TY - JOUR
T1 - Zidovudine Improves Psoriasis in Human Immunodeficiency Virus—Positive Males
AU - Duvic, Madeleine
AU - Crane, Martin M.
AU - Conant, Marcus
AU - Mahoney, Stephen E.
AU - Reveille, John D.
AU - Lehrman, Sandra Nusinoff
PY - 1994/4
Y1 - 1994/4
N2 - Background and Design: Patients with human immunodeficiency virus (HIV) infection can develop severe psoriasis, which is difficult to treat using conventional therapy. Anecdotal case reports have suggested that administration of zidovudine can improve psoriasis in the HIV-infected patient. An open-label study was conducted to determine the safety and effectiveness of zidovudine therapy in 24 patients with HIV-associated psoriasis and to correlate response with laboratory and clinical variables. Results: Of 19 evaluable patients, 90% had either par- tial (58%) or complete (32%) improvement of their HIVassociated psoriasis during zidovudine therapy. Greater than 75% reduction in the body surface area involved was positively associated with antigenemia and an age younger than 30 years. Conclusions: Zidovudine therapy, at a dosage of 1200 mg/d, appears to be beneficial in the treatment of HIV-associated psoriasis, although long-term relapses occurred and the associated arthritis did not improve.
AB - Background and Design: Patients with human immunodeficiency virus (HIV) infection can develop severe psoriasis, which is difficult to treat using conventional therapy. Anecdotal case reports have suggested that administration of zidovudine can improve psoriasis in the HIV-infected patient. An open-label study was conducted to determine the safety and effectiveness of zidovudine therapy in 24 patients with HIV-associated psoriasis and to correlate response with laboratory and clinical variables. Results: Of 19 evaluable patients, 90% had either par- tial (58%) or complete (32%) improvement of their HIVassociated psoriasis during zidovudine therapy. Greater than 75% reduction in the body surface area involved was positively associated with antigenemia and an age younger than 30 years. Conclusions: Zidovudine therapy, at a dosage of 1200 mg/d, appears to be beneficial in the treatment of HIV-associated psoriasis, although long-term relapses occurred and the associated arthritis did not improve.
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U2 - 10.1001/archderm.1994.01690040051006
DO - 10.1001/archderm.1994.01690040051006
M3 - Article
C2 - 7909423
AN - SCOPUS:0028266554
SN - 0003-987X
VL - 130
SP - 447
EP - 451
JO - Archives of Dermatology
JF - Archives of Dermatology
IS - 4
ER -