TY - JOUR
T1 - Worth a Pound of Cure? Emerging Strategies and Challenges in Cancer Immunoprevention
AU - Haldar, Saurav D.
AU - Vilar, Eduardo
AU - Maitra, Anirban
AU - Zaidi, Neeha
N1 - Publisher Copyright:
©2023 American Association for Cancer Research.
PY - 2023/9
Y1 - 2023/9
N2 - Cancer immunoprevention applies immunologic approaches such as vaccines to prevent, rather than to treat or cure, cancer. Despite limited success in the treatment of advanced disease, the development of cancer vaccines to intercept premalignant states is a promising area of current research. These efforts are supported by the rationale that vaccination in the premalignant setting is less susceptible to mechanisms of immune evasion compared with established cancer. Prophylactic vaccines have already been developed for a minority of cancers mediated by oncogenic viruses (e.g., hepatitis B and human papillomavirus). Extending the use of preventive vaccines to non-virally driven malignancies remains an unmet need to address the rising global burden of cancer. This review provides a broad overview of clinical trials in cancer immunoprevention with an emphasis on emerging vaccine targets and delivery platforms, translational challenges, and future directions.
AB - Cancer immunoprevention applies immunologic approaches such as vaccines to prevent, rather than to treat or cure, cancer. Despite limited success in the treatment of advanced disease, the development of cancer vaccines to intercept premalignant states is a promising area of current research. These efforts are supported by the rationale that vaccination in the premalignant setting is less susceptible to mechanisms of immune evasion compared with established cancer. Prophylactic vaccines have already been developed for a minority of cancers mediated by oncogenic viruses (e.g., hepatitis B and human papillomavirus). Extending the use of preventive vaccines to non-virally driven malignancies remains an unmet need to address the rising global burden of cancer. This review provides a broad overview of clinical trials in cancer immunoprevention with an emphasis on emerging vaccine targets and delivery platforms, translational challenges, and future directions.
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U2 - 10.1158/1940-6207.CAPR-22-0478
DO - 10.1158/1940-6207.CAPR-22-0478
M3 - Review article
C2 - 37001882
AN - SCOPUS:85167623145
SN - 1940-6207
VL - 16
SP - 483
EP - 495
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 9
ER -