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  • 2013

    The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

    Wan, M., Liang, J., Xiong, Y., Shi, F., Zhang, Y., Lu, W., He, Q., Yang, D., Chen, R., Liu, D., Barton, M. & Songyang, Z., Feb 15 2013, In: Journal of Biological Chemistry. 288, 7, p. 5039-5048 10 p.

    Research output: Contribution to journal › Article › peer-review

    60 Scopus citations

  • Tumor-targeting vaccination instructs graft-vs.-tumor immune responses

    Manzo, T., Michelini, R. H., Sturmheit, T., Basso, V., Bellone, M. & Mondino, A., 2013, In: OncoImmunology. 2, 10, e25996.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Vaccine-instructed intratumoral IFN-g enables regression of autochthonous mouse prostate cancer in allogeneic T-cell transplantation

    Michelini, R. H., Manzo, T., Sturmheit, T., Basso, V., Rocchi, M., Freschi, M., Listopad, J., Blankenstein, T., Bellone, M. & Mondino, A., Aug 1 2013, In: Cancer Research. 73, 15, p. 4641-4652 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Whole exome sequencing of adenoid cystic carcinoma

    Stephens, P. J., Davies, H. R., Mitani, Y., Van Loo, P., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Cheverton, A., Bignell, G. R., Butler, A. P., Gamble, J., Gamble, S., Hardy, C., Hinton, J., Jia, M., Jayakumar, A., Jones, D., Latimer, C., McLaren, S., McBride, D. J., & 16 othersMenzies, A., Mudie, L., Maddison, M., Raine, K., Nik-Zainal, S., O'Meara, S., Teague, J. W., Varela, I., Wedge, D. C., Whitmore, I., Lippman, S. M., McDermott, U., Stratton, M. R., Campbell, P. J., El-Naggar, A. K. & Futreal, P. A., Jul 1 2013, In: Journal of Clinical Investigation. 123, 7, p. 2965-2968 4 p.

    Research output: Contribution to journal › Article › peer-review

    215 Scopus citations

  • XAcetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis

    Qian, M. X., Pang, Y., Liu, C. H., Haratake, K., Du, B. Y., Ji, D. Y., Wang, G. F., Zhu, Q. Q., Song, W., Yu, Y., Zhang, X. X., Huang, H. T., Miao, S., Chen, L. B., Zhang, Z. H., Liang, Y. N., Liu, S., Cha, H., Yang, D., Zhai, Y., & 12 othersKomatsu, T., Tsuruta, F., Li, H., Cao, C., Li, W., Li, G. H., Cheng, Y., Chiba, T., Wang, L., Goldberg, A. L., Shen, Y. & Qiu, X. B., May 23 2013, In: Cell. 153, 5, p. 1012 1 p.

    Research output: Contribution to journal › Article › peer-review

    244 Scopus citations

  • ZNF365 promotes stability of fragile sites and telomeres

    Zhang, Y., Shin, S. J., Liu, D., Ivanova, E., Foerster, F., Ying, H., Zheng, H., Xiao, Y., Chen, Z., Protopopov, A., DePinho, R. A. & Paik, J. H., Jul 2013, In: Cancer discovery. 3, 7, p. 798-811 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations
  • 2012

    AACR Cancer Progress Report 2012.

    Cantley, L. C., Dalton, W. S., DuBois, R. N., Finn, O. J., Futreal, P. A., Golub, T. R., Hait, W. N., Lozano, G., Maris, J. M., Nelson, W. G., Sawyers, C. L., Schreiber, S. L., Spitz, M. R. & Steeg, P. S., Nov 1 2012, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 18, 21 Suppl, p. S1-100

    Research output: Contribution to journal › Article › peer-review

    19 Scopus citations

  • A case of advanced gastrointestinal stromal tumor successfully resected after neoadjuvant chemotherapy with imatinib mesylate

    Inoue, A., Koshiishi, N., Kinuta, S., Maruyama, S. & Tsujiyama, A., 2012, In: Japanese Journal of Gastroenterological Surgery. 45, 9, p. 944-951 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A landscape of driver mutations in melanoma

    Hodis, E., Watson, I. R., Kryukov, G. V., Arold, S. T., Imielinski, M., Theurillat, J. P., Nickerson, E., Auclair, D., Li, L., Place, C., Dicara, D., Ramos, A. H., Lawrence, M. S., Cibulskis, K., Sivachenko, A., Voet, D., Saksena, G., Stransky, N., Onofrio, R. C., Winckler, W., & 20 othersArdlie, K., Wagle, N., Wargo, J., Chong, K., Morton, D. L., Stemke-Hale, K., Chen, G., Noble, M., Meyerson, M., Ladbury, J. E., Davies, M. A., Gershenwald, J. E., Wagner, S. N., Hoon, D. S. B., Schadendorf, D., Lander, E. S., Gabriel, S. B., Getz, G., Garraway, L. A. & Chin, L., Jul 20 2012, In: Cell. 150, 2, p. 251-263 13 p.

    Research output: Contribution to journal › Article › peer-review

    1996 Scopus citations

  • Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties

    Bragado, P., Estrada, Y., Sosa, M. S., Avivar-Valderas, A., Cannan, D., Genden, E., Teng, M., Ranganathan, A. C., Wen, H. C., Kapoor, A., Bernstein, E. & Aguirre-Ghiso, J. A., Jan 20 2012, In: PloS one. 7, 1, e29974.

    Research output: Contribution to journal › Article › peer-review

    25 Scopus citations

  • Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer

    Hu, J., Hwang, S. S., Liesa, M., Gan, B., Sahin, E., Jaskelioff, M., Ding, Z., Ying, H., Boutin, A. T., Zhang, H., Johnson, S., Ivanova, E., Kost-Alimova, M., Protopopov, A., Wang, Y. A., Shirihai, O. S., Chin, L. & Depinho, R. A., Feb 17 2012, In: Cell. 148, 4, p. 651-663 13 p.

    Research output: Contribution to journal › Article › peer-review

    221 Scopus citations

  • AS601245, an anti-inflammatory JNK inhibitor, and clofibrate have a synergistic effect in inducing cell responses and in affecting the gene expression profile in CaCo-2 colon cancer cells

    Cerbone, A., Toaldo, C., Pizzimenti, S., Pettazzoni, P., Dianzani, C., Minelli, R., Ciamporcero, E., Roma, G., Dianzani, M. U., Canaparo, R., Ferretti, C. & Barrera, G., 2012, In: PPAR Research. 269751.

    Research output: Contribution to journal › Article › peer-review

    24 Scopus citations

  • Association between HLA-DQB1 gene and patients with acute lymphoblastic leukemia (ALL)

    Orouji, E., Afshari, J. T., Badiee, Z., Shirdel, A. & Alipour, A., May 2012, In: International journal of hematology. 95, 5, p. 551-555 5 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion

    Hill, C. R., Sanchez, N. S., Love, J. D., Arrieta, J. A., Hong, C. C., Brown, C. B., Austin, A. F. & Barnett, J. V., May 2012, In: Cellular Signalling. 24, 5, p. 1012-1022 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    34 Scopus citations

  • CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl

    Bao, M., Hanabuchi, S., Facchinetti, V., Du, Q., Bover, L., Plumas, J., Chaperot, L., Cao, W., Qin, J., Sun, S. C. & Liu, Y. J., Jul 15 2012, In: Journal of Immunology. 189, 2, p. 786-792 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells

    Minelli, R., Serpe, L., Pettazzoni, P., Minero, V., Barrera, G., Gigliotti, C. L., Mesturini, R., Rosa, A. C., Gasco, P., Vivenza, N., Muntoni, E., Fantozzi, R., Dianzani, U., Zara, G. P. & Dianzani, C., May 2012, In: British Journal of Pharmacology. 166, 2, p. 587-601 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    47 Scopus citations

  • Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels

    Lustgarten, M. S., Bhattacharya, A., Muller, F. L., Jang, Y. C., Shimizu, T., Shirasawa, T., Richardson, A. & Van Remmen, H., Jun 8 2012, In: Biochemical and biophysical research communications. 422, 3, p. 515-521 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    67 Scopus citations

  • Comprehensive genomic characterization of squamous cell lung cancers

    Hammerman, P. S., Voet, D., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Getz, G., Imielinski, M., Helman, E., Hernandez, B., Pho, N. H., Meyerson, M., Chu, A., Hye-Chun, J. E., Mungall, A. J., & 316 othersPleasance, E., Robertson, A. G., Sipahimalani, P., Stoll, D., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chuah, E., Coope, R. J. N., Corbett, R., Dhalla, N., Guin, R., He, A., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, K., Nip, K. M., Olshen, A., Schein, J. E., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R., Zeng, T., Zhao, Y., Jones, S. J. M., Marra, M. A., Saksena, G., Cherniack, A. D., Schumacher, S. E., Tabak, B., Carter, S. L., Nguyen, H., Onofrio, R. C., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Protopopov, A., Zhang, J., Hadjipanayis, A., Lee, S., Xi, R., Yang, L., Ren, X., Zhang, H., Shukla, S., Chen, P. C., Haseley, P., Lee, E., Chin, L., Park, P. J., Kucherlapati, R., Socci, N. D., Liang, Y., Schultz, N., Borsu, L., Lash, A. E., Viale, A., Sander, C., Ladanyi, M., Auman, J. T., Hoadley, K. A., Wilkerson, M. D., Shi, Y., Liquori, C., Meng, S., Li, L., Turman, Y. J., Topal, M. D., Tan, D., Waring, S., Buda, E., Walsh, J., Jones, C. D., Mieczkowski, P. A., Singh, D., Wu, J., Gulabani, A., Dolina, P., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Stuart, J., Mose, L. E., Jefferys, S. R., Balu, S., O'Connor, B. D., Chiang, D., Liu, J., Chiang, D. Y., Hayes, D. N., Perou, C. M., Cope, L., Weisenberger, D., Danilova, L., Weisenberger, D. J., Maglinte, D. T., Pan, F., Van Den Berg, D. J., Triche, T., Herman, J. G., Baylin, S. B., Laird, P. W., Noble, M., Gehlenborg, N., DiCara, D., Zhang, J., Wu, C. J., Liu, S. Y., Zou, L., Lin, P., Cho, J., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Sinha, R., Ciriello, G., Cerami, E., Gross, B., Jacobsen, A., Gao, J., Aksoy, B. A., Weinhold, N., Ramirez, R., Taylor, B. S., Antipin, Y., Reva, B., Mo, Q., Seshan, V., Paik, P. K., Akbani, R., Zhang, N., Broom, B. M., Casasent, T., Unruh, A., Wakefield, C., Cason, R. C., Baggerly, K. A., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Ng, S., Goldstein, T., Waltman, P., Sokolov, A., Collisson, E., Ellrott, K., Collisson, E. A., Zerbino, D., Ma, S., Craft, B., Du, Y., Cabanski, C., Walter, V., Marron, J. S., Liu, Y., Wang, K., Prins, J. F., Creighton, C. J., Zhang, Y., Travis, W. D., Rekhtman, N., Yi, J., Aubry, M. C., Cheney, R., Dacic, S., Flieder, D., Funkhouser, W., Illei, P., Myers, J., Tsao, M. S., Penny, R., Mallery, D., Shelton, T., Hatfield, M., Morris, S., Yena, P., Shelton, C., Sherman, M., Paulauskis, J., Govindan, R., Azodo, I., Beer, D., Bose, R., Byers, L. A., Carbone, D., Chang, L. W., Chun, E., Ding, L., Heymach, J., Ida, C., Johnson, B., Jurisica, I., Kaufman, J., Kosari, F., Kwiatkowski, D., Maher, C. A., Pao, W., Peifer, M., Robertson, G., Rusch, V., Siegfried, J., Sougnez, C., Thomas, R. K., Tomaszek, S., Vaske, C., Wheeler, D., Wigle, D. A., Wilks, C., Zhang, J. J., Jensen, M. A., Sfeir, R., Kahn, A. B., Chu, A. L., Kothiyal, P., Wang, Z., Snyder, E. E., Pontius, J., Pihl, T. D., Backus, M., Walton, J., Baboud, J., Berton, D. L., Nicholls, M. C., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P. A., Alonso, S., Sanbhadti, R. N., Barletta, S. P., Greene, J. M., Pot, D. A., Bandarchi-Chamkhaleh, B., Boyd, J., Weaver, J., Azodo, I. A., Tomaszek, S. C., Yang, P., Brock, M. V., Rogers, K., Rutledge, M., Brown, T., Lee, B., Shin, J., Trusty, D., Dhir, R., Siegfried, J. M., Potapova, O., Fedosenko, K. V., Zakowski, M., Nemirovich-Danchenko, E., Iacocca, M. V., Brown, J., Rabeno, B., Czerwinski, C., Petrelli, N., Fan, Z., Todaro, N., Eckman, J., Rathmell, W. K., Thorne, L. B., Huang, M., Boice, L., Hill, A., Curley, E., Morrison, C., Gaudioso, C., Bartlett, J. M. S., Kodeeswaran, S., Zanke, B., Sekhon, H., David, K., Juhl, H., Le, X. V., Kohl, B., Thorp, R., Tien, N. V., Bang, N. V., Sussman, H., Phu, B. D., Hajek, R., Hung, N. P., Khan, K. Z., Muley, T., Mills Shaw, K. R., Sheth, M., Yang, L., Demchok, J. A., Davidsen, T., Buetow, K., Eley, G., Ferguson, M., Dillon, L. A. L., Schaefer, C., Guyer, M. S., Ozenberger, B. A., Palchik, J. D., Peterson, J., Sofia, H. J., Thomson, E., Johnson, B. E. & Shen, R., Sep 27 2012, In: Nature. 489, 7417, p. 519-525 7 p.

    Research output: Contribution to journal › Article › peer-review

    3127 Scopus citations

  • Comprehensive molecular characterization of human colon and rectal cancer

    Muzny, D. M., Bainbridge, M. N., Chang, K., Dinh, H. H., Drummond, J. A., Fowler, G., Kovar, C. L., Lewis, L. R., Morgan, M. B., Newsham, I. F., Reid, J. G., Santibanez, J., Shinbrot, E., Trevino, L. R., Wu, Y. Q., Wang, M., Gunaratne, P., Donehower, L. A., Creighton, C. J., Wheeler, D. A., & 293 othersGibbs, R. A., Lawrence, M. S., Voet, D., Jing, R., Cibulskis, K., Sivachenko, A., Stojanov, P., McKenna, A., Lander, E. S., Gabriel, S., Ding, L., Fulton, R. S., Koboldt, D. C., Wylie, T., Walker, J., Dooling, D. J., Fulton, L., Delehaunty, K. D., Fronick, C. C., Demeter, R., Mardis, E. R., Wilson, R. K., Chu, A., Chun, H. J. E., Mungall, A. J., Pleasance, E., Gordon Robertson, A., Stoll, D., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chuah, E., Coope, R. J. N., Dhalla, N., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Schein, J. E., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R., Zeng, T., Zhao, Y., Jones, S. J. M., Marra, M. A., Bass, A. J., Ramos, A. H., Saksena, G., Cherniack, A. D., Schumacher, S. E., Tabak, B., Carter, S. L., Pho, N. H., Nguyen, H., Onofrio, R. C., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Meyerson, M., Protopopov, A., Hadjipanayis, A., Lee, E., Xi, R., Yang, L., Ren, X., Sathiamoorthy, N., Chen, P. C., Haseley, P., Xiao, Y., Lee, S., Seidman, J., Chin, L., Park, P. J., Kucherlapati, R., Todd Auman, J., Hoadley, K. A., Du, Y., Wilkerson, M. D., Shi, Y., Liquori, C., Meng, S., Li, L., Turman, Y. J., Topal, M. D., Tan, D., Waring, S., Buda, E., Walsh, J., Jones, C. D., Mieczkowski, P. A., Singh, D., Wu, J., Gulabani, A., Dolina, P., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M., Mose, L. E., Jefferys, S. R., Balu, S., O'Connor, B. D., Prins, J. F., Chiang, D. Y., Neil Hayes, D., Perou, C. M., Hinoue, T., Weisenberger, D. J., Maglinte, D. T., Pan, F., Berman, B. P., Van Den Berg, D. J., Shen, H., Triche, T., Baylin, S. B., Laird, P. W., Getz, G., Noble, M., Voat, D., Gehlenborg, N., Dicara, D., Zhang, J., Zhang, H., Wu, C. J., Liu, S. Y., Shukla, S., Zhou, L., Lin, P., Park, R. W., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Thorsson, V., Reynolds, S. M., Bernard, B., Kreisberg, R., Lin, J., Iype, L., Bressler, R., Erkkilä, T., Gundapuneni, M., Liu, Y., Norberg, A., Robinson, T., Yang, D., Zhang, W., Shmulevich, I., De Ronde, J. J., Schultz, N., Cerami, E., Ciriello, G., Goldberg, A. P., Gross, B., Jacobsen, A., Gao, J., Kaczkowski, B., Sinha, R., Arman Aksoy, B., Antipin, Y., Reva, B., Shen, R., Taylor, B. S., Ladanyi, M., Sander, C., Akbani, R., Zhang, N., Broom, B. M., Casasent, T., Unruh, A., Wakefield, C., Hamilton, S. R., Craig Cason, R., Baggerly, K. A., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Zachary Sanborn, J., Vaske, C. J., Zhu, J., Szeto, C., Scott, G. K., Yau, C., Ng, S., Goldstein, T., Ellrott, K., Collisson, E., Cozen, A. E., Zerbino, D., Wilks, C., Craft, B., Spellman, P., Penny, R., Shelton, T., Hatfield, M., Morris, S., Yena, P., Shelton, C., Sherman, M., Paulauskis, J., Gastier-Foster, J. M., Bowen, J., Ramirez, N. C., Black, A., Pyatt, R., Wise, L., White, P., Bertagnolli, M., Brown, J., Chan, T. A., Chu, G. C., Czerwinski, C., Denstman, F., Dhir, R., Dörner, A., Fuchs, C. S., Guillem, J. G., Iacocca, M., Juhl, H., Kaufman, A., Iii, B. K., Van Le, X., Mariano, M. C., Medina, E. N., Meyers, M., Nash, G. M., Paty, P. B., Petrelli, N., Rabeno, B., Richards, W. G., Solit, D., Swanson, P., Temple, L., Tepper, J. E., Thorp, R., Vakiani, E., Weiser, M. R., Willis, J. E., Witkin, G., Zeng, Z., Zinner, M. J., Zornig, C., Jensen, M. A., Sfeir, R., Kahn, A. B., Chu, A. L., Kothiyal, P., Wang, Z., Snyder, E. E., Pontius, J., Pihl, T. D., Ayala, B., Backus, M., Walton, J., Whitmore, J., Baboud, J., Berton, D. L., Nicholls, M. C., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P. A., Alonso, S., Sanbhadti, R. N., Barletta, S. P., Greene, J. M., Pot, D. A., Shaw, K. R. M., Dillon, L. A. L., Buetow, K., Davidsen, T., Demchok, J. A., Eley, G., Ferguson, M., Fielding, P., Schaefer, C., Sheth, M., Yang, L., Guyer, M. S., Ozenberger, B. A., Palchik, J. D., Peterson, J., Sofia, H. J. & Thomson., E., Jul 19 2012, In: Nature. 487, 7407, p. 330-337 8 p.

    Research output: Contribution to journal › Article › peer-review

    6383 Scopus citations

  • Comprehensive molecular portraits of human breast tumours

    Koboldt, D. C., Fulton, R. S., McLellan, M. D., Schmidt, H., Kalicki-Veizer, J., McMichael, J. F., Fulton, L. L., Dooling, D. J., Ding, L., Mardis, E. R., Wilson, R. K., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Carter, C., Chu, A., Chuah, E., Chun, H. J. E., Coope, R. J. N., & 323 othersDhalla, N., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Mungall, A. J., Pleasance, E., Robertson, A. G., Schein, J. E., Shafiei, A., Sipahimalani, P., Slobodan, J. R., Stoll, D., Tam, A., Thiessen, N., Varhol, R. J., Wye, N., Zeng, T., Zhao, Y., Birol, I., Jones, S. J. M., Marra, M. A., Cherniack, A. D., Saksena, G., Onofrio, R. C., Pho, N. H., Carter, S. L., Schumacher, S. E., Tabak, B., Hernandez, B., Gentry, J., Nguyen, H., Crenshaw, A., Ardlie, K., Beroukhim, R., Winckler, W., Getz, G., Gabriel, S. B., Meyerson, M., Chin, L., Kucherlapati, R., Hoadley, K. A., Auman, J. T., Fan, C., Turman, Y. J., Shi, Y., Li, L., Topal, M. D., He, X., Chao, H. H., Prat, A., Silva, G. O., Iglesia, M. D., Zhao, W., Usary, J., Berg, J. S., Adams, M., Booker, J., Wu, J., Gulabani, A., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Mose, L. E., Jefferys, S. R., Balu, S., Parker, J. S., Hayes, D. N., Perou, C. M., Malik, S., Mahurkar, S., Shen, H., Weisenberger, D. J., Triche, T., Lai, P. H., Bootwalla, M. S., Maglinte, D. T., Berman, B. P., Van Den Berg, D. J., Baylin, S. B., Laird, P. W., Creighton, C. J., Donehower, L. A., Noble, M., Voet, D., Gehlenborg, N., Di Cara, D., Zhang, J., Zhang, H., Wu, C. J., Yingchun Liu, S., Lawrence, M. S., Zou, L., Sivachenko, A., Lin, P., Stojanov, P., Jing, R., Cho, J., Sinha, R., Park, R. W., Nazaire, M. D., Robinson, J., Thorvaldsdottir, H., Mesirov, J., Park, P. J., Reynolds, S., Kreisberg, R. B., Bernard, B., Bressler, R., Erkkila, T., Lin, J., Thorsson, V., Zhang, W., Shmulevich, I., Ciriello, G., Weinhold, N., Schultz, N., Gao, J., Cerami, E., Gross, B., Jacobsen, A., Sinha, R., Aksoy, B. A., Antipin, Y., Reva, B., Shen, R., Taylor, B. S., Ladanyi, M., Sander, C., Anur, P., Spellman, P. T., Lu, Y., Liu, W., Verhaak, R. R. G., Mills, G. B., Akbani, R., Zhang, N., Broom, B. M., Casasent, T. D., Wakefield, C., Unruh, A. K., Baggerly, K., Coombes, K., Weinstein, J. N., Haussler, D., Benz, C. C., Stuart, J. M., Benz, S. C., Zhu, J., Szeto, C. C., Scott, G. K., Yau, C., Paull, E. O., Carlin, D., Wong, C., Sokolov, A., Thusberg, J., Mooney, S., Ng, S., Goldstein, T. C., Ellrott, K., Grifford, M., Wilks, C., Ma, S., Craft, B., Yan, C., Hu, Y., Meerzaman, D., Gastier-Foster, J. M., Bowen, J., Ramirez, N. C., Black, A. D., Pyatt, R. E., White, P., Zmuda, E. J., Frick, J., Lichtenberg, T. M., Brookens, R., George, M. M., Gerken, M. A., Harper, H. A., Leraas, K. M., Wise, L. J., Tabler, T. R., McAllister, C., Barr, T., Hart-Kothari, M., Tarvin, K., Saller, C., Sandusky, G., Mitchell, C., Iacocca, M. V., Brown, J., Rabeno, B., Czerwinski, C., Petrelli, N., Dolzhansky, O., Abramov, M., Voronina, O., Potapova, O., Marks, J. R., Suchorska, W. M., Murawa, D., Kycler, W., Ibbs, M., Korski, K., Spychała, A., Murawa, P., Brzeziński, J. J., Perz, H., Łaźniak, R., Teresiak, M., Tatka, H., Leporowska, E., Bogusz-Czerniewicz, M., Malicki, J., Mackiewicz, A., Wiznerowicz, M., Van Le, X., Kohl, B., Viet Tien, N., Thorp, R., Van Bang, N., Sussman, H., Phu, B. D., Hajek, R., Hung, N. P., Phuong, T. V. T., Thang, H. Q., Khan, K. Z., Penny, R., Mallery, D., Curley, E., Shelton, C., Yena, P., Ingle, J. N., Couch, F. J., Lingle, W. L., King, T. A., Gonzalez-Angulo, A. M., Dyer, M. D., Liu, S., Meng, X., Patangan, M., Waldman, F., Stöppler, H., Rathmell, W. K., Thorne, L., Huang, M., Boice, L., Hill, A., Morrison, C., Gaudioso, C., Bshara, W., Daily, K., Egea, S. C., Pegram, M. D., Gomez-Fernandez, C., Dhir, R., Bhargava, R., Brufsky, A., Shriver, C. D., Hooke, J. A., Campbell, J. L., Mural, R. J., Hu, H., Somiari, S., Larson, C., Deyarmin, B., Kvecher, L., Kovatich, A. J., Ellis, M. J., Stricker, T., White, K., Olopade, O., Luo, C., Chen, Y., Bose, R., Chang, L. W., Beck, A. H., Pihl, T., Jensen, M., Sfeir, R., Kahn, A., Chu, A., Kothiyal, P., Wang, Z., Snyder, E., Pontius, J., Ayala, B., Backus, M., Walton, J., Baboud, J., Berton, D., Nicholls, M., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P., Alonso, S., Sanbhadti, R., Barletta, S., Pot, D., Sheth, M., Demchok, J. A., Shaw, K. R. M., Yang, L., Eley, G., Ferguson, M. L., Tarnuzzer, R. W., Zhang, J., Dillon, L. A. L., Buetow, K., Fielding, P., Ozenberger, B. A., Guyer, M. S., Sofia, H. J. & Palchik, J. D., Oct 4 2012, In: Nature. 490, 7418, p. 61-70 10 p.

    Research output: Contribution to journal › Article › peer-review

    8965 Scopus citations

  • Crystal structure of a major seed storage protein, 11S proglobulin, from Amaranthus hypochondriacus: Insight into its physico-chemical properties

    Tandang-Silvas, M. R., Cabanos, C. S., Carrazco Peña, L. D., De La Rosa, A. P. B., Osuna-Castro, J. A., Utsumi, S., Mikami, B. & Maruyama, N., Nov 15 2012, In: Food Chemistry. 135, 2, p. 819-826 8 p.

    Research output: Contribution to journal › Article › peer-review

    32 Scopus citations

  • Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

    Jang, Y. C., Liu, Y., Hayworth, C. R., Bhattacharya, A., Lustgarten, M. S., Muller, F. L., Chaudhuri, A., Qi, W., Li, Y., Huang, J. Y., Verdin, E., Richardson, A. & Van Remmen, H., Oct 2012, In: Aging Cell. 11, 5, p. 770-782 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    75 Scopus citations

  • Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS

    Bhattacharya, A., Bokov, A., Muller, F. L., Jernigan, A. L., Maslin, K., Diaz, V., Richardson, A. & Van Remmen, H., Aug 2012, In: Neurobiology of Aging. 33, 8, p. 1829-1832 4 p.

    Research output: Contribution to journal › Article › peer-review

    51 Scopus citations

  • Emerging insights into the molecular and cellular basis of glioblastoma

    Dunn, G. P., Rinne, M. L., Wykosky, J., Genovese, G., Quayle, S. N., Dunn, I. F., Agarwalla, P. K., Chheda, M. G., Campos, B., Wang, A., Brennan, C., Ligon, K. L., Furnari, F., Cavene, W. K., Depinho, R. A., Chin, L. & Hah, W. C., 2012, In: Genes and Development. 26, 8, p. 756-784 29 p.

    Research output: Contribution to journal › Article › peer-review

    445 Scopus citations

  • Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells

    Kumar, A., Xu, J., Sung, B., Kumar, S., Yu, D., Aggarwal, B. B. & Mehta, K., Jan 6 2012, In: Breast Cancer Research. 14, 1, R4.

    Research output: Contribution to journal › Article › peer-review

    51 Scopus citations

  • H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence

    Chicas, A., Kapoor, A., Wang, X., Aksoy, O., Evertts, A. G., Zhang, M. Q., Garcia, B. A., Bernstein, E. & Lowe, S. W., Jun 5 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 8971-8976 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    125 Scopus citations

  • Heavy-ion beam irradiation is an effective technique for reducing major allergens in peanut seeds

    Cabanos, C. S., Katayama, H., Urabe, H., Kuwata, C., Murota, Y., Abe, T., Okumoto, Y. & Maruyama, N., Aug 2012, In: Molecular Breeding. 30, 2, p. 1037-1044 8 p.

    Research output: Contribution to journal › Article › peer-review

    7 Scopus citations

  • Improved antibiotic-impregnated catheters with extended-spectrum activity against resistant bacteria and fungi

    Raad, I., Mohamed, J. A., Reitzel, R. A., Jiang, Y., Raad, S., Al Shuaibi, M., Chaftari, A. M. & Hachem, R. Y., Feb 2012, In: Antimicrobial agents and chemotherapy. 56, 2, p. 935-941 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    66 Scopus citations

  • Integrative functional genomics identifies RINT1 as a novel GBM oncogene

    Quayle, S. N., Chheda, M. G., Shukla, S. A., Wiedemeyer, R., Tamayo, P., Dewan, R. W., Zhuang, L., Huang-Hobbs, E., Haidar, S., Xiao, Y., Ligon, K. L., Hahn, W. C. & Chin, L., Nov 2012, In: Neuro-oncology. 14, 11, p. 1325-1331 7 p.

    Research output: Contribution to journal › Article › peer-review

    13 Scopus citations

  • Melanoma genome sequencing reveals frequent PREX2 mutations

    Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., Zhang, H., Zeid, R., Ren, X., Cibulskis, K., Sivachenko, A. Y., Wagle, N., Sucker, A., Sougnez, C., Onofrio, R., Ambrogio, L., & 28 othersAuclair, D., Fennell, T., Carter, S. L., Drier, Y., Stojanov, P., Singer, M. A., Voet, D., Jing, R., Saksena, G., Barretina, J., Ramos, A. H., Pugh, T. J., Stransky, N., Parkin, M., Winckler, W., Mahan, S., Ardlie, K., Baldwin, J., Wargo, J., Schadendorf, D., Meyerson, M., Gabriel, S. B., Golub, T. R., Wagner, S. N., Lander, E. S., Getz, G., Chin, L. & Garraway, L. A., May 24 2012, In: Nature. 485, 7399, p. 502-506 5 p.

    Research output: Contribution to journal › Article › peer-review

    588 Scopus citations

  • microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma

    Genovese, G., Ergun, A., Shukla, S. A., Campos, B., Hanna, J., Ghosh, P., Quayle, S. N., Rai, K., Colla, S., Ying, H., Wu, C. J., Sarkar, S., Xiao, Y., Zhang, J., Zhang, H., Kwong, L., Dunn, K., Wiedemeyer, W. R., Brennan, C., Zheng, H., & 3 othersRimm, D. L., Collins, J. J. & Chin, L., Aug 2012, In: Cancer discovery. 2, 8, p. 736-749 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    96 Scopus citations

  • Nanosponge-encapsulated camptothecin exerts anti-tumor activity in human prostate cancer cells

    Minelli, R., Cavalli, R., Ellis, L., Pettazzoni, P., Trotta, F., Ciamporcero, E., Barrera, G., Fantozzi, R., Dianzani, C. & Pili, R., Nov 20 2012, In: European Journal of Pharmaceutical Sciences. 47, 4, p. 686-694 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    70 Scopus citations

  • Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

    Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., Yan, H., Wang, W., Chen, S., Viale, A., Zheng, H., Paik, J. H., Lim, C., Guimaraes, A. R., Martin, E. S., Chang, J., & 11 othersHezel, A. F., Perry, S. R., Hu, J., Gan, B., Xiao, Y., Asara, J. M., Weissleder, R., Wang, Y. A., Chin, L., Cantley, L. C. & Depinho, R. A., Apr 27 2012, In: Cell. 149, 3, p. 656-670 15 p.

    Research output: Contribution to journal › Article › peer-review

    1458 Scopus citations

  • Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma

    Kwong, L. N., Costello, J. C., Liu, H., Jiang, S., Helms, T. L., Langsdorf, A. E., Jakubosky, D., Genovese, G., Muller, F. L., Jeong, J. H., Bender, R. P., Chu, G. C., Flaherty, K. T., Wargo, J. A., Collins, J. J. & Chin, L., Oct 2012, In: Nature medicine. 18, 10, p. 1503-1510 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    293 Scopus citations

  • Passenger deletions generate therapeutic vulnerabilities in cancer

    Muller, F. L., Colla, S., Aquilanti, E., Manzo, V. E., Genovese, G., Lee, J., Eisenson, D., Narurkar, R., Deng, P., Nezi, L., Lee, M. A., Hu, B., Hu, J., Sahin, E., Ong, D., Fletcher-Sananikone, E., Ho, D., Kwong, L., Brennan, C., Wang, Y. A., & 2 othersChin, L. & Depinho, R. A., Aug 16 2012, In: Nature. 488, 7411, p. 337-342 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    251 Scopus citations

  • PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

    Izaguirre, D. I., Zhu, W., Hai, T., Cheung, H. C., Krahe, R. & Cote, G. J., Nov 2012, In: Molecular Carcinogenesis. 51, 11, p. 895-906 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    67 Scopus citations

  • Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores

    Mariani, L., Chiroli, E., Nezi, L., Muller, H., Piatti, S., Musacchio, A. & Ciliberto, A., Oct 23 2012, In: Current Biology. 22, 20, p. 1900-1908 9 p.

    Research output: Contribution to journal › Article › peer-review

    25 Scopus citations

  • Rosiglitazone and AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells

    Cerbone, A., Toaldo, C., Minelli, R., Ciamporcero, E., Pizzimenti, S., Pettazzoni, P., Roma, G., Dianzani, M. U., Ullio, C., Ferretti, C., Dianzani, C. & Barrera, G., Jun 28 2012, In: PloS one. 7, 6, e40149.

    Research output: Contribution to journal › Article › peer-review

    26 Scopus citations

  • Somatic Mutations of PIK3R1 Promote Gliomagenesis

    Quayle, S. N., Lee, J. Y., Cheung, L. W. T., Ding, L., Wiedemeyer, R., Dewan, R. W., Huang-Hobbs, E., Zhuang, L., Wilson, R. K., Ligon, K. L., Mills, G. B., Cantley, L. C. & Chin, L., Nov 14 2012, In: PloS one. 7, 11, e49466.

    Research output: Contribution to journal › Article › peer-review

    46 Scopus citations

  • Spectrum of somatic mitochondrial mutations in five cancers

    Larman, T. C., DePalma, S. R., Hadjipanayis, A. G., Protopopov, A., Zhang, J., Gabriel, S. B., Chin, L., Seidman, C. E., Kucherlapati, R. & Seidman, J. G., Aug 28 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 35, p. 14087-14091 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    180 Scopus citations

  • Spontaneous cell fusion of acute leukemia cells and macrophages observed in cells with leukemic potential

    Martin-Padura, I., Marighetti, P., Gregato, G., Agliano, A., Malazzi, O., Mancuso, P., Pruneri, G., Viale, A. & Bertolini, F., Nov 2012, In: Neoplasia (United States). 14, 11, p. 1057-1066 10 p.

    Research output: Contribution to journal › Article › peer-review

    24 Scopus citations

  • STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA

    Chen, A. J., Paik, J. H., Zhang, H., Shukla, S. A., Mortensen, R., Hu, J., Ying, H., Hu, B., Hurt, J., Farny, N., Dong, C., Xiao, Y., Wang, Y. A., Silver, P. A., Chin, L., Vasudevan, S. & Depinho, R. A., 2012, In: Genes and Development. 26, 13, p. 1459-1472 14 p.

    Research output: Contribution to journal › Article › peer-review

    94 Scopus citations

  • TAp63 is a master transcriptional regulator of lipid and glucose metabolism

    Su, X., Gi, Y. J., Chakravarti, D., Chan, I. L., Zhang, A., Xia, X., Tsai, K. Y. & Flores, E. R., Oct 3 2012, In: Cell Metabolism. 16, 4, p. 511-525 15 p.

    Research output: Contribution to journal › Article › peer-review

    95 Scopus citations

  • TARGETgene: A Tool for Identification of Potential Therapeutic Targets in Cancer

    Wu, C. C., D'Argenio, D., Asgharzadeh, S. & Triche, T., Aug 31 2012, In: PloS one. 7, 8, e43305.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations

  • Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases

    Ding, Z., Wu, C. J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A., Chu, G. C., Wang, G., Lu, X., Labrot, E. S., Hu, J., Wang, W., Xiao, Y., Zhang, H., Zhang, J., Zhang, J., Gan, B., Perry, S. R., Jiang, S., Li, L., & 4 othersHorner, J. W., Wang, Y. A., Chin, L. & Depinho, R. A., Mar 2 2012, In: Cell. 148, 5, p. 896-907 12 p.

    Research output: Contribution to journal › Article › peer-review

    179 Scopus citations

  • Temporal control of neural crest lineage generation by wnt/β-catenin signaling

    Hari, L., Miescher, I., Shakhova, O., Suter, U., Chin, L., Taketo, M., Richardson, W. D., Kessaris, N. & Sommer, L., Jun 15 2012, In: Development (Cambridge). 139, 12, p. 2107-2117 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    107 Scopus citations

  • TGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway

    Sánchez, N. S. & Barnett, J. V., Feb 2012, In: Cellular Signalling. 24, 2, p. 539-548 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    52 Scopus citations

  • The ω-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function

    Johnson, T. A. & Holyoak, T., Nov 27 2012, In: Biochemistry. 51, 47, p. 9547-9559 13 p.

    Research output: Contribution to journal › Article › peer-review

    27 Scopus citations

  • Tissue Transglutaminase Constitutively Activates HIF-1α Promoter and Nuclear Factor-κB via a Non-Canonical Pathway

    Kumar, S. & Mehta, K., Nov 19 2012, In: PloS one. 7, 11, e49321.

    Research output: Contribution to journal › Article › peer-review

    74 Scopus citations

  • ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

    Ahn, Y. H., Gibbons, D. L., Chakravarti, D., Creighton, C. J., Rizvi, Z. H., Adams, H. P., Pertsemlidis, A., Gregory, P. A., Wright, J. A., Goodall, G. J., Flores, E. R. & Kurie, J. M., Sep 4 2012, In: Journal of Clinical Investigation. 122, 9, p. 3170-3183 14 p.

    Research output: Contribution to journal › Article › peer-review

    136 Scopus citations