TY - JOUR
T1 - Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia
AU - Schrezenmeier, Hubert
AU - Passweg, Jakob R.
AU - Marsh, Judith C.W.
AU - Bacigalupo, Andrea
AU - Bredeson, Christopher N.
AU - Bullorsky, Eduardo
AU - Camitta, Bruce M.
AU - Champlin, Richard E.
AU - Gale, Robert Peter
AU - Fuhrer, Monika
AU - Klein, John P.
AU - Locasciulli, Anna
AU - Oneto, Rosi
AU - Schattenberg, Antonius V.M.B.
AU - Socie, Gerard
AU - Eapen, Mary
PY - 2007/8/15
Y1 - 2007/8/15
N2 - We analyzed the outcome of 692 patients with severe aplastic anemia (SAA) receiving transplants from HLA-matched siblings. A total of 134 grafts were peripheral blood progenitor cell (PBPC) grafts, and 558 were bone marrow (BM) grafts. Rates of hematopoietic recovery and grades 2 to 4 chronic graft-versus-host disease (GVHD) were similar after PBPC and BM transplantations regardless of age at transplantation. In patients older than 20 years, chronic GVHD and overall mortality rates were similar after PBPC and BM transplantations. In patients younger than 20 years, rates of chronic GVHD (relative risk [RR] 2.82; P = .002) and overall mortality (RR 2.04; P = .024) were higher after transplantation of PBPCs than after transplantation of BM. In younger patients, the 5-year probabilities of overall survival were 73% and 85% after PBPC and BM transplantations, respectively. Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA.
AB - We analyzed the outcome of 692 patients with severe aplastic anemia (SAA) receiving transplants from HLA-matched siblings. A total of 134 grafts were peripheral blood progenitor cell (PBPC) grafts, and 558 were bone marrow (BM) grafts. Rates of hematopoietic recovery and grades 2 to 4 chronic graft-versus-host disease (GVHD) were similar after PBPC and BM transplantations regardless of age at transplantation. In patients older than 20 years, chronic GVHD and overall mortality rates were similar after PBPC and BM transplantations. In patients younger than 20 years, rates of chronic GVHD (relative risk [RR] 2.82; P = .002) and overall mortality (RR 2.04; P = .024) were higher after transplantation of PBPCs than after transplantation of BM. In younger patients, the 5-year probabilities of overall survival were 73% and 85% after PBPC and BM transplantations, respectively. Corresponding probabilities for older patients were 52% and 64%. These data indicate that BM grafts are preferred to PBPC grafts in young patients undergoing HLA-matched sibling donor transplantation for SAA.
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U2 - 10.1182/blood-2007-03-081596
DO - 10.1182/blood-2007-03-081596
M3 - Article
C2 - 17475907
AN - SCOPUS:34548050458
SN - 0006-4971
VL - 110
SP - 1397
EP - 1400
JO - Blood
JF - Blood
IS - 4
ER -