TY - JOUR
T1 - Vitamin supplementation and reduced risk of basal cell carcinoma
AU - Wei, Qingyi
AU - Matanoski, Genevieve M.
AU - Farmer, Evan R.
AU - Strickland, Paul
AU - Grossman, Lawrence
N1 - Funding Information:
Acknowledgements-The authors would like to thank Drs Margaret Spitz, Christopher Amos, Elizabeth Whitmore for their critical comments and suggestions, Dr Maureen Goode for her scientific editing, Mr Mohammad Hedayati for his assistance in laboratory work, and MS Deborah Lantry for her contributions to the recruitment of subjects. This research was supported by National Institutes of Health grant ROl-GM31110 to L.C. and by National Institute of Environmental Health grant P30-ES03819 to G.M.M. This paper was presented at the Annual Meeting of the American Society of Preventive Oncology, 20-23 March, 1993, Tucson, Arizona.
PY - 1994/8
Y1 - 1994/8
N2 - A clinic-based case-control study was conducted to determine the association between vitamin supplement use and risk of basal cell carcinoma (BCC) of the skin. The subjects were 131 patients with histopathologically confirmed primary BCC and 200 cancer-free controls with non-premalignant skin disorders. Use of any vitamins (mainly multivitamins and vitamins A, C, and E) was associated with reduced risk of BCC. After controlling for age, sex, cigarette smoking, number of lifetime severe sunburns, and skin actinic elastosis, regular vitamin supplementation was associated with a significantly reduced risk of BCC (odds ratio (OR) = 0.3; 95% confidence interval (CI) = 0.2-0.6). The ORs decreased as the regularity (p < 0.001) and daily doses of supplement used increased, especially for vitamins A (p < 0.005) and E (p < 0.005). Vitamin supplementation was not associated with alterations in cellular DNA repair. These results, however, cannot be considered conclusive because of the relatively low participation rates ( 131 830 for cases and 200 1406 for controls) due to the requirement of blood donation and more rigorous studies are needed to clarify the effect of supplemental vitamins, particularly of vitamins A and E, on the risk of BCC of the skin.
AB - A clinic-based case-control study was conducted to determine the association between vitamin supplement use and risk of basal cell carcinoma (BCC) of the skin. The subjects were 131 patients with histopathologically confirmed primary BCC and 200 cancer-free controls with non-premalignant skin disorders. Use of any vitamins (mainly multivitamins and vitamins A, C, and E) was associated with reduced risk of BCC. After controlling for age, sex, cigarette smoking, number of lifetime severe sunburns, and skin actinic elastosis, regular vitamin supplementation was associated with a significantly reduced risk of BCC (odds ratio (OR) = 0.3; 95% confidence interval (CI) = 0.2-0.6). The ORs decreased as the regularity (p < 0.001) and daily doses of supplement used increased, especially for vitamins A (p < 0.005) and E (p < 0.005). Vitamin supplementation was not associated with alterations in cellular DNA repair. These results, however, cannot be considered conclusive because of the relatively low participation rates ( 131 830 for cases and 200 1406 for controls) due to the requirement of blood donation and more rigorous studies are needed to clarify the effect of supplemental vitamins, particularly of vitamins A and E, on the risk of BCC of the skin.
KW - Basal cell carcinoma
KW - Case-control study
KW - Vitamin
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U2 - 10.1016/0895-4356(94)90185-6
DO - 10.1016/0895-4356(94)90185-6
M3 - Article
C2 - 7730885
AN - SCOPUS:0027967004
SN - 0895-4356
VL - 47
SP - 829
EP - 836
JO - Journal of clinical epidemiology
JF - Journal of clinical epidemiology
IS - 8
ER -