Workshop summary: Neotropical primates in biomedical research

This report summarizes presentations and discussions at an NIH-sponsored workshop on Neotropical Primates in Bio-medical Research, held in September 2010. Neotropical pri-mates (New World monkeys), with their smaller size, faster maturation, and shorter lifespans than Old World monkeys, are efficient models and present unique opportunities for studying human health and disease. After overviews of the most commonly used neotropical species-squirrel mon-keys, marmosets, and owl monkeys-speakers described the use of neotropical primates in specific areas of immunology, infectious disease, neuroscience, and physiology research. Presentations addressed the development of new research tools: immune-based reagents, fMRI technologies suited to these small primates, sequencing of the marmoset genome, the first germline transgenic monkey, and neotropical pri-mate induced pluripotent stem cells. In the discussions after the presentations, participants identified challenges to both continued use and development of new uses of neotropical primates in research and suggested the following actions to address the challenges: (1) mechanisms to support breeding colonies of some neotropical species to ensure a well-characterized domestic source; (2) resources for the continu-ing development of critical research tools to improve the immunological and hormonal characterization of neotropi-cal primates; (3) improved opportunities for networking among investigators who use neotropical primates, training and other measures to improve colony and veterinary man-agement, and continued research on neotropical primate management and veterinary care issues; (4) support for de-velopment activities to produce models that are more afford-able and more efficient for moving research "from benchside to bedside"; and (5) establishment of a small program that would fund "orphan" species.