TY - JOUR
T1 - Wnt signaling in liver regeneration, disease, and cancer
AU - Zou, Gengyi
AU - Park, Jae Il
N1 - Funding Information:
We apologize for not including all relevant studies in the field due to limited space. This work was supported by the Cancer Prevention and Research Institute of Texas (RP200315 to J.I.P.) and the National Cancer Institute (CA193297 and CA256207 to J.I.P.).
Publisher Copyright:
© 2023 by Korean Association for the Study of the Liver.
PY - 2023/1
Y1 - 2023/1
N2 - The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. In this review, we discussed the role of Wnt signaling in liver regeneration, precancerous lesion, and liver cancer. Furthermore, we summarized the basic and clinical approaches of Wnt signaling blockade and proposed the therapeutic prospects of cancer-specific Wnt signaling blockade for liver cancer treatment.
AB - The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. In this review, we discussed the role of Wnt signaling in liver regeneration, precancerous lesion, and liver cancer. Furthermore, we summarized the basic and clinical approaches of Wnt signaling blockade and proposed the therapeutic prospects of cancer-specific Wnt signaling blockade for liver cancer treatment.
KW - Hepatocellular carcinoma
KW - Liver diseases
KW - Liver regeneration
KW - WNT signaling pathway
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U2 - 10.3350/cmh.2022.0058
DO - 10.3350/cmh.2022.0058
M3 - Review article
C2 - 35785913
AN - SCOPUS:85146182936
SN - 2287-2728
VL - 29
SP - 33
EP - 50
JO - Clinical and Molecular Hepatology
JF - Clinical and Molecular Hepatology
IS - 1
ER -