VeriStrat® classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab

David P. Carbone; J. Stuart Salmon; Dean Billheimer; Heidi Chen; Alan Sandler; Heinrich Roder; Joanna Roder; Maxim Tsypin; Roy S. Herbst; Anne S. Tsao; Hai T. Tran; Thao P. Dang

doi:10.1016/j.lungcan.2009.11.019

VeriStrat^® classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab

David P. Carbone, J. Stuart Salmon, Dean Billheimer, Heidi Chen, Alan Sandler, Heinrich Roder, Joanna Roder, Maxim Tsypin, Roy S. Herbst, Anne S. Tsao, Hai T. Tran, Thao P. Dang

Thoracic Head & Neck Medical Oncology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We applied an established and commercially available serum proteomic classifier for survival after treatment with erlotinib (VeriStrat^®) in a blinded manner to pretreatment sera obtained from recurrent advanced NSCLC patients before treatment with the combination of erlotinib plus bevacizumab. We found that VeriStrat^® could classify these patients into two groups with significantly better or worse outcomes and may enable rational selection of patients more likely to benefit from this costly and potentially toxic regimen.

Original language	English (US)
Pages (from-to)	337-340
Number of pages	4
Journal	Lung Cancer
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/j.lungcan.2009.11.019
State	Published - Sep 2010

Keywords

Bevacizumab
Erlotinib
Lung cancer
Personalized therapy
Proteomics
Serum biomarker

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

Access to Document

10.1016/j.lungcan.2009.11.019

Cite this

Carbone, D. P., Salmon, J. S., Billheimer, D., Chen, H., Sandler, A., Roder, H., Roder, J., Tsypin, M., Herbst, R. S., Tsao, A. S., Tran, H. T., & Dang, T. P. (2010). VeriStrat^® classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab. Lung Cancer, 69(3), 337-340. https://doi.org/10.1016/j.lungcan.2009.11.019

Carbone, DP, Salmon, JS, Billheimer, D, Chen, H, Sandler, A, Roder, H, Roder, J, Tsypin, M, Herbst, RS, Tsao, AS , Tran, HT & Dang, TP 2010, 'VeriStrat^® classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab', Lung Cancer, vol. 69, no. 3, pp. 337-340. https://doi.org/10.1016/j.lungcan.2009.11.019

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abstract = "We applied an established and commercially available serum proteomic classifier for survival after treatment with erlotinib (VeriStrat{\textregistered}) in a blinded manner to pretreatment sera obtained from recurrent advanced NSCLC patients before treatment with the combination of erlotinib plus bevacizumab. We found that VeriStrat{\textregistered} could classify these patients into two groups with significantly better or worse outcomes and may enable rational selection of patients more likely to benefit from this costly and potentially toxic regimen.",

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AU - Carbone, David P.

AU - Salmon, J. Stuart

AU - Billheimer, Dean

AU - Chen, Heidi

AU - Sandler, Alan

AU - Roder, Heinrich

AU - Roder, Joanna

AU - Tsypin, Maxim

AU - Herbst, Roy S.

AU - Tsao, Anne S.

AU - Tran, Hai T.

AU - Dang, Thao P.

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KW - Personalized therapy

KW - Proteomics

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