Xeroderma pigmentosum variant cells are not defective in the repair of (6-4) photoproducts

David L. Mitchell; Carrie A. Haipek; Judith M. Clarkson

doi:10.1080/09553008714551661

Xeroderma pigmentosum variant cells are not defective in the repair of (6-4) photoproducts

David L. Mitchell, Carrie A. Haipek, Judith M. Clarkson

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Using radioimmunoassays specific for (6-4) photoproducts and cyclobutane dimers, Xeroderma pigmentosum variant cells appear to have a normal capacity for the repair of each of these lesions. However, these assays measure an early stage in the repair pathway and we do not exclude the possibility that repair is not successfully completed following UV irradiation and excision of DNA photoproducts.

Original language	English (US)
Pages (from-to)	201-205
Number of pages	5
Journal	International journal of radiation biology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1080/09553008714551661
State	Published - 1987

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1080/09553008714551661

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title = "Xeroderma pigmentosum variant cells are not defective in the repair of (6-4) photoproducts",

abstract = "Using radioimmunoassays specific for (6-4) photoproducts and cyclobutane dimers, Xeroderma pigmentosum variant cells appear to have a normal capacity for the repair of each of these lesions. However, these assays measure an early stage in the repair pathway and we do not exclude the possibility that repair is not successfully completed following UV irradiation and excision of DNA photoproducts.",

author = "Mitchell, {David L.} and Haipek, {Carrie A.} and Clarkson, {Judith M.}",

note = "Funding Information: Acknowledgments This work was supported by National Institute of Health grant CA",

year = "1987",

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T1 - Xeroderma pigmentosum variant cells are not defective in the repair of (6-4) photoproducts

AU - Mitchell, David L.

AU - Haipek, Carrie A.

AU - Clarkson, Judith M.

N1 - Funding Information: Acknowledgments This work was supported by National Institute of Health grant CA

PY - 1987

Y1 - 1987

N2 - Using radioimmunoassays specific for (6-4) photoproducts and cyclobutane dimers, Xeroderma pigmentosum variant cells appear to have a normal capacity for the repair of each of these lesions. However, these assays measure an early stage in the repair pathway and we do not exclude the possibility that repair is not successfully completed following UV irradiation and excision of DNA photoproducts.

AB - Using radioimmunoassays specific for (6-4) photoproducts and cyclobutane dimers, Xeroderma pigmentosum variant cells appear to have a normal capacity for the repair of each of these lesions. However, these assays measure an early stage in the repair pathway and we do not exclude the possibility that repair is not successfully completed following UV irradiation and excision of DNA photoproducts.

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Xeroderma pigmentosum variant cells are not defective in the repair of (6-4) photoproducts

Abstract

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