Vesicle adhesion reveals novel universal relationships for biophysical characterization

Ehsan Irajizad; Ashutosh Agrawal

doi:10.1007/s10237-017-0947-x

Vesicle adhesion reveals novel universal relationships for biophysical characterization

Ehsan Irajizad, Ashutosh Agrawal

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.

Original language	English (US)
Pages (from-to)	103-109
Number of pages	7
Journal	Biomechanics and Modeling in Mechanobiology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/s10237-017-0947-x
State	Published - Feb 2018
Externally published	Yes

Keywords

Adhesion energy
Lipid membranes
Nanoparticle stiffness
Vesicle adhesion

ASJC Scopus subject areas

Biotechnology
Modeling and Simulation
Mechanical Engineering

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abstract = "Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.",

keywords = "Adhesion energy, Lipid membranes, Nanoparticle stiffness, Vesicle adhesion",

author = "Ehsan Irajizad and Ashutosh Agrawal",

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AU - Agrawal, Ashutosh

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PY - 2018/2

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N2 - Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.

AB - Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle–substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.

KW - Adhesion energy

KW - Lipid membranes

KW - Nanoparticle stiffness

KW - Vesicle adhesion

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Vesicle adhesion reveals novel universal relationships for biophysical characterization

Abstract

Keywords

ASJC Scopus subject areas

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