TY - JOUR
T1 - When DNA Polymerases Multitask
T2 - Functions Beyond Nucleotidyl Transfer
AU - Carvajal-Maldonado, Denisse
AU - Drogalis Beckham, Lea
AU - Wood, Richard D.
AU - Doublié, Sylvie
N1 - Publisher Copyright:
Copyright © 2022 Carvajal-Maldonado, Drogalis Beckham, Wood and Doublié.
PY - 2022/1/7
Y1 - 2022/1/7
N2 - DNA polymerases catalyze nucleotidyl transfer, the central reaction in synthesis of DNA polynucleotide chains. They function not only in DNA replication, but also in diverse aspects of DNA repair and recombination. Some DNA polymerases can perform translesion DNA synthesis, facilitating damage tolerance and leading to mutagenesis. In addition to these functions, many DNA polymerases conduct biochemically distinct reactions. This review presents examples of DNA polymerases that carry out nuclease (3ʹ—5′ exonuclease, 5′ nuclease, or end-trimming nuclease) or lyase (5′ dRP lyase) extracurricular activities. The discussion underscores how DNA polymerases have a remarkable ability to manipulate DNA strands, sometimes involving relatively large intramolecular movement.
AB - DNA polymerases catalyze nucleotidyl transfer, the central reaction in synthesis of DNA polynucleotide chains. They function not only in DNA replication, but also in diverse aspects of DNA repair and recombination. Some DNA polymerases can perform translesion DNA synthesis, facilitating damage tolerance and leading to mutagenesis. In addition to these functions, many DNA polymerases conduct biochemically distinct reactions. This review presents examples of DNA polymerases that carry out nuclease (3ʹ—5′ exonuclease, 5′ nuclease, or end-trimming nuclease) or lyase (5′ dRP lyase) extracurricular activities. The discussion underscores how DNA polymerases have a remarkable ability to manipulate DNA strands, sometimes involving relatively large intramolecular movement.
KW - DNA polymerases
KW - DNA repair
KW - lyase activity
KW - nuclease activity
KW - nucleotidyl transfer
KW - proofreading
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U2 - 10.3389/fmolb.2021.815845
DO - 10.3389/fmolb.2021.815845
M3 - Review article
C2 - 35071329
AN - SCOPUS:85123222023
SN - 2296-889X
VL - 8
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
M1 - 815845
ER -