TY - JOUR
T1 - Water soluble DACHPt(II) complexes
T2 - Problems of purification; Stability of complexes with nitrogen-containing ligands
AU - Roberts, John D.
AU - Schmidt, Wendelyn J.
AU - Tong, William P.
AU - Hacker, Miles P.
N1 - Funding Information:
Nicholas P. Farrell, Ph.D. was frequently consulted in the course of these investigations. Technical assistance was provided by Ms. Linda Matthews, Ms. Mary Gundel, Ms. Donna Kiley, and Mr. Gary Ross. Supported by grants from the American Cancer Society (86-8) and the National Cancer Institute (U.S.A.) (CA 32244 and CA 22435).
PY - 1988/10
Y1 - 1988/10
N2 - Two previously reported water soluble 1,2-diaminocyclohexaneplatinum(II) antitumor complexes with nitrogen-containing dicarboxylato ligands (N-substituted iminodiacetato(1,2-diaminocyclohexane)platinum(II) and aminomalonato(1,2-diaminocyclohexane)platinum(II)) were discovered to have significant residual impurities in the chemical formulations. Upon further purification each complex was found to be significantly less active in biological systems than previously reported. Each complex is stable in aqueous solution. This experience suggests that commonly accepted criteria for chemical identification and purity are inadequate for this type of complex. We hypothesize that tridentate bonding between the nitrogen-containing dicarboxylato group and platinum renders these complexes chemically stable and biologically inert.
AB - Two previously reported water soluble 1,2-diaminocyclohexaneplatinum(II) antitumor complexes with nitrogen-containing dicarboxylato ligands (N-substituted iminodiacetato(1,2-diaminocyclohexane)platinum(II) and aminomalonato(1,2-diaminocyclohexane)platinum(II)) were discovered to have significant residual impurities in the chemical formulations. Upon further purification each complex was found to be significantly less active in biological systems than previously reported. Each complex is stable in aqueous solution. This experience suggests that commonly accepted criteria for chemical identification and purity are inadequate for this type of complex. We hypothesize that tridentate bonding between the nitrogen-containing dicarboxylato group and platinum renders these complexes chemically stable and biologically inert.
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U2 - 10.1016/S0020-1693(00)83870-0
DO - 10.1016/S0020-1693(00)83870-0
M3 - Article
AN - SCOPUS:0040358386
SN - 0020-1693
VL - 153
SP - 123
EP - 127
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
IS - 2
ER -