TY - JOUR
T1 - Vindesine in the treatment of refractory breast cancer
T2 - Improvement in therapeutic index with continuous 5-day infusion
AU - Yap, H. Y.
AU - Blumenschein, G. R.
AU - Bodey, G. P.
AU - Hortobagyi, G. N.
AU - Buzdar, A. U.
AU - DiStefano, A.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 1981
Y1 - 1981
N2 - Sixty patients with metastatic breast cancer refractory to prior doxorubicin combinations were randomized by performance status, dominant disease site, and number of involved organ sites to receive vindesine either as a bolus injection of 3-4 mg/m 2 iv every 10-14 days or as a continuous 5-day infusion of 1-1.2 mg/m 2/day every 21 days. There were two patients with partial responses (7%) and six with stable disease among the 26 evaluable patients who received bolus injections. Of the 25 evaluable patients who received continuous infusions, seven achieved a partial response (28%) and 11 had stable disease (0.001<P<0.005). Thirteen patients, after failing to respond to bolus vindesine, were given continuous infusions. Of these, 11 were evaluable and four had partial responses (36%). Responses were seen in all organ sites of involvement, with response duration ranging from 2 to 9+ months. Side effects included nausea, vomiting, stomatitis, constipation, neuropathy, fever, and myelosuppression. Except for myelosuppression, which was more evident with the continuous infusion schedule, no significant difference was seen in the frequency of side effects encountered with the two schedules. These results confirmed that there is an improved therapeutic index for vindesine when it is given as a continuous 5-day infusion.
AB - Sixty patients with metastatic breast cancer refractory to prior doxorubicin combinations were randomized by performance status, dominant disease site, and number of involved organ sites to receive vindesine either as a bolus injection of 3-4 mg/m 2 iv every 10-14 days or as a continuous 5-day infusion of 1-1.2 mg/m 2/day every 21 days. There were two patients with partial responses (7%) and six with stable disease among the 26 evaluable patients who received bolus injections. Of the 25 evaluable patients who received continuous infusions, seven achieved a partial response (28%) and 11 had stable disease (0.001<P<0.005). Thirteen patients, after failing to respond to bolus vindesine, were given continuous infusions. Of these, 11 were evaluable and four had partial responses (36%). Responses were seen in all organ sites of involvement, with response duration ranging from 2 to 9+ months. Side effects included nausea, vomiting, stomatitis, constipation, neuropathy, fever, and myelosuppression. Except for myelosuppression, which was more evident with the continuous infusion schedule, no significant difference was seen in the frequency of side effects encountered with the two schedules. These results confirmed that there is an improved therapeutic index for vindesine when it is given as a continuous 5-day infusion.
UR - http://www.scopus.com/inward/record.url?scp=0019465771&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019465771&partnerID=8YFLogxK
M3 - Article
C2 - 7273012
AN - SCOPUS:0019465771
SN - 0361-5960
VL - 65
SP - 775
EP - 779
JO - Cancer Treatment Reports
JF - Cancer Treatment Reports
IS - 9-10
ER -