetics and clinical response among 51 patients who received high dose ara-C (3 g/m² at 12-hr intervals) as therapy for refractory acute leukemia. After accounting for pretreatment clinical variables that correlated with response, measurement of ara-CTP pharmacokinetics added significant prognostic information. This provides a rationale for manipulation of schedules of high dose ara-C administration in those patients whose pharmacokinetic characteristics are inconsistent with response to an every 12-hr schedule.

Original language	English (US)
Pages (from-to)	580-583
Number of pages	4
Journal	Leukemia
Volume	1
Issue number	8
State	Published - 1987

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Cite this

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abstract = "The cytotoxic effect of cytosine arabinoside (ara-C) is presumably mediated by cytosine arabinoside 5'-triphosphate (ara-CTP). We tested for a correlation between intracellular ara-CTP pharmacokinetics and clinical response among 51 patients who received high dose ara-C (3 g/m2 at 12-hr intervals) as therapy for refractory acute leukemia. After accounting for pretreatment clinical variables that correlated with response, measurement of ara-CTP pharmacokinetics added significant prognostic information. This provides a rationale for manipulation of schedules of high dose ara-C administration in those patients whose pharmacokinetic characteristics are inconsistent with response to an every 12-hr schedule.",

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T1 - Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia

AU - Estey, E.

AU - Plunkett, W.

AU - Dixon, D.

AU - Keating, M.

AU - McCredie, K.

AU - Freireich, E. J.

PY - 1987

Y1 - 1987

N2 - The cytotoxic effect of cytosine arabinoside (ara-C) is presumably mediated by cytosine arabinoside 5'-triphosphate (ara-CTP). We tested for a correlation between intracellular ara-CTP pharmacokinetics and clinical response among 51 patients who received high dose ara-C (3 g/m2 at 12-hr intervals) as therapy for refractory acute leukemia. After accounting for pretreatment clinical variables that correlated with response, measurement of ara-CTP pharmacokinetics added significant prognostic information. This provides a rationale for manipulation of schedules of high dose ara-C administration in those patients whose pharmacokinetic characteristics are inconsistent with response to an every 12-hr schedule.

AB - The cytotoxic effect of cytosine arabinoside (ara-C) is presumably mediated by cytosine arabinoside 5'-triphosphate (ara-CTP). We tested for a correlation between intracellular ara-CTP pharmacokinetics and clinical response among 51 patients who received high dose ara-C (3 g/m2 at 12-hr intervals) as therapy for refractory acute leukemia. After accounting for pretreatment clinical variables that correlated with response, measurement of ara-CTP pharmacokinetics added significant prognostic information. This provides a rationale for manipulation of schedules of high dose ara-C administration in those patients whose pharmacokinetic characteristics are inconsistent with response to an every 12-hr schedule.

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AN - SCOPUS:0023470734

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JF - Leukemia

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Variables predicting response to high dose cytosine arabinoside therapy in patients with refractory acute leukemia

Abstract

ASJC Scopus subject areas

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