Abstract
Objectives: Older men with a prostate cancer (PCa) diagnosis face competing mortality risks. Little is known about the prevalence of vulnerability and predictors of mortality in this population compared to men without a PCa diagnosis. We examined the predictive utility of the Vulnerable Elders Survey (VES-13) for mortality in older men with a PCa diagnosis as compared to controls. Materials and Methods: Men aged ≥ 65 years from an urban geriatrics clinic completed the VES-13 between 2003 and 2008. Each patient with a PCa diagnosis was matched by age to five controls, resulting in 59 patients with a PCa diagnosis and 318 controls. Cox proportional hazard models were used to determine the association of a PCa diagnosis and vulnerability on the VES-13 with mortality. Results and Conclusions: The mean age for men with a PCa diagnosis and controls was 77.9 years and 76.1 years, respectively. Of those with a PCa diagnosis, 74.6% had no active disease or a rising PSA only. Regardless of PCa diagnosis, vulnerable individuals on the VES-13 were more likely to die during the study period (VES-13 ≥ 3: HR = 4.46, p < 0.01; VES13 ≥ 6: HR = 3.77, p < 0.01). Men with a PCa diagnosis were not more likely to die compared to age-matched controls (VES-13 ≥ 3: HR = 1.14, p = 0.59; VES13 ≥ 6: HR = 1.06, p = 0.83). Vulnerability for men with a PCa diagnosis was more predictive of mortality. Therefore, the assessment of vulnerability is important for establishing goals of care.
Original language | English (US) |
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Pages (from-to) | 437-443 |
Number of pages | 7 |
Journal | Journal of Geriatric Oncology |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2016 |
Externally published | Yes |
Keywords
- Mortality
- Prostate cancer
- Vulnerability
ASJC Scopus subject areas
- Oncology
- Geriatrics and Gerontology