X-ray fluorescence computed tomography with a Compton camera for a clinical application

Don Vernekohl; Moiz Ahmad; Garry Chinn; Lei Xing

doi:10.1109/NSSMIC.2016.8069550

X-ray fluorescence computed tomography with a Compton camera for a clinical application

Don Vernekohl, Moiz Ahmad, Garry Chinn, Lei Xing

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

XFCT is a promising new molecular imaging modality which is able to measure non-radioactive tracer molecules even in deep tissues. Unrestricted spatial resolution imaging with pencil beam x-ray excitation is possible but cannot be translated easily to clinical applications as scanning times are at least several hours. The spatial information accessed with Compton cameras (CCs) overcomes this drawback as fan or cone-beams can boost the measurement process. The spatial resolution and sensitivity performance of this new approach are studied on the basis of Monte-Carlo simulations. The results show that molecular sensitivities of 560 pM l^-1 are accessible at 30 mGy for the demonstrated lung scan scenario and FWHM below 6 mm for lesion diameters of 1 mm. The scanning time was reduced by a factor of 45 for the given example.

Original language	English (US)
Title of host publication	2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781509016426
DOIs	https://doi.org/10.1109/NSSMIC.2016.8069550
State	Published - Oct 16 2017
Externally published	Yes
Event	2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 - Strasbourg, France Duration: Oct 29 2016 → Nov 6 2016

Publication series

Name	2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
Volume	2017-January

Other

Other	2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
Country/Territory	France
City	Strasbourg
Period	10/29/16 → 11/6/16

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Instrumentation
Nuclear and High Energy Physics
Electronic, Optical and Magnetic Materials

Access to Document

10.1109/NSSMIC.2016.8069550

Cite this

Vernekohl, D., Ahmad, M., Chinn, G., & Xing, L. (2017). X-ray fluorescence computed tomography with a Compton camera for a clinical application. In 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 Article 8069550 (2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016; Vol. 2017-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2016.8069550

X-ray fluorescence computed tomography with a Compton camera for a clinical application. / Vernekohl, Don; Ahmad, Moiz; Chinn, Garry et al.
2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Institute of Electrical and Electronics Engineers Inc., 2017. 8069550 (2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016; Vol. 2017-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Vernekohl, D, Ahmad, M, Chinn, G & Xing, L 2017, X-ray fluorescence computed tomography with a Compton camera for a clinical application. in 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016., 8069550, 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016, vol. 2017-January, Institute of Electrical and Electronics Engineers Inc., 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016, Strasbourg, France, 10/29/16. https://doi.org/10.1109/NSSMIC.2016.8069550

Vernekohl D, Ahmad M, Chinn G, Xing L. X-ray fluorescence computed tomography with a Compton camera for a clinical application. In 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Institute of Electrical and Electronics Engineers Inc. 2017. 8069550. (2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016). doi: 10.1109/NSSMIC.2016.8069550

Vernekohl, Don ; Ahmad, Moiz ; Chinn, Garry et al. / X-ray fluorescence computed tomography with a Compton camera for a clinical application. 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016. Institute of Electrical and Electronics Engineers Inc., 2017. (2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016).

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abstract = "XFCT is a promising new molecular imaging modality which is able to measure non-radioactive tracer molecules even in deep tissues. Unrestricted spatial resolution imaging with pencil beam x-ray excitation is possible but cannot be translated easily to clinical applications as scanning times are at least several hours. The spatial information accessed with Compton cameras (CCs) overcomes this drawback as fan or cone-beams can boost the measurement process. The spatial resolution and sensitivity performance of this new approach are studied on the basis of Monte-Carlo simulations. The results show that molecular sensitivities of 560 pM l-1 are accessible at 30 mGy for the demonstrated lung scan scenario and FWHM below 6 mm for lesion diameters of 1 mm. The scanning time was reduced by a factor of 45 for the given example.",

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N2 - XFCT is a promising new molecular imaging modality which is able to measure non-radioactive tracer molecules even in deep tissues. Unrestricted spatial resolution imaging with pencil beam x-ray excitation is possible but cannot be translated easily to clinical applications as scanning times are at least several hours. The spatial information accessed with Compton cameras (CCs) overcomes this drawback as fan or cone-beams can boost the measurement process. The spatial resolution and sensitivity performance of this new approach are studied on the basis of Monte-Carlo simulations. The results show that molecular sensitivities of 560 pM l-1 are accessible at 30 mGy for the demonstrated lung scan scenario and FWHM below 6 mm for lesion diameters of 1 mm. The scanning time was reduced by a factor of 45 for the given example.

AB - XFCT is a promising new molecular imaging modality which is able to measure non-radioactive tracer molecules even in deep tissues. Unrestricted spatial resolution imaging with pencil beam x-ray excitation is possible but cannot be translated easily to clinical applications as scanning times are at least several hours. The spatial information accessed with Compton cameras (CCs) overcomes this drawback as fan or cone-beams can boost the measurement process. The spatial resolution and sensitivity performance of this new approach are studied on the basis of Monte-Carlo simulations. The results show that molecular sensitivities of 560 pM l-1 are accessible at 30 mGy for the demonstrated lung scan scenario and FWHM below 6 mm for lesion diameters of 1 mm. The scanning time was reduced by a factor of 45 for the given example.

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X-ray fluorescence computed tomography with a Compton camera for a clinical application

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