Abstract
Rapid in situ determination of surgical resection margins during breast cancer surgery would reduce patient time under anesthesia. We present preliminary data supporting the use of a fluorescent glucose analog (2-NBDG) as an optical contrast agent to differentiate freshly excised breast tissue containing cancerous cells from normal breast tissue. Multi-spectral images of 14 breast cancer specimens acquired before and after incubation with 2-NBDG demonstrated increased fluorescent signal in all of the malignant tissue due to increased 2-NBDG consumption. We demonstrate that 2-NBDG has potential as an optical contrast agent to differentiate cancerous from non-cancerous tissue.
Original language | English (US) |
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Pages (from-to) | 1514-1523 |
Number of pages | 10 |
Journal | Biomedical Optics Express |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - 2011 |
ASJC Scopus subject areas
- Biotechnology
- Atomic and Molecular Physics, and Optics