TY - JOUR
T1 - X region mutations of hepatitis B virus related to clinical severity
AU - Kim, Hong
AU - Lee, Seoung Ae
AU - Kim, Bum Joon
N1 - Funding Information:
Supported by National Research Foundation grant of Ministry of Science, ICT and Future Planning, South Korea, no. NRF- 2015R1C1A1A02037267; and Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, South Korea, no. HI14C0955.
Publisher Copyright:
© The Author(s) 2016.
PY - 2016/6/28
Y1 - 2016/6/28
N2 - Chronic hepatitis B virus (HBV) infection remains a major health problem, with more than 240 million people chronically infected worldwide and potentially 650000 deaths per year due to advanced liver diseases including liver cirrhosis and hepatocellular carcinoma (HCC). HBV-X protein (HBx) contributes to the biology and pathogenesis of HBV via stimulating virus replication or altering host gene expression related to HCC. The HBV X region contains only 465 bp encoding the 16.5 kDa HBx protein, which also contains several critical cis-elements such as enhancer, the core promoter and the microRNA-binding region. Thus, mutations in this region may affect not only the HBx open reading frame but also the overlapped ciselements. Recently, several types of HBx mutations significantly associated with clinical severity have been described, although the functional mechanism in most of these cases remains unsolved. This review article will mainly focus on the HBx mutations proven to be significantly related to clinical severity via epidemiological studies.
AB - Chronic hepatitis B virus (HBV) infection remains a major health problem, with more than 240 million people chronically infected worldwide and potentially 650000 deaths per year due to advanced liver diseases including liver cirrhosis and hepatocellular carcinoma (HCC). HBV-X protein (HBx) contributes to the biology and pathogenesis of HBV via stimulating virus replication or altering host gene expression related to HCC. The HBV X region contains only 465 bp encoding the 16.5 kDa HBx protein, which also contains several critical cis-elements such as enhancer, the core promoter and the microRNA-binding region. Thus, mutations in this region may affect not only the HBx open reading frame but also the overlapped ciselements. Recently, several types of HBx mutations significantly associated with clinical severity have been described, although the functional mechanism in most of these cases remains unsolved. This review article will mainly focus on the HBx mutations proven to be significantly related to clinical severity via epidemiological studies.
KW - Clinical severity
KW - Hepatitis B virus infection
KW - Hepatitis B virus-X protein mutation
KW - Hepatocellular carcinoma
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U2 - 10.3748/wjg.v22.i24.5467
DO - 10.3748/wjg.v22.i24.5467
M3 - Review article
C2 - 27350725
AN - SCOPUS:84978961914
SN - 1007-9327
VL - 22
SP - 5467
EP - 5478
JO - World journal of gastroenterology
JF - World journal of gastroenterology
IS - 24
ER -