Women with HNPCC: A target population for the chemoprevention of gynecologic cancers

Russell R. Broaddus; Karen H. Lu

doi:10.2741/1950

Women with HNPCC: A target population for the chemoprevention of gynecologic cancers

Russell R. Broaddus, Karen H. Lu

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for colorectal cancer in HNPCC, the information regarding gynecological cancers in HNPCC remains limited. The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC.

Original language	English (US)
Pages (from-to)	2077-2080
Number of pages	4
Journal	Frontiers in Bioscience
Volume	11
Issue number	SUPPL. 1
DOIs	https://doi.org/10.2741/1950
State	Published - 2006

Keywords

Adenocarcinoma
Cancer
Endometrial Cancer
Endometrioid Carcinoma
Endometrium
Gynecologic Cancer
HNPCC
Neoplasia
Ovary
Review
Tumor

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.2741/1950

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title = "Women with HNPCC: A target population for the chemoprevention of gynecologic cancers",

abstract = "Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for colorectal cancer in HNPCC, the information regarding gynecological cancers in HNPCC remains limited. The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC.",

keywords = "Adenocarcinoma, Cancer, Endometrial Cancer, Endometrioid Carcinoma, Endometrium, Gynecologic Cancer, HNPCC, Neoplasia, Ovary, Review, Tumor",

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T2 - A target population for the chemoprevention of gynecologic cancers

AU - Broaddus, Russell R.

AU - Lu, Karen H.

PY - 2006

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N2 - Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for colorectal cancer in HNPCC, the information regarding gynecological cancers in HNPCC remains limited. The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC.

AB - Hereditary nonpolyposis colorectal cancer syndrome (HNPCC) is an autosomal-dominant inherited cancer susceptibility syndrome that is associated with increased risk of development of endometrial and ovarian cancers. Therefore, women with HNPCC are candidates for chemoprevention of gynecological cancers. Although there have been a number of clinical trials examining chemoprevention strategies for colorectal cancer in HNPCC, the information regarding gynecological cancers in HNPCC remains limited. The purpose of this review is to provide an analytical background about the current knowledge regarding gynecological cancers in patients with HNPCC.

KW - Adenocarcinoma

KW - Cancer

KW - Endometrial Cancer

KW - Endometrioid Carcinoma

KW - Endometrium

KW - Gynecologic Cancer

KW - HNPCC

KW - Neoplasia

KW - Ovary

KW - Review

KW - Tumor

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U2 - 10.2741/1950

DO - 10.2741/1950

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VL - 11

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JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

IS - SUPPL. 1

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Women with HNPCC: A target population for the chemoprevention of gynecologic cancers

Abstract

Keywords

ASJC Scopus subject areas

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