Genomic Medicine

Search results

  • 2013

    Neutralization of terminal differentiation in gliomagenesis

    Hu, J., Ho, A. L., Yuan, L., Hu, B., Hua, S., Hwang, S. S., Zhang, J., Hu, T., Zheng, H., Gan, B., Wu, G., Wang, Y. A., Chin, L. & DePinho, R. A., Sep 3 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. 14520-14527 8 p.

    Research output: Contribution to journal › Article › peer-review

    63 Scopus citations

  • Nozzle: A report generation toolkit for data analysis pipelines

    Gehlenborg, N., Noble, M. S., Getz, G., Chin, L. & Park, P. J., Apr 15 2013, In: Bioinformatics. 29, 8, p. 1089-1091 3 p.

    Research output: Contribution to journal › Article › peer-review

    17 Scopus citations

  • NPMc+ and FLT3-ITD mutations cooperate in inducing acute leukaemia in a novel mouse model

    Mallardo, M., Caronno, A., Pruneri, G., Raviele, P. R., Viale, A., Pelicci, P. G. & Colombo, E., Nov 2013, In: Leukemia. 27, 11, p. 2248-2251 4 p.

    Research output: Contribution to journal › Letter › peer-review

    38 Scopus citations

  • Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex

    Wise, J. F., Berkova, Z., Mathur, R., Zhu, H., Braun, F. K., Tao, R. H., Sabichi, A. L., Ao, X., Maeng, H. & Samaniego, F., Jun 6 2013, In: Blood. 121, 23, p. 4729-4739 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    68 Scopus citations

  • Overview of the cancer genome atlas project

    Tsou, P. L. & Wu, C. J., Feb 2013, In: Journal of Internal Medicine of Taiwan. 24, 1, p. 43-47 5 p.

    Research output: Contribution to journal › Review article › peer-review

  • P63 steps into the limelight: Crucial roles in the suppression of tumorigenesis and metastasis

    Su, X., Chakravarti, D. & Flores, E. R., Feb 2013, In: Nature Reviews Cancer. 13, 2, p. 136-143 8 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    118 Scopus citations

  • PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis

    Jun, S., Lee, S., Kim, H. C., Ng, C., Schneider, A. M., Ji, H., Ying, H., Wang, H., DePinho, R. A. & Park, J. I., 2013, In: Cell Reports. 5, 2, p. 314-322 9 p.

    Research output: Contribution to journal › Article › peer-review

    38 Scopus citations

  • Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment

    Zhang, Y., Chen, L. Y., Han, X., Xie, W., Kim, H., Yang, D., Liu, D. & Songyang, Z., Apr 2 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5457-5462 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    57 Scopus citations

  • Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds

    Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., Zhao, T., Ye, J., Yang, W., Liu, K., Ge, J., Xu, J., Zhang, Q., Zhao, Y. & Deng, H., 2013, In: Science. 341, 6146, p. 651-654 4 p.

    Research output: Contribution to journal › Article › peer-review

    1088 Scopus citations

  • Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

    Verhaak, R. G. W., Tamayo, P., Yang, J. Y., Hubbard, D., Zhang, H., Creighton, C. J., Fereday, S., Lawrence, M., Carter, S. L., Mermel, C. H., Kostic, A. D., Etemadmoghadam, D., Saksena, G., Cibulskis, K., Duraisamy, S., Levanon, K., Sougnez, C., Tsherniak, A., Gomez, S., Onofrio, R., & 21 othersGabriel, S., Chin, L., Zhang, N., Spellman, P. T., Zhang, Y., Akbani, R., Hoadley, K. A., Kahn, A., Köbel, M., Huntsman, D., Soslow, R. A., Defazio, A., Birrer, M. J., Gray, J. W., Weinstein, J. N., Bowtell, D. D., Drapkin, R., Mesirov, J. P., Getz, G., Levine, D. A. & Meyerson, M., Jan 2 2013, In: Journal of Clinical Investigation. 123, 1, p. 517-525 9 p.

    Research output: Contribution to journal › Article › peer-review

    455 Scopus citations

  • Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

    Du, W., Yi, Y., Zhang, H., Bergholz, J., Wu, J., Ying, H., Zhang, Y. & Xiao, Z. X. J., Apr 30 2013, In: PloS one. 8, 4, e63179.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations

  • Recapitulating human cancer in a mouse

    Chin, L., De Sauvage, F., Egeblad, M., Olive, K. P., Tuveson, D. & Weiss, W., May 2013, In: Nature biotechnology. 31, 5, p. 392-395 4 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    5 Scopus citations

  • Semiconductor-based DNA sequencing of histone modification states

    Cheng, C. S., Rai, K., Garber, M., Hollinger, A., Robbins, D., Anderson, S., Macbeth, A., Tzou, A., Carneiro, M. O., Raychowdhury, R., Russ, C., Hacohen, N., Gershenwald, J. E., Lennon, N., Nusbaum, C., Chin, L., Regev, A. & Amit, I., Oct 25 2013, In: Nature communications. 4, 2672.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Single-cell paired-end genome sequencing reveals structural variation per cell cycle

    Voet, T., Kumar, P., Van Loo, P., Cooke, S. L., Marshall, J., Lin, M. L., Esteki, M. Z., Van Der Aa, N., Mateiu, L., McBride, D. J., Bignell, G. R., McLaren, S., Teague, J., Butler, A., Raine, K., Stebbings, L. A., Quail, M. A., D'Hooghe, T., Moreau, Y., Futreal, P. A., & 3 othersStratton, M. R., Vermeesch, J. R. & Campbell, P. J., Jul 2013, In: Nucleic acids research. 41, 12, p. 6119-6138 20 p.

    Research output: Contribution to journal › Article › peer-review

    124 Scopus citations

  • Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion

    Vanderslice, P., Biediger, R. J., Woodside, D. G., Brown, W. S., Khounlo, S., Warier, N. D., Gundlach IV, C. W., Caivano, A. R., Bornmann, W. G., Maxwell, D. S., McIntyre, B. W., Willerson, J. T. & Dixon, R. A. F., Jul 5 2013, In: Journal of Biological Chemistry. 288, 27, p. 19414-19428 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

    Aguirre-Gamboa, R., Gomez-Rueda, H., Martínez-Ledesma, E., Martínez-Torteya, A., Chacolla-Huaringa, R., Rodriguez-Barrientos, A., Tamez-Peña, J. G. & Treviño, V., Sep 16 2013, In: PloS one. 8, 9, e74250.

    Research output: Contribution to journal › Article › peer-review

    579 Scopus citations

  • The cancer genome atlas pan-cancer analysis project

    Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Sander, C., Stuart, J. M., Chang, K., Creighton, C. J., Davis, C., Donehower, L., Drummond, J., Wheeler, D., Ally, A., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chu, A., Chuah, E., & 316 othersChun, H. J. E., Dhalla, N., Guin, R., Hirst, M., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Robertson, A. G., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Varhol, R. J., Beroukhim, R., Bhatt, A. S., Brooks, A. N., Cherniack, A. D., Freeman, S. S., Gabriel, S. B., Helman, E., Jung, J., Meyerson, M., Ojesina, A. I., Pedamallu, C. S., Saksena, G., Schumacher, S. E., Tabak, B., Zack, T., Lander, E. S., Bristow, C. A., Hadjipanayis, A., Haseley, P., Kucherlapati, R., Lee, S., Lee, E., Luquette, L. J., Mahadeshwar, H. S., Pantazi, A., Parfenov, M., Park, P. J., Protopopov, A., Ren, X., Santoso, N., Seidman, J., Seth, S., Song, X., Tang, J., Xi, R., Xu, A. W., Yang, L., Zeng, D., Auman, J. T., Balu, S., Buda, E., Fan, C., Hoadley, K. A., Jones, C. D., Meng, S., Mieczkowski, P. A., Parker, J. S., Perou, C. M., Roach, J., Shi, Y., Silva, G. O., Tan, D., Veluvolu, U., Waring, S., Wilkerson, M. D., Wu, J., Zhao, W., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jeffreys, S. R., Mose, L. E., Simons, J. V., Soloway, M. G., Baylin, S. B., Berman, B. P., Bootwalla, M. S., Danilova, L., Herman, J. G., Hinoue, T., Laird, P. W., Rhie, S. K., Shen, H., Triche, T., Weisenberger, D. J., Carter, S. L., Cibulskis, K., Chin, L., Zhang, J., Sougnez, C., Wang, M., Getz, G., Dinh, H., Doddapaneni, H. V., Gibbs, R., Gunaratne, P., Han, Y., Kalra, D., Kovar, C., Lewis, L., Morgan, M., Morton, D., Muzny, D., Reid, J., Xi, L., Cho, J., Dicara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Liu, Y., Noble, M. S., Stojanov, P., Voet, D., Zhang, H., Zou, L., Stewart, C., Bernard, B., Bressler, R., Eakin, A., Iype, L., Knijnenburg, T., Kramer, R., Kreisberg, R., Leinonen, K., Lin, J., Liu, Y., Miller, M., Reynolds, S. M., Rovira, H., Shmulevich, I., Thorsson, V., Yang, D., Zhang, W., Amin, S., Wu, C. J., Wu, C. C., Akbani, R., Aldape, K., Baggerly, K. A., Broom, B., Casasent, T. D., Cleland, J., Dodda, D., Edgerton, M., Han, L., Herbrich, S. M., Ju, Z., Kim, H., Lerner, S., Li, J., Liang, H., Liu, W., Lorenzi, P. L., Lu, Y., Melott, J., Nguyen, L., Su, X., Verhaak, R., Wang, W., Wong, A., Yang, Y., Yao, J., Yao, R., Yoshihara, K., Yuan, Y., Yung, A. K., Zhang, N., Zheng, S., Ryan, M., Kane, D. W., Aksoy, B. A., Ciriello, G., Dresdner, G., Gao, J., Gross, B., Jacobsen, A., Kahles, A., Ladanyi, M., Lee, W., Lehmann, K. V., Miller, M. L., Ramirez, R., Rätsch, G., Reva, B., Schultz, N., Senbabaoglu, Y., Shen, R., Sinha, R., Sumer, S. O., Sun, Y., Taylor, B. S., Weinhold, N., Fei, S., Spellman, P., Benz, C., Carlin, D., Cline, M., Craft, B., Goldman, M., Haussler, D., Ma, S., Ng, S., Paull, E., Radenbaugh, A., Salama, S., Sokolov, A., Swatloski, T., Uzunangelov, V., Waltman, P., Yau, C., Zhu, J., Hamilton, S. R., Abbott, S., Abbott, R., Dees, N. D., Delehaunty, K., Ding, L., Dooling, D. J., Eldred, J. M., Fronick, C. C., Fulton, R., Fulton, L. L., Kalicki-Veizer, J., Kanchi, K. L., Kandoth, C., Koboldt, D. C., Larson, D. E., Ley, T. J., Lin, L., Lu, C., Magrini, V. J., Mardis, E. R., McLellan, M. D., McMichael, J. F., Miller, C. A., O'Laughlin, M., Pohl, C., Schmidt, H., Smith, S. M., Walker, J., Wallis, J. W., Wendl, M. C., Wilson, R. K., Wylie, T., Zhang, Q., Burton, R., Jensen, M. A., Kahn, A., Pihl, T., Pot, D., Wan, Y., Levine, D. A., Black, A. D., Bowen, J., Frick, J., Gastier-Foster, J. M., Harper, H. A., Helsel, C., Leraas, K. M., Lichtenberg, T. M., McAllister, C., Ramirez, N. C., Sharpe, S., Wise, L., Zmuda, E., Chanock, S. J., Davidsen, T., Demchok, J. A., Eley, G., Felau, I., Sheth, M., Sofia, H., Staudt, L., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J., Omberg, L., Margolin, A., Raphael, B. J., Vandin, F., Wu, H. T., Leiserson, M. D. M., Benz, S. C., Vaske, C. J., Noushmehr, H., Wolf, D., Veer, L. V. T., Anastassiou, D., Yang, T. H. O., Lopez-Bigas, N., Gonzalez-Perez, A., Tamborero, D., Xia, Z., Li, W., Cho, D. Y., Przytycka, T., Hamilton, M., McGuire, S., Nelander, S., Johansson, P., Jörnsten, R. & Kling, T., Oct 1 2013, In: Nature Genetics. 45, 10, p. 1113-1120 8 p.

    Research output: Contribution to journal › Article › peer-review

    5099 Scopus citations

  • The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

    Yen, J., White, R. M., Wedge, D. C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I. R., Wu, C. J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., & 20 othersWhitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O'Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D. J., Zon, L. I., Patton, E. E., Stemple, D. L. & Futreal, P. A., Oct 23 2013, In: Genome biology. 14, 10, R113.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model

    Pizzimenti, S., Ciamporcero, E., Pettazzoni, P., Osella-Abate, S., Novelli, M., Toaldo, C., Husse, M., Daga, M., Minelli, R., Bisazza, A., Ferruti, P., Ranucci, E., Grazia Bernengo, M., Dianzani, C., Biasi, F., Cavalli, R. & Barrera, G., 2013, In: Free Radical Biology and Medicine. 65, p. 765-777 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • The somatic genomic landscape of glioblastoma

    TCGA Research Network, Oct 10 2013, In: Cell. 155, 2, p. 462 1 p.

    Research output: Contribution to journal › Article › peer-review

    3506 Scopus citations

  • The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells

    Marangoni, F., Murooka, T. T., Manzo, T., Kim, E. Y., Carrizosa, E., Elpek, N. M. & Mempel, T. R., Feb 21 2013, In: Immunity. 38, 2, p. 237-249 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    126 Scopus citations

  • The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

    Wan, M., Liang, J., Xiong, Y., Shi, F., Zhang, Y., Lu, W., He, Q., Yang, D., Chen, R., Liu, D., Barton, M. & Songyang, Z., Feb 15 2013, In: Journal of Biological Chemistry. 288, 7, p. 5039-5048 10 p.

    Research output: Contribution to journal › Article › peer-review

    60 Scopus citations

  • Tumor-targeting vaccination instructs graft-vs.-tumor immune responses

    Manzo, T., Michelini, R. H., Sturmheit, T., Basso, V., Bellone, M. & Mondino, A., 2013, In: OncoImmunology. 2, 10, e25996.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Vaccine-instructed intratumoral IFN-g enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation

    Michelini, R. H., Manzo, T., Sturmheit, T., Basso, V., Rocchi, M., Freschi, M., Listopad, J., Blankenstein, T., Bellone, M. & Mondino, A., Aug 1 2013, In: Cancer Research. 73, 15, p. 4641-4652 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Whole exome sequencing of adenoid cystic carcinoma

    Stephens, P. J., Davies, H. R., Mitani, Y., Van Loo, P., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Cheverton, A., Bignell, G. R., Butler, A. P., Gamble, J., Gamble, S., Hardy, C., Hinton, J., Jia, M., Jayakumar, A., Jones, D., Latimer, C., McLaren, S., McBride, D. J., & 16 othersMenzies, A., Mudie, L., Maddison, M., Raine, K., Nik-Zainal, S., O'Meara, S., Teague, J. W., Varela, I., Wedge, D. C., Whitmore, I., Lippman, S. M., McDermott, U., Stratton, M. R., Campbell, P. J., El-Naggar, A. K. & Futreal, P. A., Jul 1 2013, In: Journal of Clinical Investigation. 123, 7, p. 2965-2968 4 p.

    Research output: Contribution to journal › Article › peer-review

    215 Scopus citations

  • XAcetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis

    Qian, M. X., Pang, Y., Liu, C. H., Haratake, K., Du, B. Y., Ji, D. Y., Wang, G. F., Zhu, Q. Q., Song, W., Yu, Y., Zhang, X. X., Huang, H. T., Miao, S., Chen, L. B., Zhang, Z. H., Liang, Y. N., Liu, S., Cha, H., Yang, D., Zhai, Y., & 12 othersKomatsu, T., Tsuruta, F., Li, H., Cao, C., Li, W., Li, G. H., Cheng, Y., Chiba, T., Wang, L., Goldberg, A. L., Shen, Y. & Qiu, X. B., May 23 2013, In: Cell. 153, 5, p. 1012 1 p.

    Research output: Contribution to journal › Article › peer-review

    244 Scopus citations

  • ZNF365 promotes stability of fragile sites and telomeres

    Zhang, Y., Shin, S. J., Liu, D., Ivanova, E., Foerster, F., Ying, H., Zheng, H., Xiao, Y., Chen, Z., Protopopov, A., DePinho, R. A. & Paik, J. H., Jul 2013, In: Cancer discovery. 3, 7, p. 798-811 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations
  • 2014

    A case of pathological complete response with neoadjuvant XELOX chemotherapy for locally advanced rectal cancer

    Kitahara, T., Takemasa, I., Inoue, A., Osawa, H., Miyo, M., Mokutani, Y., Ogawa, H., Naito, A., Hamabe, A., Hiraki, M., Munakata, K., Uemura, M., Nishimura, J., Hata, T., Mizushima, T., Yamamoto, H., Doki, Y. & Mori, M., Nov 2014, In: Japanese Journal of Cancer and Chemotherapy. 41, 12, p. 1569-1571 3 p.

    Research output: Contribution to journal › Article › peer-review

  • A case of solitary fibrous tumor from the greater omentum resected via laparoscopic surgery

    Osawa, H., Nishimura, J., Inoue, A., Ueda, M., Mokutani, Y., Miyo, M., Naito, A., Hamabe, A., Hiraki, M., Matsumura, T., Munakata, K., Ogino, T., Takahashi, Y., Uemura, M., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Doki, Y. & Mori, M., Nov 2014, In: Japanese Journal of Cancer and Chemotherapy. 41, 12, p. 2493-2495 3 p.

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations

  • A long type of TBCK is a novel cytoplasmic and mitotic apparatus-associated protein likely suppressing cell proliferation

    Wu, J., Li, Q., Li, Y., Lin, J., Yang, D., Zhu, G., Wang, L., He, D., Lu, G. & Zeng, C., Feb 20 2014, In: Journal of Genetics and Genomics. 41, 2, p. 69-72 4 p.

    Research output: Contribution to journal › Letter › peer-review

    11 Scopus citations

  • Application of statistical machine learning in identifying candidate biomarkers of resistant to anti-cancer drugs in ovarian cancer

    Nabavi, S., Maitituoheti, M., Yamada, M. & Tonellato, P., Dec 2 2014, Proceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014. Institute of Electrical and Electronics Engineers Inc., 6972886. (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; vol. 2014-December).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

    2 Scopus citations

  • Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    Liu, P., Begley, M., Michowski, W., Inuzuka, H., Ginzberg, M., Gao, D., Tsou, P., Gan, W., Papa, A., Kim, B. M., Wan, L., Singh, A., Zhai, B., Yuan, M., Wang, Z., Gygi, S. P., Lee, T. H., Lu, K. P., Toker, A., Pandolfi, P. P., & 5 othersAsara, J. M., Kirschner, M. W., Sicinski, P., Cantley, L. & Wei, W., 2014, In: Nature. 508, 7497, p. 541-545 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    265 Scopus citations

  • Characterization of HPV and host genome interactions in primary head and neck cancers

    The Cancer Genome Atlas Network, Oct 28 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15544-15549 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    282 Scopus citations

  • Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions

    Kwong, L. N. & Chin, L., Mar 15 2014, In: Cancer Research. 74, 6, p. 1814-1821 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    15 Scopus citations

  • Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics

    Frederick, D. T., Salas Fragomeni, R. A., Schalck, A., Ferreiro-Neira, I., Hoff, T., Cooper, Z. A., Haq, R., Panka, D. J., Kwong, L. N., Davies, M. A., Cusack, J. C., Flaherty, K. T., Fisher, D. E., Mier, J. W., Wargo, J. A. & Sullivan, R. J., Jul 1 2014, In: PloS one. 9, 7, e101286.

    Research output: Contribution to journal › Article › peer-review

    37 Scopus citations

  • Cognitive dysfunction in patients with multiple sclerosis treated with different types of interferon beta: A randomized clinical trial

    Mokhber, N., Azarpazhooh, A., Orouji, E., Rao, S. M., Khorram, B., Sahraian, M. A., Foroghipoor, M., Gharavi, M. M., Kakhi, S., Nikkhah, K. & Azarpazhooh, M. R., Jul 15 2014, In: Journal of the Neurological Sciences. 342, 1-2, p. 16-20 5 p.

    Research output: Contribution to journal › Article › peer-review

    28 Scopus citations

  • Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

    Timsah, Z., Ahmed, Z., Lin, C. C., Melo, F. A., Stagg, L. J., Leonard, P. G., Jeyabal, P., Berrout, J., O'Neil, R. G., Bogdanov, M. & Ladbury, J. E., Feb 2014, In: Nature Structural and Molecular Biology. 21, 2, p. 180-188 9 p.

    Research output: Contribution to journal › Article › peer-review

    41 Scopus citations

  • Comprehensive molecular characterization of gastric adenocarcinoma

    Cancer Genome Atlas Research Network, Sep 11 2014, In: Nature. 513, 7517, p. 202-209 8 p.

    Research output: Contribution to journal › Article › peer-review

    4591 Scopus citations

  • Comprehensive molecular characterization of urothelial bladder carcinoma

    Weinstein, J. N., Akbani, R., Broom, B. M., Wang, W., Verhaak, R. G. W., McConkey, D., Lerner, S., Morgan, M., Creighton, C. J., Smith, C., Cherniack, A. D., Kim, J., Pedamallu, C. S., Noble, M. S., Al-Ahmadie, H. A., Reuter, V. E., Rosenberg, J. E., F.Bajorin, D., Bochner, B. H., Solit, D. B., & 273 othersKoppie, T., Robinson, B., Gordenin, D. A., Fargo, D., Klimczak, L. J., Roberts, S. A., Au, J., Laird, P. W., Hinoue, T., Schultz, N., Ramirez, R., Hansel, D., Hoadley, K. A., Kim, W. Y., Damrauer, J. S., Baylin, S. B., Mungall, A. J., Robertson, A. G., Chu, A., Kwiatkowski, D. J., Sougnez, C., Cibulskis, K., Lichtenstein, L., Sivachenko, A., Stewart, C., Lawrence, M. S., Getz, G., Lander, E., Gabrie, S. B., Donehower, L., Carter, S. L., Saksena, G., Schumacher, S. E., Freeman, S. S., Jung, J., Bhatt, A. S., Pugh, T., Beroukhim, R., Meyerson, M., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Dhalla, N., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Wong, T., Wye, N., Bowlby, R., Chuah, E., Guin, R., Shen, H., Bootwalla, M. S., Triche, T., Lai, P. H., Van Den Berg, D. J., Weisenberger, D. J., Balu, S., Bodenheimer, T., Hoyle, A. P., Jefferys, S. R., Meng, S., Mose, L. E., Simons, J. V., Soloway, M. G., Wu, J., Parker, J. S., Hayes, D. N., Roach, J., Buda, E., Jones, C. D., Mieczkowski, P. A., Tan, D., Veluvolu, U., Waring, S., Auman, J. T., Perou, C. M., Wilkerson, M. D., Santoso, N., Parfenov, M., Ren, X., Pantazi, A., Hadjipanayis, A., Seidman, J., Kucherlapati, R., Lee, S., Yang, L., Park, P. J., Xu, A. W., Protopopov, A., Zhang, J., Bristow, C., Mahadeshwar, H. S., Seth, S., Song, X., Tang, J., Zeng, D., Chin, L., Guo, C., Casasent, T. D., Liu, W., Ju, Z., Motter, T., Peng, B., Ryan, M., Su, X., Yang, J. Y., Lorenzi, P. L., Yao, H., Zhang, N., Zhang, J., Mills, G. B., Cho, J., DiCara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Lin, P., Liu, Y., Stojanov, P., Voet, D., Zhang, H., Zou, L., Bernard, B., Kreisberg, D., Reynolds, S., Rovira, H., Shmulevich, I., Gao, J., Jacobsen, A., Aksoy, B. A., Antipin, Y., Ciriello, G., Dresdner, G., Gross, B., Lee, W., Reva, B., Shen, R., Sinha, R., Sumer, S. O., Weinhold, N., Ladanyi, M., Sander, C., Benz, C., Carlin, D., Haussler, D., Ng, S., Paull, E., Stuart, J., Zhu, J., Liu, Y., Zhang, W., Taylor, B. S., Lichtenberg, T. M., Zmuda, E., Barr, T., Black, A. D., George, M., Hanf, B., Helsel, C., McAllister, C., Ramirez, N. C., Tabler, T. R., Weaver, S., Wise, L., Bowen, J., Gastier-Foster, J. M., Jian, W., Tello, S., Ittman, M., Castro, P., McClenden, W. D., Gibbs, R., Saller, C., Tarvin, K., DiPiero, J. M., Owens, J., Bollag, R., Li, Q., Weinberger, P., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Swanson, P., Shelton, T., Curley, E., Gardner, J., Mallery, D., Penny, R., Van Bang, N., Hanh, P. T., Kohl, B., Van Le, X., Phu, B. D., Thorp, R., Tien, N. V., Vinh, L. Q., Sandusky, G., Burks, E., Christ, K., Gee, J., Holway, A., Moinzadeh, A., Sorcini, A., Sullivan, T., Garcia-Grossman, I. R., Regazzi, A. M., Boice, L., Rathmell, W. K., Thorne, L., Bastacky, S., Davies, B., Dhir, R., Gingrich, J., Hrebinko, R., Maranchie, J., Nelson, J., Parwani, A., Bshara, W., Gaudioso, C., Morrison, C., Alexopoulou, V., Bartlett, J., Engel, J., Kodeeswaran, S., Antic, T., O'Donnell, P. H., Smith, N. D., Steinberg, G. D., Egea, S., Gomez-Fernandez, C., Herbert, L., Jorda, M., Soloway, M., Beaver, A., Carter, S., Kapur, P., Lewis, C., Lotan, Y., Bondaruk, J., Czerniak, B., Skinner, E., Aldape, K., Jensen, M. A., Kahn, A. B., Pihl, T. D., Pot, D. A., Srinivasan, D., Wan, Y., Ferguson, M. L., Zenklusen, J. C., Davidsen, T., Demchok, J. A., Shaw, K. R. M., Sheth, M., Tarnuzzer, R., Wang, Z., Yang, L., Hutter, C., Ozenberger, B. A., Sofia, H. J. & Eley, G., 2014, In: Nature. 507, 7492, p. 315-322 8 p.

    Research output: Contribution to journal › Article › peer-review

    2314 Scopus citations

  • Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network

    Collisson, E. A., Campbell, J. D., Brooks, A. N., Berger, A. H., Lee, W., Chmielecki, J., Beer, D. G., Cope, L., Creighton, C. J., Danilova, L., Ding, L., Getz, G., Hammerman, P. S., Hayes, D. N., Hernandez, B., Herman, J. G., Heymach, J. V., Jurisica, I., Kucherlapati, R., Kwiatkowski, D., & 290 othersLadanyi, M., Robertson, G., Schultz, N., Shen, R., Sinha, R., Sougnez, C., Tsao, M. S., Travis, W. D., Weinstein, J. N., Wigle, D. A., Wilkerson, M. D., Chu, A., Cherniack, A. D., Hadjipanayis, A., Rosenberg, M., Weisenberger, D. J., Laird, P. W., Radenbaugh, A., Ma, S., Stuart, J. M., Byers, L. A., Baylin, S. B., Govindan, R., Meyerson, M., Gabriel, S. B., Cibulskis, K., Kim, J., Stewart, C., Lichtenstein, L., Lander, E. S., Lawrence, M. S., Getz, E., Fulton, R., Fulton, L. L., McLellan, M. D., Wilson, R. K., Ye, K., Fronick, C. C., Maher, C. A., Miller, C. A., Wendl, M. C., Cabanski, C., Mardis, E., Wheeler, D., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Chuah, E., Dhalla, N., Guin, R., Hirst, C., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Varhol, R., Robertson, A. G., Wye, N., Thiessen, N., Holt, R. A., Jones, S. J. M., Marra, M. A., Imielinski, M., Onofrio, R. C., Hodis, E., Zack, T., Helman, E., Pedamallu, C. S., Mesirov, J., Saksena, G., Schumacher, S. E., Carter, S. L., Garraway, L., Beroukhim, R., Lee, S., Mahadeshwar, H. S., Pantazi, A., Protopopov, A., Ren, X., Seth, S., Song, X., Tang, J., Yang, L., Zhang, J., Chen, P. C., Parfenov, M., Xu, A. W., Santoso, N., Chin, L., Park, P. J., Hoadley, K. A., Auman, J. T., Meng, S., Shi, Y., Buda, E., Waring, S., Veluvolu, U., Tan, D., Mieczkowski, P. A., Jones, C. D., Simons, J. V., Soloway, M. G., Bodenheimer, T., Jefferys, S. R., Roach, J., Hoyle, A. P., Wu, J., Balu, S., Singh, D., Prins, J. F., Marron, J. S., Parker, J. S., Perou, C. M., Liu, J., Maglinte, D. T., Lai, P. H., Bootwalla, M. S., Van Den Berg, D. J., Triche, T., Cho, J., DiCara, D., Heiman, D., Lin, P., Mallard, W., Voet, D., Zhang, H., Zou, L., Noble, M. S., Gehlenborg, N., Thorvaldsdottir, H., Nazaire, M. D., Robinson, J., Aksoy, B. A., Ciriello, G., Taylor, B. S., Dresdner, G., Gao, J., Gross, B., Seshan, V. E., Reva, B., Sumer, S. O., Weinhold, N., Sander, C., Ng, S., Zhu, J., Benz, C. C., Yau, C., Haussler, D., Spellman, P. T., Kimes, P. K., Broom, B. M., Wang, J., Lu, Y., Ng, P. K. S., Diao, L., Liu, W., Amos, C. I., Akbani, R., Mills, G. B., Curley, E., Paulauskis, J., Lau, K., Morris, S., Shelton, T., Mallery, D., Gardner, J., Penny, R., Saller, C., Tarvin, K., Richards, W. G., Cerfolio, R., Bryant, A., Raymond, D. P., Pennell, N. A., Farver, C., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Brown, J., Bauer, T., Dolzhanskiy, C. O., Potapova, O., Rotin, D., Voronina, O., Nemirovich-Danchenko, E., Fedosenko, K. V., Gal, A., Behera, M., Ramalingam, S. S., Sica, G., Flieder, D., Boyd, J., Weaver, J. E., Kohl, B., Thinh, D. H. Q., Sandusky, G., Juhl, H., Duhig, E., Illei, P., Gabrielson, E., Shin, J., Lee, B., Rogers, K., Trusty, D., Brock, M. V., Williamson, C., Burks, E., Rieger-Christ, K., Holway, A., Sullivan, T., Asiedu, M. K., Kosari, F., Rekhtman, N., Zakowski, M., Rusch, V. W., Zippile, P., Suh, J., Pass, H., Goparaju, C., Owusu-Sarpong, Y., Bartlett, J. M. S., Kodeeswaran, S., Parfitt, J., Sekhon, H., Albert, M., Eckman, J., Myers, J. B., Morrison, C., Gaudioso, C., Borgia, J. A., Bonomi, P., Pool, M., Liptay, M. J., Moiseenko, F., Zaytseva, I., Dienemann, H., Meister, M., Schnabel, P. A., Muley, T. R., Peifer, M., Gomez-Fernandez, C., Herbert, L., Egea, S., Huang, M., Thorne, L. B., Boice, L., Salazar, A. H., Funkhouser, W. K., Rathmell, W. K., Dhir, R., Yousem, S. A., Dacic, S., Schneider, F., Siegfried, J. M., Hajek, R., Watson, M. A., McDonald, S., Meyers, B., Clarke, B., Yang, I. A., Fong, K. M., Hunter, L., Windsor, M., Bowman, R. V., Peters, S., Letovanec, I., Khan, K. Z., Jensen, M. A., Snyder, E. E., Srinivasan, D., Kahn, A. B., Baboud, J., Pot, D. A., Shaw, K. R. M., Sheth, M., Davidsen, T., Demchok, J. A., Yang, L., Wang, Z., Tarnuzzer, R., Zenklusen, J. C., Ozenberger, B. A., Sofia, H. J. & Cheney, R., 2014, In: Nature. 511, 7511, p. 543-550 8 p.

    Research output: Contribution to journal › Article › peer-review

    3986 Scopus citations

  • Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)

    Peng, Z., Maxwell, D. S., Sun, D., Bhanu Prasad, B. A., Schuber, P. T., Pal, A., Ying, Y., Han, D., Gao, L., Wang, S., Levitzki, A., Kapuria, V., Talpaz, M., Young, M., Showalter, H. D., Donato, N. J. & Bornmann, W. G., Feb 15 2014, In: Bioorganic and Medicinal Chemistry. 22, 4, p. 1450-1458 9 p.

    Research output: Contribution to journal › Article › peer-review

    12 Scopus citations

  • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

    Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C. C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., DeJesus-Acosta, A., Sharma, P., Heidari, P., Mahmood, U., Chin, L., Moses, H. L., Weaver, V. M., Maitra, A., Allison, J. P., LeBleu, V. S., & 1 othersKalluri, R., Jun 16 2014, In: Cancer cell. 25, 6, p. 719-734 16 p.

    Research output: Contribution to journal › Article › peer-review

    1744 Scopus citations

  • Design and synthesis of an inositol phosphate analog based on computational docking studies

    Peng, Z., Maxwell, D., Sun, D., Ying, Y., Schuber, P. T., Bhanu Prasad, B. A., Gelovani, J., Alfred Yung, W. K. & Bornmann, W. G., Jan 28 2014, In: Tetrahedron. 70, 4, p. 984-990 7 p.

    Research output: Contribution to journal › Article › peer-review

    4 Scopus citations

  • Development of a novel transgenic rice with hypocholesterolemic activity via high-level accumulation of the α′ subunit of soybean β-conglycinin

    Cabanos, C., Kato, N., Amari, Y., Fujiwara, K., Ohno, T., Shimizu, K., Goto, T., Shimada, M., Kuroda, M., Masuda, T., Takaiwa, F., Utsumi, S., Nagaoka, S. & Maruyama, N., Aug 2014, In: Transgenic Research. 23, 4, p. 609-620 12 p.

    Research output: Contribution to journal › Article › peer-review

    12 Scopus citations

  • Differential and limited expression of mutant alleles in multiple myeloma

    Rashid, N. U., Sperling, A. S., Bolli, N., Wedge, D. C., Van Loo, P., Tai, Y. T., Shammas, M. A., Fulciniti, M., Samur, M. K., Richardson, P. G., Magrangeas, F., Minvielle, S., Futreal, P. A., Anderson, K. C., Avet-Loiseau, H., Campbell, P. J., Parmigiani, G. & Munshi, N. C., Nov 13 2014, In: Blood. 124, 20, p. 3110-3117 8 p.

    Research output: Contribution to journal › Article › peer-review

    47 Scopus citations

  • Differential expression and elution behavior of basic 7S globulin among cultivars under hot water treatment of soybean seeds

    Fujiwara, K., Cabanos, C., Toyota, K., Kobayashi, Y. & Maruyama, N., Jun 2014, In: Journal of Bioscience and Bioengineering. 117, 6, p. 742-748 7 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Drug delivery nanoparticles in skin cancers

    Dianzani, C., Zara, G. P., Maina, G., Pettazzoni, P., Pizzimenti, S., Rossi, F., Gigliotti, C. L., Ciamporcero, E. S., Daga, M. & Barrera, G., 2014, In: BioMed research international. 2014, 895986.

    Research output: Contribution to journal › Review article › peer-review

    124 Scopus citations

  • Efficacy of vemurafenib in a trametinib-resistant stage IV melanoma patient-letter

    Bernhardt, M., Orouji, E., Larribere, L., Gebhardt, C. & Utikal, J., May 1 2014, In: Clinical Cancer Research. 20, 9, p. 2498-2499 2 p.

    Research output: Contribution to journal › Letter › peer-review

    3 Scopus citations

  • Enterococcus faecalis reconfigures its transcriptional regulatory network activation at different copper levels

    Latorre, M., Galloway-Peña, J., Roh, J. H., Budinich, M., Reyes-Jara, A., Murray, B. E., Maass, A. & González, M., Mar 2014, In: Metallomics. 6, 3, p. 572-581 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Erratum: Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone (Nature Genetics (2014) 45 (1479-1482))

    Behjati, S., Tarpey, P. S., Presneau, N., Scheipl, S., Pillay, N., Van Loo, P., Wedge, D. C., Cooke, S. L., Gundem, G., Davies, H., Nik-Zainal, S., Martin, S., Mclaren, S., Goodie, V., Robinson, B., Butler, A., Teague, J. W., Halai, D., Khatri, B., Myklebost, O., & 9 othersBaumhoer, D., Jundt, G., Hamoudi, R., Tirabosco, R., Amary, M. F., Futreal, P. A., Stratton, M. R., Campbell, P. J. & Flanagan, A. M., Mar 2014, In: Nature Genetics. 46, 3, p. 316 1 p.

    Research output: Contribution to journal › Comment/debate › peer-review

    1 Scopus citations