TY - JOUR
T1 - Wnt signaling in cancer
T2 - therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
AU - Jung, Youn-Sang
AU - Park, Jae Il
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.
AB - Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.
UR - http://www.scopus.com/inward/record.url?scp=85079437639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079437639&partnerID=8YFLogxK
U2 - 10.1038/s12276-020-0380-6
DO - 10.1038/s12276-020-0380-6
M3 - Review article
C2 - 32037398
AN - SCOPUS:85079437639
SN - 1226-3613
VL - 52
SP - 183
EP - 191
JO - Experimental and Molecular Medicine
JF - Experimental and Molecular Medicine
IS - 2
ER -