Wnt to build a tube: Contributions of Wnt signaling to epithelial tubulogenesis

Rachel K. Miller; Pierre D. McCrea

doi:10.1002/dvdy.22059

Wnt to build a tube: Contributions of Wnt signaling to epithelial tubulogenesis

Rachel K. Miller, Pierre D. McCrea

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Epithelial tubes are crucial to the function of organ systems including the cardiovascular system, pulmonary system, gastrointestinal tract, reproductive organ systems, excretory system, and auditory system. Using a variety of animal model systems, recent studies have substantiated the role of Wnt signaling via the canonical/β-catenin-mediated trajectory, the non-canonical Wnt trajectories, or both, in forming epithelial tubular tissues. This review focuses on the involvement of the Wnt pathways in the induction, specification, proliferation, and morphogenesis involved in tubulogenesis within tissues including the lungs, kidneys, ears, mammary glands, gut, and heart. The ultimate goal is to describe the developmental processes forming the various tubulogenic organ systems to determine the relationships between these processes.

Original language	English (US)
Pages (from-to)	77-93
Number of pages	17
Journal	Developmental Dynamics
Volume	239
Issue number	1
DOIs	https://doi.org/10.1002/dvdy.22059
State	Published - Jan 2010

Keywords

Calcium
Cochlea
Convergent extension
Ear
Gastrulation
Gut
Heart
Kidney
Lung
Mammary
Neurulation
PCP
Planar cell polarity
Tubule
Tubulogenesis
Wnt
β-catenin

ASJC Scopus subject areas

Developmental Biology

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10.1002/dvdy.22059

Cite this

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title = "Wnt to build a tube: Contributions of Wnt signaling to epithelial tubulogenesis",

abstract = "Epithelial tubes are crucial to the function of organ systems including the cardiovascular system, pulmonary system, gastrointestinal tract, reproductive organ systems, excretory system, and auditory system. Using a variety of animal model systems, recent studies have substantiated the role of Wnt signaling via the canonical/β-catenin-mediated trajectory, the non-canonical Wnt trajectories, or both, in forming epithelial tubular tissues. This review focuses on the involvement of the Wnt pathways in the induction, specification, proliferation, and morphogenesis involved in tubulogenesis within tissues including the lungs, kidneys, ears, mammary glands, gut, and heart. The ultimate goal is to describe the developmental processes forming the various tubulogenic organ systems to determine the relationships between these processes.",

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AB - Epithelial tubes are crucial to the function of organ systems including the cardiovascular system, pulmonary system, gastrointestinal tract, reproductive organ systems, excretory system, and auditory system. Using a variety of animal model systems, recent studies have substantiated the role of Wnt signaling via the canonical/β-catenin-mediated trajectory, the non-canonical Wnt trajectories, or both, in forming epithelial tubular tissues. This review focuses on the involvement of the Wnt pathways in the induction, specification, proliferation, and morphogenesis involved in tubulogenesis within tissues including the lungs, kidneys, ears, mammary glands, gut, and heart. The ultimate goal is to describe the developmental processes forming the various tubulogenic organ systems to determine the relationships between these processes.

KW - Calcium

KW - Cochlea

KW - Convergent extension

KW - Ear

KW - Gastrulation

KW - Gut

KW - Heart

KW - Kidney

KW - Lung

KW - Mammary

KW - Neurulation

KW - PCP

KW - Planar cell polarity

KW - Tubule

KW - Tubulogenesis

KW - Wnt

KW - β-catenin

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ER -

Wnt to build a tube: Contributions of Wnt signaling to epithelial tubulogenesis

Abstract

Keywords

ASJC Scopus subject areas

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