Genomic Medicine

Search results

  • 2011

    SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression

    Ding, Z., Wu, C. J., Chu, G. C., Xiao, Y., Ho, D., Zhang, J., Perry, S. R., Labrot, E. S., Wu, X., Lis, R., Hoshida, Y., Hiller, D., Hu, B., Jiang, S., Zheng, H., Stegh, A. H., Scott, K. L., Signoretti, S., Bardeesy, N., Wang, Y. A., & 8 othersHill, D. E., Golub, T. R., Stampfer, M. J., Wong, W. H., Loda, M., Mucci, L., Chin, L. & Depinho, R. A., Feb 10 2011, In: Nature. 470, 7333, p. 269-276 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    417 Scopus citations

  • SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63

    Bornstein, C., Brosh, R., Molchadsky, A., Madar, S., Kogan-Sakin, I., Goldstein, I., Chakravarti, D., Flores, E. R., Goldfinger, N., Sarig, R. & Rotter, V., Apr 2011, In: Molecular and cellular biology. 31, 8, p. 1679-1689 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Telomere dysfunction induces metabolic and mitochondrial compromise

    Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., Maser, R. S., Tonon, G., Foerster, F., Xiong, R., Wang, Y. A., Shukla, S. A., Jaskelioff, M., Martin, E. S., Heffernan, T. P., Protopopov, A., & 10 othersIvanova, E., Mahoney, J. E., Kost-Alimova, M., Perry, S. R., Bronson, R., Liao, R., Mulligan, R., Shirihai, O. S., Chin, L. & DePinho, R. A., Feb 17 2011, In: Nature. 470, 7334, p. 359-365 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1009 Scopus citations

  • The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

    Gutierrez, A., Kentsis, A., Sanda, T., Holmfeldt, L., Chen, S. C., Zhang, J., Protopopov, A., Chin, L., Dahlberg, S. E., Neuberg, D. S., Silverman, L. B., Winter, S. S., Hunger, S. P., Sallan, S. E., Zha, S., Alt, F. W., Downing, J. R., Mullighan, C. G. & Look, A. T., Oct 13 2011, In: Blood. 118, 15, p. 4169-4173 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    150 Scopus citations

  • The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior

    Sánchez, N. S., Hill, C. R., Love, J. D., Soslow, J. H., Craig, E., Austin, A. F., Brown, C. B., Czirok, A., Camenisch, T. D. & Barnett, J. V., Oct 15 2011, In: Developmental Biology. 358, 2, p. 331-343 13 p.

    Research output: Contribution to journal › Article › peer-review

    29 Scopus citations

  • The genomic complexity of primary human prostate cancer

    Berger, M. F., Lawrence, M. S., Demichelis, F., Drier, Y., Cibulskis, K., Sivachenko, A. Y., Sboner, A., Esgueva, R., Pflueger, D., Sougnez, C., Onofrio, R., Carter, S. L., Park, K., Habegger, L., Ambrogio, L., Fennell, T., Parkin, M., Saksena, G., Voet, D., Ramos, A. H., & 21 othersPugh, T. J., Wilkinson, J., Fisher, S., Winckler, W., Mahan, S., Ardlie, K., Baldwin, J., Simons, J. W., Kitabayashi, N., MacDonald, T. Y., Kantoff, P. W., Chin, L., Gabriel, S. B., Gerstein, M. B., Golub, T. R., Meyerson, M., Tewari, A., Lander, E. S., Getz, G., Rubin, M. A. & Garraway, L. A., Feb 10 2011, In: Nature. 470, 7333, p. 214-220 7 p.

    Research output: Contribution to journal › Article › peer-review

    1011 Scopus citations

  • The prevention of biofilm colonization by multidrug-resistant pathogens that cause ventilator-associated pneumonia with antimicrobial-coated endotracheal tubes

    Raad, I. I., Mohamed, J. A., Reitzel, R. A., Jiang, Y., Dvorak, T. L., Ghannoum, M. A., Hachem, R. Y. & Chaftari, A. M., Apr 2011, In: Biomaterials. 32, 11, p. 2689-2694 6 p.

    Research output: Contribution to journal › Article › peer-review

    49 Scopus citations

  • Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

    Pedroza-Gonzalez, A., Xu, K., Wu, T. C., Aspord, C., Tindle, S., Marches, F., Gallegos, M., Burton, E. C., Savino, D., Hori, T., Tanaka, Y., Zurawski, S., Zurawski, G., Bover, L., Liu, Y. J., Banchereau, J. & Palucka, A. K., Mar 14 2011, In: Journal of Experimental Medicine. 208, 3, p. 479-490 12 p.

    Research output: Contribution to journal › Article › peer-review

    193 Scopus citations

  • TIN2 protein dyskeratosis congenita missense mutants are defective in association with telomerase

    Yang, D., He, Q., Kim, H., Ma, W. & Songyang, Z., Jul 1 2011, In: Journal of Biological Chemistry. 286, 26, p. 23022-23030 9 p.

    Research output: Contribution to journal › Article › peer-review

    52 Scopus citations

  • Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma

    Peng, Z., Pal, A., Han, D., Wang, S., Maxwell, D., Levitzki, A., Talpaz, M., Donato, N. J. & Bornmann, W., Dec 1 2011, In: Bioorganic and Medicinal Chemistry. 19, 23, p. 7194-7204 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    7 Scopus citations

  • Whole recombinant yeast vaccine induces antitumor immunity and improves survival in a genetically engineered mouse model of melanoma

    Tanaka, A., Jensen, J. D., Prado, R., Riemann, H., Shellman, Y. G., Norris, D. A., Chin, L., Yee, C. & Fujita, M., Aug 2011, In: Gene Therapy. 18, 8, p. 827-834 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • Zebrafish as a model system to study the physiological function of telomeric protein TPP1

    Xie, Y., Yang, D., He, Q. & Songyang, Z., 2011, In: PloS one. 6, 2, e16440.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations
  • 2012

    AACR Cancer Progress Report 2012.

    Cantley, L. C., Dalton, W. S., DuBois, R. N., Finn, O. J., Futreal, P. A., Golub, T. R., Hait, W. N., Lozano, G., Maris, J. M., Nelson, W. G., Sawyers, C. L., Schreiber, S. L., Spitz, M. R. & Steeg, P. S., Nov 1 2012, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 18, 21 Suppl, p. S1-100

    Research output: Contribution to journal › Article › peer-review

    19 Scopus citations

  • A case of advanced gastrointestinal stromal tumor successfully resected after neoadjuvant chemotherapy with imatinib mesylate

    Inoue, A., Koshiishi, N., Kinuta, S., Maruyama, S. & Tsujiyama, A., 2012, In: Japanese Journal of Gastroenterological Surgery. 45, 9, p. 944-951 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A landscape of driver mutations in melanoma

    Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J. P., Nickerson, E., Auclair, D., Li, L., Place, C., Dicara, D., Ramos, A. H., Lawrence, M. S., Cibulskis, K., Sivachenko, A., Voet, D., Saksena, G., Stransky, N., Onofrio, R. C., Winckler, W., & 20 othersArdlie, K., Wagle, N., Wargo, J., Chong, K., Morton, D. L., Stemke-Hale, K., Chen, G., Noble, M., Meyerson, M., Ladbury, J. E., Davies, M. A., Gershenwald, J. E., Wagner, S. N., Hoon, D. S. B., Schadendorf, D., Lander, E. S., Gabriel, S. B., Getz, G., Garraway, L. A. & Chin, L., Jul 20 2012, In: Cell. 150, 2, p. 251-263 13 p.

    Research output: Contribution to journal › Article › peer-review

    2003 Scopus citations

  • Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties

    Bragado, P., Estrada, Y., Sosa, M. S., Avivar-Valderas, A., Cannan, D., Genden, E., Teng, M., Ranganathan, A. C., Wen, H. C., Kapoor, A., Bernstein, E. & Aguirre-Ghiso, J. A., Jan 20 2012, In: PloS one. 7, 1, e29974.

    Research output: Contribution to journal › Article › peer-review

    25 Scopus citations

  • Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer

    Hu, J., Hwang, S. S., Liesa, M., Gan, B., Sahin, E., Jaskelioff, M., Ding, Z., Ying, H., Boutin, A. T., Zhang, H., Johnson, S., Ivanova, E., Kost-Alimova, M., Protopopov, A., Wang, Y. A., Shirihai, O. S., Chin, L. & Depinho, R. A., Feb 17 2012, In: Cell. 148, 4, p. 651-663 13 p.

    Research output: Contribution to journal › Article › peer-review

    221 Scopus citations

  • AS601245, an anti-inflammatory JNK inhibitor, and clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells

    Cerbone, A., Toaldo, C., Pizzimenti, S., Pettazzoni, P., Dianzani, C., Minelli, R., Ciamporcero, E., Roma, G., Dianzani, M. U., Canaparo, R., Ferretti, C. & Barrera, G., 2012, In: PPAR Research. 269751.

    Research output: Contribution to journal › Article › peer-review

    24 Scopus citations

  • Association between HLA-DQB1 gene and patients with acute lymphoblastic leukemia (ALL)

    Orouji, E., Afshari, J. T., Badiee, Z., Shirdel, A. & Alipour, A., May 2012, In: International journal of hematology. 95, 5, p. 551-555 5 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion

    Hill, C. R., Sanchez, N. S., Love, J. D., Arrieta, J. A., Hong, C. C., Brown, C. B., Austin, A. F. & Barnett, J. V., May 2012, In: Cellular Signalling. 24, 5, p. 1012-1022 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    34 Scopus citations

  • CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl

    Bao, M., Hanabuchi, S., Facchinetti, V., Du, Q., Bover, L., Plumas, J., Chaperot, L., Cao, W., Qin, J., Sun, S. C. & Liu, Y. J., Jul 15 2012, In: Journal of Immunology. 189, 2, p. 786-792 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells

    Minelli, R., Serpe, L., Pettazzoni, P., Minero, V., Barrera, G., Gigliotti, C. L., Mesturini, R., Rosa, A. C., Gasco, P., Vivenza, N., Muntoni, E., Fantozzi, R., Dianzani, U., Zara, G. P. & Dianzani, C., May 2012, In: British Journal of Pharmacology. 166, 2, p. 587-601 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    47 Scopus citations

  • Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels

    Lustgarten, M. S., Bhattacharya, A., Muller, F. L., Jang, Y. C., Shimizu, T., Shirasawa, T., Richardson, A. & Van Remmen, H., Jun 8 2012, In: Biochemical and biophysical research communications. 422, 3, p. 515-521 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    67 Scopus citations

  • Comprehensive genomic characterization of squamous cell lung cancers

    Hammerman, P. S., Voet, D., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Getz, G., Imielinski, M., Helman, E., Hernandez, B., Pho, N. H., Meyerson, M., Chu, A., Hye-Chun, J. E., Mungall, A. J., & 316 othersPleasance, E., Robertson, A. G., Sipahimalani, P., Stoll, D., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chuah, E., Coope, R. J. N., Corbett, R., Dhalla, N., Guin, R., He, A., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, K., Nip, K. M., Olshen, A., Schein, J. E., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R., Zeng, T., Zhao, Y., Jones, S. J. M., Marra, M. A., Saksena, G., Cherniack, A. D., Schumacher, S. E., Tabak, B., Carter, S. L., Nguyen, H., Onofrio, R. C., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Protopopov, A., Zhang, J., Hadjipanayis, A., Lee, S., Xi, R., Yang, L., Ren, X., Zhang, H., Shukla, S., Chen, P. C., Haseley, P., Lee, E., Chin, L., Park, P. J., Kucherlapati, R., Socci, N. D., Liang, Y., Schultz, N., Borsu, L., Lash, A. E., Viale, A., Sander, C., Ladanyi, M., Auman, J. T., Hoadley, K. A., Wilkerson, M. D., Shi, Y., Liquori, C., Meng, S., Li, L., Turman, Y. J., Topal, M. D., Tan, D., Waring, S., Buda, E., Walsh, J., Jones, C. D., Mieczkowski, P. A., Singh, D., Wu, J., Gulabani, A., Dolina, P., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Stuart, J., Mose, L. E., Jefferys, S. R., Balu, S., O'Connor, B. D., Chiang, D., Liu, J., Chiang, D. Y., Hayes, D. N., Perou, C. M., Cope, L., Weisenberger, D., Danilova, L., Weisenberger, D. J., Maglinte, D. T., Pan, F., Van Den Berg, D. J., Triche, T., Herman, J. G., Baylin, S. B., Laird, P. W., Noble, M., Gehlenborg, N., DiCara, D., Zhang, J., Wu, C. J., Liu, S. Y., Zou, L., Lin, P., Cho, J., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Sinha, R., Ciriello, G., Cerami, E., Gross, B., Jacobsen, A., Gao, J., Aksoy, B. A., Weinhold, N., Ramirez, R., Taylor, B. S., Antipin, Y., Reva, B., Mo, Q., Seshan, V., Paik, P. K., Akbani, R., Zhang, N., Broom, B. M., Casasent, T., Unruh, A., Wakefield, C., Cason, R. C., Baggerly, K. A., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Ng, S., Goldstein, T., Waltman, P., Sokolov, A., Collisson, E., Ellrott, K., Collisson, E. A., Zerbino, D., Ma, S., Craft, B., Du, Y., Cabanski, C., Walter, V., Marron, J. S., Liu, Y., Wang, K., Prins, J. F., Creighton, C. J., Zhang, Y., Travis, W. D., Rekhtman, N., Yi, J., Aubry, M. C., Cheney, R., Dacic, S., Flieder, D., Funkhouser, W., Illei, P., Myers, J., Tsao, M. S., Penny, R., Mallery, D., Shelton, T., Hatfield, M., Morris, S., Yena, P., Shelton, C., Sherman, M., Paulauskis, J., Govindan, R., Azodo, I., Beer, D., Bose, R., Byers, L. A., Carbone, D., Chang, L. W., Chun, E., Ding, L., Heymach, J., Ida, C., Johnson, B., Jurisica, I., Kaufman, J., Kosari, F., Kwiatkowski, D., Maher, C. A., Pao, W., Peifer, M., Robertson, G., Rusch, V., Siegfried, J., Sougnez, C., Thomas, R. K., Tomaszek, S., Vaske, C., Wheeler, D., Wigle, D. A., Wilks, C., Zhang, J. J., Jensen, M. A., Sfeir, R., Kahn, A. B., Chu, A. L., Kothiyal, P., Wang, Z., Snyder, E. E., Pontius, J., Pihl, T. D., Backus, M., Walton, J., Baboud, J., Berton, D. L., Nicholls, M. C., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P. A., Alonso, S., Sanbhadti, R. N., Barletta, S. P., Greene, J. M., Pot, D. A., Bandarchi-Chamkhaleh, B., Boyd, J., Weaver, J., Azodo, I. A., Tomaszek, S. C., Yang, P., Brock, M. V., Rogers, K., Rutledge, M., Brown, T., Lee, B., Shin, J., Trusty, D., Dhir, R., Siegfried, J. M., Potapova, O., Fedosenko, K. V., Zakowski, M., Nemirovich-Danchenko, E., Iacocca, M. V., Brown, J., Rabeno, B., Czerwinski, C., Petrelli, N., Fan, Z., Todaro, N., Eckman, J., Rathmell, W. K., Thorne, L. B., Huang, M., Boice, L., Hill, A., Curley, E., Morrison, C., Gaudioso, C., Bartlett, J. M. S., Kodeeswaran, S., Zanke, B., Sekhon, H., David, K., Juhl, H., Le, X. V., Kohl, B., Thorp, R., Tien, N. V., Bang, N. V., Sussman, H., Phu, B. D., Hajek, R., Hung, N. P., Khan, K. Z., Muley, T., Mills Shaw, K. R., Sheth, M., Yang, L., Demchok, J. A., Davidsen, T., Buetow, K., Eley, G., Ferguson, M., Dillon, L. A. L., Schaefer, C., Guyer, M. S., Ozenberger, B. A., Palchik, J. D., Peterson, J., Sofia, H. J., Thomson, E., Johnson, B. E. & Shen, R., Sep 27 2012, In: Nature. 489, 7417, p. 519-525 7 p.

    Research output: Contribution to journal › Article › peer-review

    3127 Scopus citations

  • Comprehensive molecular characterization of human colon and rectal cancer

    Muzny, D. M., Bainbridge, M. N., Chang, K., Dinh, H. H., Drummond, J. A., Fowler, G., Kovar, C. L., Lewis, L. R., Morgan, M. B., Newsham, I. F., Reid, J. G., Santibanez, J., Shinbrot, E., Trevino, L. R., Wu, Y. Q., Wang, M., Gunaratne, P., Donehower, L. A., Creighton, C. J., Wheeler, D. A., & 293 othersGibbs, R. A., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Ding, L., Fulton, R. S., Koboldt, D. C., Wylie, T., Walker, J., Dooling, D. J., Fulton, L., Delehaunty, K. D., Fronick, C. C., Demeter, R., Mardis, E. R., Wilson, R. K., Chu, A., Chun, H. J. E., Mungall, A. J., Pleasance, E., Gordon Robertson, A., Stoll, D., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chuah, E., Coope, R. J. N., Dhalla, N., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Schein, J. E., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R., Zeng, T., Zhao, Y., Jones, S. J. M., Marra, M. A., Bass, A. J., Ramos, A. H., Saksena, G., Cherniack, A. D., Schumacher, S. E., Tabak, B., Carter, S. L., Pho, N. H., Nguyen, H., Onofrio, R. C., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Meyerson, M., Protopopov, A., Hadjipanayis, A., Lee, E., Xi, R., Yang, L., Ren, X., Sathiamoorthy, N., Chen, P. C., Haseley, P., Xiao, Y., Lee, S., Seidman, J., Chin, L., Park, P. J., Kucherlapati, R., Todd Auman, J., Hoadley, K. A., Du, Y., Wilkerson, M. D., Shi, Y., Liquori, C., Meng, S., Li, L., Turman, Y. J., Topal, M. D., Tan, D., Waring, S., Buda, E., Walsh, J., Jones, C. D., Mieczkowski, P. A., Singh, D., Wu, J., Gulabani, A., Dolina, P., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M., Mose, L. E., Jefferys, S. R., Balu, S., O'Connor, B. D., Prins, J. F., Chiang, D. Y., Neil Hayes, D., Perou, C. M., Hinoue, T., Weisenberger, D. J., Maglinte, D. T., Pan, F., Berman, B. P., Van Den Berg, D. J., Shen, H., Triche, T., Baylin, S. B., Laird, P. W., Getz, G., Noble, M., Voat, D., Gehlenborg, N., Dicara, D., Zhang, J., Zhang, H., Wu, C. J., Liu, S. Y., Shukla, S., Zhou, L., Lin, P., Park, R. W., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Thorsson, V., Reynolds, S. M., Bernard, B., Kreisberg, R., Lin, J., Iype, L., Bressler, R., Erkkilä, T., Gundapuneni, M., Liu, Y., Norberg, A., Robinson, T., Yang, D., Zhang, W., Shmulevich, I., De Ronde, J. J., Schultz, N., Cerami, E., Ciriello, G., Goldberg, A. P., Gross, B., Jacobsen, A., Gao, J., Kaczkowski, B., Sinha, R., Arman Aksoy, B., Antipin, Y., Reva, B., Shen, R., Taylor, B. S., Ladanyi, M., Sander, C., Akbani, R., Zhang, N., Broom, B. M., Casasent, T., Unruh, A., Wakefield, C., Hamilton, S. R., Craig Cason, R., Baggerly, K. A., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Zachary Sanborn, J., Vaske, C. J., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Ng, S., Goldstein, T., Ellrott, K., Collisson, E., Cozen, A. E., Zerbino, D., Wilks, C., Craft, B., Spellman, P., Penny, R., Shelton, T., Hatfield, M., Morris, S., Yena, P., Shelton, C., Sherman, M., Paulauskis, J., Gastier-Foster, J. M., Bowen, J., Ramirez, N. C., Black, A., Pyatt, R., Wise, L., White, P., Bertagnolli, M., Brown, J., Chan, T. A., Chu, G. C., Czerwinski, C., Denstman, F., Dhir, R., Dörner, A., Fuchs, C. S., Guillem, J. G., Iacocca, M., Juhl, H., Kaufman, A., Iii, B. K., Van Le, X., Mariano, M. C., Medina, E. N., Meyers, M., Nash, G. M., Paty, P. B., Petrelli, N., Rabeno, B., Richards, W. G., Solit, D., Swanson, P., Temple, L., Tepper, J. E., Thorp, R., Vakiani, E., Weiser, M. R., Willis, J. E., Witkin, G., Zeng, Z., Zinner, M. J., Zornig, C., Jensen, M. A., Sfeir, R., Kahn, A. B., Chu, A. L., Kothiyal, P., Wang, Z., Snyder, E. E., Pontius, J., Pihl, T. D., Ayala, B., Backus, M., Walton, J., Whitmore, J., Baboud, J., Berton, D. L., Nicholls, M. C., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P. A., Alonso, S., Sanbhadti, R. N., Barletta, S. P., Greene, J. M., Pot, D. A., Shaw, K. R. M., Dillon, L. A. L., Buetow, K., Davidsen, T., Demchok, J. A., Eley, G., Ferguson, M., Fielding, P., Schaefer, C., Sheth, M., Yang, L., Guyer, M. S., Ozenberger, B. A., Palchik, J. D., Peterson, J., Sofia, H. J. & Thomson., E., Jul 19 2012, In: Nature. 487, 7407, p. 330-337 8 p.

    Research output: Contribution to journal › Article › peer-review

    6383 Scopus citations

  • Comprehensive molecular portraits of human breast tumours

    Koboldt, D. C., Fulton, R. S., McLellan, M. D., Schmidt, H., Kalicki-Veizer, J., McMichael, J. F., Fulton, L. L., Dooling, D. J., Ding, L., Mardis, E. R., Wilson, R. K., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Carter, C., Chu, A., Chuah, E., Chun, H. J. E., Coope, R. J. N., & 323 othersDhalla, N., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Pleasance, E., Robertson, A. G., Schein, J. E., Shafiei, A., Sipahimalani, P., Slobodan, J. R., Stoll, D., Tam, A., Thiessen, N., Varhol, R. J., Wye, N., Zeng, T., Zhao, Y., Birol, I., Jones, S. J. M., Marra, M. A., Cherniack, A. D., Saksena, G., Onofrio, R. C., Pho, N. H., Carter, S. L., Schumacher, S. E., Tabak, B., Hernandez, B., Gentry, J., Nguyen, H., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Getz, G., Gabriel, S. B., Meyerson, M., Chin, L., Kucherlapati, R., Hoadley, K. A., Auman, J. T., Fan, C., Turman, Y. J., Shi, Y., Li, L., Topal, M. D., He, X., Chao, H. H., Prat, A., Silva, G. O., Iglesia, M. D., Zhao, W., Usary, J., Berg, J. S., Adams, M., Booker, J., Wu, J., Gulabani, A., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Mose, L. E., Jefferys, S. R., Balu, S., Parker, J. S., Hayes, D. N., Perou, C. M., Malik, S., Mahurkar, S., Shen, H., Weisenberger, D. J., Triche, T., Lai, P. H., Bootwalla, M. S., Maglinte, D. T., Berman, B. P., Van Den Berg, D. J., Baylin, S. B., Laird, P. W., Creighton, C. J., Donehower, L. A., Noble, M., Voet, D., Gehlenborg, N., Di Cara, D., Zhang, J., Zhang, H., Wu, C. J., Yingchun Liu, S., Lawrence, M. S., Zou, L., Sivachenko, A., Lin, P., Stojanov, P., Jing, R., Cho, J., Sinha, R., Park, R. W., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Park, P. J., Reynolds, S., Kreisberg, R. B., Bernard, B., Bressler, R., Erkkila, T., Lin, J., Thorsson, V., Zhang, W., Shmulevich, I., Ciriello, G., Weinhold, N., Schultz, N., Gao, J., Cerami, E., Gross, B., Jacobsen, A., Sinha, R., Aksoy, B. A., Antipin, Y., Reva, B., Shen, R., Taylor, B. S., Ladanyi, M., Sander, C., Anur, P., Spellman, P. T., Lu, Y., Liu, W., Verhaak, R. R. G., Mills, G. B., Akbani, R., Zhang, N., Broom, B. M., Casasent, T. D., Wakefield, C., Unruh, A. K., Baggerly, K., Coombes, K., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Zhu, J., Szeto, C. C., Scott, G. K., Yau, C., Paull, E. O., Carlin, D., Wong, C., Sokolov, A., Thusberg, J., Mooney, S., Ng, S., Goldstein, T. C., Ellrott, K., Grifford, M., Wilks, C., Ma, S., Craft, B., Yan, C., Hu, Y., Meerzaman, D., Gastier-Foster, J. M., Bowen, J., Ramirez, N. C., Black, A. D., Pyatt, R. E., White, P., Zmuda, E. J., Frick, J., Lichtenberg, T. M., Brookens, R., George, M. M., Gerken, M. A., Harper, H. A., Leraas, K. M., Wise, L. J., Tabler, T. R., McAllister, C., Barr, T., Hart-Kothari, M., Tarvin, K., Saller, C., Sandusky, G., Mitchell, C., Iacocca, M. V., Brown, J., Rabeno, B., Czerwinski, C., Petrelli, N., Dolzhansky, O., Abramov, M., Voronina, O., Potapova, O., Marks, J. R., Suchorska, W. M., Murawa, D., Kycler, W., Ibbs, M., Korski, K., Spychała, A., Murawa, P., Brzeziński, J. J., Perz, H., Łaźniak, R., Teresiak, M., Tatka, H., Leporowska, E., Bogusz-Czerniewicz, M., Malicki, J., Mackiewicz, A., Wiznerowicz, M., Van Le, X., Kohl, B., Viet Tien, N., Thorp, R., Van Bang, N., Sussman, H., Phu, B. D., Hajek, R., Hung, N. P., Phuong, T. V. T., Thang, H. Q., Khan, K. Z., Penny, R., Mallery, D., Curley, E., Shelton, C., Yena, P., Ingle, J. N., Couch, F. J., Lingle, W. L., King, T. A., Gonzalez-Angulo, A. M., Dyer, M. D., Liu, S., Meng, X., Patangan, M., Waldman, F., Stöppler, H., Rathmell, W. K., Thorne, L., Huang, M., Boice, L., Hill, A., Morrison, C., Gaudioso, C., Bshara, W., Daily, K., Egea, S. C., Pegram, M. D., Gomez-Fernandez, C., Dhir, R., Bhargava, R., Brufsky, A., Shriver, C. D., Hooke, J. A., Campbell, J. L., Mural, R. J., Hu, H., Somiari, S., Larson, C., Deyarmin, B., Kvecher, L., Kovatich, A. J., Ellis, M. J., Stricker, T., White, K., Olopade, O., Luo, C., Chen, Y., Bose, R., Chang, L. W., Beck, A. H., Pihl, T., Jensen, M., Sfeir, R., Kahn, A., Chu, A., Kothiyal, P., Wang, Z., Snyder, E., Pontius, J., Ayala, B., Backus, M., Walton, J., Baboud, J., Berton, D., Nicholls, M., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P., Alonso, S., Sanbhadti, R., Barletta, S., Pot, D., Sheth, M., Demchok, J. A., Shaw, K. R. M., Yang, L., Eley, G., Ferguson, M. L., Tarnuzzer, R. W., Zhang, J., Dillon, L. A. L., Buetow, K., Fielding, P., Ozenberger, B. A., Guyer, M. S., Sofia, H. J. & Palchik, J. D., Oct 4 2012, In: Nature. 490, 7418, p. 61-70 10 p.

    Research output: Contribution to journal › Article › peer-review

    8965 Scopus citations

  • Crystal structure of a major seed storage protein, 11S proglobulin, from Amaranthus hypochondriacus: Insight into its physico-chemical properties

    Tandang-Silvas, M. R., Cabanos, C. S., Carrazco Peña, L. D., De La Rosa, A. P. B., Osuna-Castro, J. A., Utsumi, S., Mikami, B. & Maruyama, N., Nov 15 2012, In: Food Chemistry. 135, 2, p. 819-826 8 p.

    Research output: Contribution to journal › Article › peer-review

    32 Scopus citations

  • Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

    Jang, Y. C., Liu, Y., Hayworth, C. R., Bhattacharya, A., Lustgarten, M. S., Muller, F. L., Chaudhuri, A., Qi, W., Li, Y., Huang, J. Y., Verdin, E., Richardson, A. & Van Remmen, H., Oct 2012, In: Aging Cell. 11, 5, p. 770-782 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    75 Scopus citations

  • Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

    Bhattacharya, A., Bokov, A., Muller, F. L., Jernigan, A. L., Maslin, K., Diaz, V., Richardson, A. & Van Remmen, H., Aug 2012, In: Neurobiology of Aging. 33, 8, p. 1829-1832 4 p.

    Research output: Contribution to journal › Article › peer-review

    51 Scopus citations

  • DNA breaks and chromosome pulverization from errors in mitosis

    Crasta, K., Ganem, N. J., Dagher, R., Lantermann, A. B., Ivanova, E. V., Pan, Y., Nezi, L., Protopopov, A., Chowdhury, D. & Pellman, D., Feb 2 2012, In: Nature. 482, 7383, p. 53-58 6 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    907 Scopus citations

  • Emerging insights into the molecular and cellular basis of glioblastoma

    Dunn, G. P., Rinne, M. L., Wykosky, J., Genovese, G., Quayle, S. N., Dunn, I. F., Agarwalla, P. K., Chheda, M. G., Campos, B., Wang, A., Brennan, C., Ligon, K. L., Furnari, F., Cavene, W. K., Depinho, R. A., Chin, L. & Hah, W. C., 2012, In: Genes and Development. 26, 8, p. 756-784 29 p.

    Research output: Contribution to journal › Article › peer-review

    445 Scopus citations

  • Erratum: Identification and characterization of two novel JARID1C mutations: Suggestion of an emerging genotype-phenotype correlation (European Journal of Human Genetics (2010) 18 (330-335) DOI: 10.1038/ejhg.2009.175)

    Rujirabanjerd, S., Nelson, J., Tarpey, P. S., Hackett, A., Edkins, S., Raymond, F. L., Schwartz, C. E., Turner, G., Iwase, S., Shi, Y., Futreal, P. A., Stratton, M. R. & Gecz, J., Sep 2012, In: European Journal of Human Genetics. 20, 9, p. 1010 1 p.

    Research output: Contribution to journal › Comment/debate › peer-review

  • Erratum: Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo (Journal of Immunology (2009) 183 (7842-7850))

    Han, L., Wang, W., Fang, Y., Feng, Z., Liao, S., Li, W., Li, Y., Li, C., Maitituoheti, M., Dong, H., Lai, Z., Gao, Q., Xi, L., Wu, M., Wang, D., Zhou, J., Meng, L., Wang, S. & Ma, D., May 1 2012, In: Journal of Immunology. 188, 9, p. 4709 1 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access

  • Erratum: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (Nature Medicine (2012) 18 (1503-1510))

    Kwong, L. N., Costello, J. C., Liu, H., Jiang, S., Helms, T. L., Langsdorf, A. E., Jakubosky, D., Genovese, G., Muller, F., Jeong, J. H., Bender, R. P., Chu, G. C., Flaherty, K. T., Wargo, J. A., Collins, J. J. & Chin, L., Dec 2012, In: Nature medicine. 18, 12, p. 1857 1 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    2 Scopus citations

  • Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells

    Kumar, A., Xu, J., Sung, B., Kumar, S., Yu, D., Aggarwal, B. B. & Mehta, K., Jan 6 2012, In: Breast Cancer Research. 14, 1, R4.

    Research output: Contribution to journal › Article › peer-review

    51 Scopus citations

  • H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

    Chicas, A., Kapoor, A., Wang, X., Aksoy, O., Evertts, A. G., Zhang, M. Q., Garcia, B. A., Bernstein, E. & Lowe, S. W., Jun 5 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 8971-8976 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    125 Scopus citations

  • Heavy-ion beam irradiation is an effective technique for reducing major allergens in peanut seeds

    Cabanos, C. S., Katayama, H., Urabe, H., Kuwata, C., Murota, Y., Abe, T., Okumoto, Y. & Maruyama, N., Aug 2012, In: Molecular Breeding. 30, 2, p. 1037-1044 8 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Improved antibiotic-impregnated catheters with extended-spectrum activity against resistant bacteria and fungi

    Raad, I., Mohamed, J. A., Reitzel, R. A., Jiang, Y., Raad, S., Al Shuaibi, M., Chaftari, A. M. & Hachem, R. Y., Feb 2012, In: Antimicrobial agents and chemotherapy. 56, 2, p. 935-941 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    66 Scopus citations

  • Integrative functional genomics identifies RINT1 as a novel GBM oncogene

    Quayle, S. N., Chheda, M. G., Shukla, S. A., Wiedemeyer, R., Tamayo, P., Dewan, R. W., Zhuang, L., Huang-Hobbs, E., Haidar, S., Xiao, Y., Ligon, K. L., Hahn, W. C. & Chin, L., Nov 2012, In: Neuro-oncology. 14, 11, p. 1325-1331 7 p.

    Research output: Contribution to journal › Article › peer-review

    13 Scopus citations

  • Intratumor heterogeneity: Seeing the wood for the trees

    Yap, T. A., Gerlinger, M., Futreal, P. A., Pusztai, L. & Swanton, C., Mar 28 2012, In: Science translational medicine. 4, 127, 127ps10.

    Research output: Contribution to journal › Review article › peer-review

    422 Scopus citations

  • K63-linked ubiquitination in kinase activation and cancer

    Wang, G., Gao, Y., Li, L., Jin, G., Cai, Z., Chao, J. I. & Lin, H. K., 2012, In: Frontiers in Oncology. 2, JAN, 00005.

    Research output: Contribution to journal › Review article › peer-review

    82 Scopus citations

  • Melanoma: From mutations to medicine

    Tsao, H., Chin, L., Garraway, L. A. & Fisher, D. E., Jun 1 2012, In: Genes and Development. 26, 11, p. 1131-1155 25 p.

    Research output: Contribution to journal › Review article › peer-review

    399 Scopus citations

  • Melanoma genome sequencing reveals frequent PREX2 mutations

    Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., Zhang, H., Zeid, R., Ren, X., Cibulskis, K., Sivachenko, A. Y., Wagle, N., Sucker, A., Sougnez, C., Onofrio, R., Ambrogio, L., & 28 othersAuclair, D., Fennell, T., Carter, S. L., Drier, Y., Stojanov, P., Singer, M. A., Voet, D., Jing, R., Saksena, G., Barretina, J., Ramos, A. H., Pugh, T. J., Stransky, N., Parkin, M., Winckler, W., Mahan, S., Ardlie, K., Baldwin, J., Wargo, J., Schadendorf, D., Meyerson, M., Gabriel, S. B., Golub, T. R., Wagner, S. N., Lander, E. S., Getz, G., Chin, L. & Garraway, L. A., May 24 2012, In: Nature. 485, 7399, p. 502-506 5 p.

    Research output: Contribution to journal › Article › peer-review

    588 Scopus citations

  • microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma

    Genovese, G., Ergun, A., Shukla, S. A., Campos, B., Hanna, J., Ghosh, P., Quayle, S. N., Rai, K., Colla, S., Ying, H., Wu, C. J., Sarkar, S., Xiao, Y., Zhang, J., Zhang, H., Kwong, L., Dunn, K., Wiedemeyer, W. R., Brennan, C., Zheng, H., & 3 othersRimm, D. L., Collins, J. J. & Chin, L., Aug 2012, In: Cancer discovery. 2, 8, p. 736-749 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    96 Scopus citations

  • Mitochondrial 'flashes': A radical concept repHined

    Schwarzländer, M., Murphy, M. P., Duchen, M. R., Logan, D. C., Fricker, M. D., Halestrap, A. P., Müller, F. L., Rizzuto, R., Dick, T. P., Meyer, A. J. & Sweetlove, L. J., Oct 2012, In: Trends in Cell Biology. 22, 10, p. 503-508 6 p.

    Research output: Contribution to journal › Review article › peer-review

    73 Scopus citations

  • Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells

    Minelli, R., Cavalli, R., Ellis, L., Pettazzoni, P., Trotta, F., Ciamporcero, E., Barrera, G., Fantozzi, R., Dianzani, C. & Pili, R., Nov 20 2012, In: European Journal of Pharmaceutical Sciences. 47, 4, p. 686-694 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    70 Scopus citations

  • Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

    Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., Yan, H., Wang, W., Chen, S., Viale, A., Zheng, H., Paik, J. H., Lim, C., Guimaraes, A. R., Martin, E. S., Chang, J., & 11 othersHezel, A. F., Perry, S. R., Hu, J., Gan, B., Xiao, Y., Asara, J. M., Weissleder, R., Wang, Y. A., Chin, L., Cantley, L. C. & Depinho, R. A., Apr 27 2012, In: Cell. 149, 3, p. 656-670 15 p.

    Research output: Contribution to journal › Article › peer-review

    1458 Scopus citations

  • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

    Kwong, L. N., Costello, J. C., Liu, H., Jiang, S., Helms, T. L., Langsdorf, A. E., Jakubosky, D., Genovese, G., Muller, F. L., Jeong, J. H., Bender, R. P., Chu, G. C., Flaherty, K. T., Wargo, J. A., Collins, J. J. & Chin, L., Oct 2012, In: Nature medicine. 18, 10, p. 1503-1510 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    293 Scopus citations

  • Passenger deletions generate therapeutic vulnerabilities in cancer

    Muller, F. L., Colla, S., Aquilanti, E., Manzo, V. E., Genovese, G., Lee, J., Eisenson, D., Narurkar, R., Deng, P., Nezi, L., Lee, M. A., Hu, B., Hu, J., Sahin, E., Ong, D., Fletcher-Sananikone, E., Ho, D., Kwong, L., Brennan, C., Wang, Y. A., & 2 othersChin, L. & Depinho, R. A., Aug 16 2012, In: Nature. 488, 7411, p. 337-342 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    251 Scopus citations

  • PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

    Izaguirre, D. I., Zhu, W., Hai, T., Cheung, H. C., Krahe, R. & Cote, G. J., Nov 2012, In: Molecular Carcinogenesis. 51, 11, p. 895-906 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    67 Scopus citations