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  • 2014

    The somatic genomic landscape of chromophobe renal cell carcinoma

    The Cancer Genome Atlas Research Network, 2014, In: Cancer cell. 26, 3, p. 319-330 12 p.

    Research output: Contribution to journal › Article › peer-review

    582 Scopus citations

  • Tissue transglutaminase expression promotes castration-resistant phenotype and transcriptional repression of androgen receptor

    Han, A. L., Kumar, S., Fok, J. Y., Tyagi, A. K. & Mehta, K., Jun 2014, In: European Journal of Cancer. 50, 9, p. 1685-1696 12 p.

    Research output: Contribution to journal › Article › peer-review

    23 Scopus citations

  • Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways

    Kumar, S., Donti, T. R., Agnihotri, N. & Mehta, K., Jun 15 2014, In: International journal of cancer. 134, 12, p. 2798-2807 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    45 Scopus citations

  • Twist2 contributes to cisplatin-resistance of ovarian cancer through the AKT/GSK-3β signaling pathway

    Wang, T., Li, Y., Tuerhanjiang, A., Wang, W., Wu, Z., Yuan, M., Maitituoheti, M. & Wang, S., Apr 2014, In: Oncology Letters. 7, 4, p. 1102-1108 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    16 Scopus citations

  • Yap1 activation enables bypass of oncogenic KRAS addiction in pancreatic cancer

    Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C. J., Sadanandam, A., Hu, B., Chang, Q., Chu, G. C., Al-Khalil, R., Jiang, S., Xia, H., Fletcher-Sananikone, E., Lim, C., Horwitz, G. I., Viale, A., Pettazzoni, P., & 10 othersSanchez, N., Wang, H., Protopopov, A., Zhang, J., Heffernan, T., Johnson, R. L., Chin, L., Wang, Y. A., Draetta, G. & Depinho, R. A., Jul 3 2014, In: Cell. 158, 1, p. 185-197 13 p.

    Research output: Contribution to journal › Article › peer-review

    515 Scopus citations
  • 2013

    A Comprehensive Nuclear Receptor Network for Breast Cancer Cells

    Kittler, R., Zhou, J., Hua, S., Ma, L., Liu, Y., Pendleton, E., Cheng, C., Gerstein, M. & White, K. P., 2013, In: Cell Reports. 3, 2, p. 538-551 14 p.

    Research output: Contribution to journal › Article › peer-review

    63 Scopus citations

  • A non-redundant function of cyclin E1 in hematopoietic stem cells

    Campaner, S., Viale, A., De Fazio, S., Doni, M., De Franco, F., D'Artista, L., Sardella, D., Pelicci, P. G. & Amati, B., Dec 1 2013, In: Cell Cycle. 12, 23, p. 3663-3672 10 p.

    Research output: Contribution to journal › Article › peer-review

    9 Scopus citations

  • Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function

    Voo, K. S., Bover, L., Harline, M. L., Vien, L. T., Facchinetti, V., Arima, K., Kwak, L. W. & Liu, Y. J., Oct 1 2013, In: Journal of Immunology. 191, 7, p. 3641-3650 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    81 Scopus citations

  • A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis

    Mancinelli, L., Secca, T., De Angelis, P. M., Mancini, F., Marchesini, M., Marinelli, C., Barberini, L. & Grignani, F., Aug 6 2013, In: Cell Division. 8, 1, 11.

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • Association of an oestrogen receptor gene polymorphism in Chinese Han women with endometriosis and endometriosis-related infertility

    Wang, W., Li, Y., Maitituoheti, M., Yang, R., Wu, Z., Wang, T., Ma, D. & Wang, S., Jan 2013, In: Reproductive BioMedicine Online. 26, 1, p. 93-98 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    23 Scopus citations

  • A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival

    Zheng, S., Fu, J., Vegesna, R., Mao, Y., Heathcock, L. E., Torres-Garcia, W., Ezhilarasan, R., Wang, S., McKenna, A., Chin, L., Brennan, C. W., Alfred Yung, W. K., Weinstein, J. N., Aldape, K. D., Sulman, E. P., Chen, K., Koul, D. & Verhaak, R. G. W., Jul 1 2013, In: Genes and Development. 27, 13, p. 1462-1472 11 p.

    Research output: Contribution to journal › Article › peer-review

    61 Scopus citations

  • A systems biology approach to personalizing therapeutic combinations

    Kwong, L. N., Heffernan, T. P. & Chin, L., Dec 2013, In: Cancer discovery. 3, 12, p. 1339-1344 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling

    Vin, H., Ojeda, S. S., Ching, G., Leung, M. L., Chitsazzadeh, V., Dwyer, D. W., Adelmann, C. H., Restrepo, M., Richards, K. N., Stewart, L. R., Du, L., Ferguson, S. B., Chakravarti, D., Ehrenreiter, K., Baccarini, M., Ruggieri, R., Curry, J. L., Kim, K. B., Ciurea, A. M., Duvic, M., & 5 othersPrieto, V. G., Ullrich, S. E., Dalby, K. N., Flores, E. R. & Tsai, K. Y., Nov 5 2013, In: eLife. 2013, 2, e00969.

    Research output: Contribution to journal › Article › peer-review

    58 Scopus citations

  • Comprehensivemolecular characterization of clear cell renal cell carcinoma

    Creighton, C. J., Morgan, M., Gunaratne, P. H., Wheeler, D. A., Gibbs, R. A., Robertson, G., Chu, A., Beroukhim, R., Cibulskis, K., Signoretti, S., Vandin, F., Wu, H. T., Raphael, B. J., Verhaak, R. G. W., Tamboli, P., Torres-Garcia, W., Akbani, R., Weinstein, J. N., Reuter, V., Hsieh, J. J., & 268 othersBrannon, A. R., Hakimi, A. A., Jacobsen, A., Ciriello, G., Reva, B., Ricketts, C. J., Linehan, W. M., Stuart, J. M., Rathmell, W. K., Hui, S., Laird, P. W., Muzny, D., Davis, C., Liu, X., Chang, K., Kakkar, N., Treviño, L. R., Benton, S., Reid, J. G., Morton, D., Doddapaneni, H., Yi, H., Lewis, L., Huyen, D., Kovar, C., Zhu, Y., Santibanez, J., Min, W., Hale, W., Kalra, D., Getz, G., Lawrence, M. S., Sougnez, C., Carter, S. L., Sivachenko, A., Lee, L., Stewart, C., Voet, D., Fisher, S., Gabriel, S. B., Lander, E., Schumacher, S. E., Tabak, B., Saksena, G., Onofrio, R. C., Cherniack, A. D., Gentry, J., Ardlie, K., Meyerson, M., Chun, H. J. E., Mungall, A. J., Sipahimalani, P., Stoll, D., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Carlsen, R., Carter, C., Chuah, E., Coope, R. J. N., Dhalla, N., Gorski, S., Guin, R., Hirst, C., Hirst, M., Holt, R. A., Lebovitz, C., Lee, D., Li, H. I., Mayo, M., Moore, R. A., Pleasance, E., Plettner, P., Schein, J. E., Shafiei, A., Slobodan, J. R., Tam, A., Thiessen, N., Varhol, R. J., Wye, N., Zhao, Y., Birol, I., Jones, S. J. M., Marra, M. A., Auman, J. T., Tan, D., Jones, C. D., Hoadley, K. A., Mieczkowski, P. A., Mose, L. E., Jefferys, S. R., Topal, M. D., Liquori, C., Turman, Y. J., Yan, S., Waring, S., Buda, E., Walsh, J., Wu, J., Bodenheimer, T., Hoyle, A. P., Simons, J. V., Soloway, M. G., Balu, S., Parker, J. S., Hayes, D. N., Perou, C. M., Kucherlapati, R., Park, P., Triche, T., Weisenberger, D. J., Lai, P. H., Bootwalla, M. S., Maglinte, D. T., Mahurkar, S., Berman, B. P., Van Den Berg, D. J., Cope, L., Baylin, S. B., Noble, M. S., DiCara, D., Zhang, H., Cho, J., Heiman, D. I., Gehlenborg, N., Mallard, W., Pei, L., Frazer, S., Stojanov, P., Liu, Y., Zhou, L., Kim, J., Chin, L., Benz, C., Yau, C., Reynolds, S. M., Shmulevich, I., Vegesna, R., Kim, H., Wei, Z., Cogdell, D., Jonasch, E., Ding, Z., Lu, Y., Zhang, N., Unruh, A. K., Casasent, T. D., Wakefield, C., Tsavachidou, D., Mills, G. B., Gao, J., Cerami, E., Gross, B., Aksoy, B. A., Sinha, R., Weinhold, N., Sumer, S. O., Taylor, B. S., Shen, R., Ostrovnaya, I., Berger, M. F., Ladanyi, M., Sander, C., Fei, S. S., Stout, A., Spellman, P. T., Rubin, D. L., Liu, T. T., Sam, N., Paull, E. O., Carlin, D., Goldstein, T., Waltman, P., Ellrott, K., Jing, Z., Haussler, D., Xiao, W., Shelton, C., Gardner, J., Penny, R., Sherman, M., Mallery, D., Morris, S., Paulauskis, J., Burnett, K., Shelton, T., Kaelin, W. G., Choueiri, T., Atkins, M. B., Curley, E., Tickoo, S., Thorne, L., Boice, L., Mei, H., Fisher, J. C., Vocke, C. D., Peterson, J., Worrell, R., Merino, M. J., Schmidt, L. S., Czerniak, B. A., Aldape, K. D., Wood, C. G., Boyd, J., Weaver, J. E., Iacocca, M. V., Petrelli, N., Witkin, G., Brown, J., Czerwinski, C., Huelsenbeck-Dill, L., Rabeno, B., Myers, J., Morrison, C., Bergsten, J., Eckman, J., Harr, J., Smith, C., Tucker, K., Zach, L. A., Bshara, W., Gaudioso, C., Dhir, R., Maranchie, J., Nelson, J., Parwani, A., Potapova, C. O., Fedosenko, K., Cheville, J. C., Thompson, R. H., Mosquera, J. M., Rubin, M. A., Blute, M. L., Pihl, T., Jensen, M., Sfeir, R., Kahn, A., Chu, A., Kothiyal, P., Snyder, E., Pontius, J., Ayala, B., Backus, M., Walton, J., Baboud, J., Berton, D., Nicholls, M., Srinivasan, D., Raman, R., Girshik, S., Kigonya, P., Alonso, S., Sanbhadti, R., Barletta, S., Pot, D., Sheth, M., Demchok, J. A., Davidsen, T., Wang, Z., Yang, L., Tarnuzzer, R. W., Zhang, J., Eley, G., Ferguson, M. L., Mills Shaw, K. R., Guyer, M. S., Ozenberger, B. A. & Sofia, H. J., 2013, In: Nature. 499, 7456, p. 43-49 7 p.

    Research output: Contribution to journal › Article › peer-review

    2523 Scopus citations

  • Diverse mechanisms of somatic structural variations in human cancer genomes

    Yang, L., Luquette, L. J., Gehlenborg, N., Xi, R., Haseley, P. S., Hsieh, C. H., Zhang, C., Ren, X., Protopopov, A., Chin, L., Kucherlapati, R., Lee, C. & Park, P. J., May 9 2013, In: Cell. 153, 4, p. 919-929 11 p.

    Research output: Contribution to journal › Article › peer-review

    245 Scopus citations

  • Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons

    Sanborn, J. Z., Salama, S. R., Grifford, M., Brennan, C. W., Mikkelsen, T., Jhanwar, S., Katzman, S., Chin, L. & Haussler, D., Oct 1 2013, In: Cancer Research. 73, 19, p. 6036-6045 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    78 Scopus citations

  • EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis

    Talasila, K. M., Soentgerath, A., Euskirchen, P., Rosland, G. V., Wang, J., Huszthy, P. C., Prestegarden, L., Skaftnesmo, K. O., Sakariassen, P. Ø., Eskilsson, E., Stieber, D., Keunen, O., Brekka, N., Moen, I., Nigro, J. M., Vintermyr, O. K., Lund-Johansen, M., Niclou, S., Mørk, S. J., Enger, P. Ø., & 2 othersBjerkvig, R. & Miletic, H., May 2013, In: Acta neuropathologica. 125, 5, p. 683-698 16 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    109 Scopus citations

  • Eukaryotic Translation Elongation Factor 1-Alpha 1 Inhibits p53 and p73 Dependent Apoptosis and Chemotherapy Sensitivity

    Blanch, A., Robinson, F., Watson, I. R., Cheng, L. S. & Irwin, M. S., Jun 14 2013, In: PloS one. 8, 6, e66436.

    Research output: Contribution to journal › Article › peer-review

    58 Scopus citations

  • FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

    Yeo, H., Lyssiotis, C. A., Zhang, Y., Ying, H., Asara, J. M., Cantley, L. C. & Paik, J. H., Oct 2 2013, In: EMBO Journal. 32, 19, p. 2589-2602 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    117 Scopus citations

  • Genome-wide mutational signatures of aristolochic acid and its application as a screening tool

    Poon, S. L., Pang, S. T., McPherson, J. R., Yu, W., Huang, K. K., Guan, P., Weng, W. H., Siew, E. Y., Liu, Y., Heng, H. L., Chong, S. C., Gan, A., Tay, S. T., Lim, W. K., Cutcutache, I., Huang, D., Ler, L. D., Nairismägi, M. L., Lee, M. H., Chang, Y. H., & 17 othersYu, K. J., Chan-On, W., Li, B. K., Yuan, Y. F., Qian, C. N., Ng, K. F., Wu, C. F., Hsu, C. L., Bunte, R. M., Stratton, M. R., Andrew Futreal, P., Sung, W. K., Chuang, C. K., Ong, C. K., Rozen, S. G., Tan, P. & Teh, B. T., Aug 7 2013, In: Science translational medicine. 5, 197, 197ra101.

    Research output: Contribution to journal › Article › peer-review

    230 Scopus citations

  • Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

    Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., Kang, YA., Fleming, J. B., Bardeesy, N., Asara, J. M., Haigis, M. C., Depinho, R. A., Cantley, L. C. & Kimmelman, A. C., Apr 4 2013, In: Nature. 496, 7443, p. 101-105 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1462 Scopus citations

  • HIF isoforms in the skin differentially regulate systemic arterial pressure

    Cowburn, A. S., Takeda, N., Boutin, A. T., Kim, J. W., Sterling, J. C., Nakasaki, M., Southwood, M., Goldrath, A. W., Jamora, C., Nizet, V., Chilvers, E. R. & Johnson, R. S., Oct 22 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 43, p. 17570-17575 6 p.

    Research output: Contribution to journal › Article › peer-review

    55 Scopus citations

  • High-level production of lactostatin, a hypocholesterolemic peptide, in transgenic rice using soybean A1aB1b as carrier

    Cabanos, C., Ekyo, A., Amari, Y., Kato, N., Kuroda, M., Nagaoka, S., Takaiwa, F., Utsumi, S. & Maruyama, N., Jun 2013, In: Transgenic Research. 22, 3, p. 621-629 9 p.

    Research output: Contribution to journal › Article › peer-review

    29 Scopus citations

  • Highly recurrent TERT promoter mutations in human melanoma

    Huang, F. W., Hodis, E., Xu, M. J., Kryukov, G. V., Chin, L. & Garraway, L. A., Feb 22 2013, In: Science. 339, 6122, p. 957-959 3 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1430 Scopus citations

  • Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

    Storti, P., Bolzoni, M., Donofrio, G., Airoldi, I., Guasco, D., Toscani, D., Martella, E., Lazzaretti, M., Mancini, C., Agnelli, L., Patrene, K., Maïga, S., Franceschi, V., Colla, S., Anderson, J., Neri, A., Amiot, M., Aversa, F., David Roodman, G. & Giuliani, N., Aug 2013, In: Leukemia. 27, 8, p. 1697-1706 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    93 Scopus citations

  • Identification of cancer fusion drivers using network fusion centrality.

    Wu, C. C., Kannan, K., Lin, S., Yen, L. & Milosavljevic, A., May 1 2013, In: Unknown Journal. 29, 9, p. 1174-1181 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [131I] analogue as useful PET tracers for PI3-kinase

    Sun, D., Bhanu Prasad, B. A., Schuber, P. T., Peng, Z., Maxwell, D. S., Martin, D. V., Guo, L., Han, D., Kurihara, H., Yang, D. J., Gelovani, J. G., Powis, G. & Bornmann, W. G., Sep 1 2013, In: Bioorganic and Medicinal Chemistry. 21, 17, p. 5182-5187 6 p.

    Research output: Contribution to journal › Article › peer-review

    4 Scopus citations

  • Inferring tumour purity and stromal and immune cell admixture from expression data

    Yoshihara, K., Shahmoradgoli, M., Martínez, E., Vegesna, R., Kim, H., Torres-Garcia, W., Treviño, V., Shen, H., Laird, P. W., Levine, D. A., Carter, S. L., Getz, G., Stemke-Hale, K., Mills, G. B. & Verhaak, R. G. W., 2013, In: Nature communications. 4, 2612.

    Research output: Contribution to journal › Article › peer-review

    5091 Scopus citations

  • Inhibition of melanoma development in the Nras(Q61K):: Ink4a-/ mouse model by the small molecule BI-69A11

    Feng, Y., Lau, E., Scortegagna, M., Ruller, C., De, S. K., Barile, E., Krajewski, S., Aza-Blanc, P., Williams, R., Pinkerton, A. B., Jackson, M., Chin, L., Pellecchia, M., Bosenberg, M. & Ronai, Z. A., Jan 2013, In: Pigment Cell and Melanoma Research. 26, 1, p. 136-142 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Integrated genomic characterization of endometrial carcinoma

    Getz, G., Gabriel, S. B., Cibulskis, K., Lander, E., Sivachenko, A., Sougnez, C., Lawrence, M., Kandoth, C., Dooling, D., Fulton, R., Fulton, L., Kalicki-Veizer, J., McLellan, M. D., O'Laughlin, M., Schmidt, H., Wilson, R. K., Ye, K., Li, D., Ally, A., Balasundaram, M., & 256 othersBirol, I., Butterfield, Y. S. N., Carlsen, R., Carter, C., Chu, A., Chuah, E., Chun, H. J. E., Dhalla, N., Guin, R., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Plettner, P., Schein, J. E., Sipahimalani, P., Tam, A., Varhol, R. J., Gordon Robertson, A., Cherniack, A. D., Pashtan, I., Saksena, G., Onofrio, R. C., Schumacher, S. E., Tabak, B., Carter, S. L., Hernandez, B., Gentry, J., Salvesen, H. B., Ardlie, K., Winckler, W., Beroukhim, R., Meyerson, M., Hadjipanayis, A., Lee, S., Mahadeshwar, H. S., Park, P., Protopopov, A., Ren, X., Seth, S., Song, X., Tang, J., Xi, R., Yang, L., Dong, Z., Kucherlapati, R., Chin, L., Zhang, J., Todd Auman, J., Balu, S., Bodenheimer, T., Buda, E., Neil Hayes, D., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Parker, J. S., Perou, C. M., Roach, J., Yan, S., Simons, J. V., Soloway, M. G., Tan, D., Topal, M. D., Waring, S., Wu, J., Hoadley, K. A., Baylin, S. B., Bootwalla, M. S., Lai, P. H., Triche, T. J., Van Den Berg, D. J., Weisenberger, D. J., Laird, P. W., Shen, H., Cho, J., Dicara, D., Frazer, S., Heiman, D., Jing, R., Lin, P., Mallard, W., Stojanov, P., Voet, D., Zhang, H., Zou, L., Noble, M., Reynolds, S. M., Shmulevich, I., Arman Aksoy, B., Antipin, Y., Ciriello, G., Dresdner, G., Gao, J., Gross, B., Jacobsen, A., Ladanyi, M., Reva, B., Sander, C., Sinha, R., Onur Sumer, S., Taylor, B. S., Cerami, E., Weinhold, N., Schultz, N., Shen, R., Benz, S., Goldstein, T., Haussler, D., Ng, S., Szeto, C., Stuart, J., Benz, C. C., Yau, C., Zhang, W., Annala, M., Broom, B. M., Casasent, T. D., Ju, Z., Liang, H., Liu, G., Lu, Y., Unruh, A. K., Wakefield, C., Weinstein, J. N., Zhang, N., Liu, Y., Broaddus, R., Akbani, R., Mills, G. B., Adams, C., Barr, T., Black, A. D., Bowen, J., Deardurff, J., Frick, J., Gastier-Foster, J. M., Grossman, T., Harper, H. A., Hart-Kothari, M., Helsel, C., Hobensack, A., Kuck, H., Kneile, K., Leraas, K. M., Lichtenberg, T. M., McAllister, C., Pyatt, R. E., Ramirez, N. C., Tabler, T. R., Vanhoose, N., White, P., Wise, L., Zmuda, E., Barnabas, N., Berry-Green, C., Blanc, V., Boice, L., Button, M., Farkas, A., Green, A., MacKenzie, J., Nicholson, D., Kalloger, S. E., Blake Gilks, C., Karlan, B. Y., Lester, J., Orsulic, S., Borowsky, M., Cadungog, M., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Witkin, G., Nemirovich-Danchenko, E., Potapova, O., Rotin, D., Berchuck, A., Birrer, M., Disaia, P., Monovich, L., Curley, E., Gardner, J., Mallery, D., Penny, R., Dowdy, S. C., Winterhoff, B., Dao, L., Gostout, B., Meuter, A., Teoman, A., Dao, F., Olvera, N., Bogomolniy, F., Garg, K., Soslow, R. A., Abramov, M., Bartlett, J. M. S., Kodeeswaran, S., Parfitt, J., Moiseenko, F., Clarke, B. A., Goodman, M. T., Carney, M. E., Matsuno, R. K., Fisher, J., Huang, M., Kimryn Rathmell, W., Thorne, L., Van Le, L., Dhir, R., Edwards, R., Elishaev, E., Zorn, K., Goodfellow, P. J., Mutch, D., Kahn, A. B., Bell, D. W., Pollock, P. M., Wang, C., Wheeler, D., Shinbrot, E., Gordon Robertson, A., Ding, L., Blake Gilks, C., Mardis, E. R., Ayala, B., Chu, A. L., Jensen, M. A., Kothiyal, P., Pihl, T. D., Pontius, J., Pot, D. A., Snyder, E. E., Srinivasan, D., Mills Shaw, K. R., Sheth, M., Davidsen, T., Eley, G., Ferguson, M. L., Yang, L., Guyer, M. S., Ozenberger, B. A., Sofia, H. J., Gordon Robertson, A. & Levine, D. A., 2013, In: Nature. 497, 7447, p. 67-73 7 p.

    Research output: Contribution to journal › Article › peer-review

    3629 Scopus citations

  • Modelling gene expression profiles related to prostate tumor progression using binary states

    Martinez, E. & Trevino, V., 2013, In: Theoretical Biology and Medical Modelling. 10, 1, 37.

    Research output: Contribution to journal › Article › peer-review

    5 Scopus citations

  • Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: Effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells

    Bolzoni, M., Donofrio, G., Storti, P., Guasco, D., Toscani, D., Lazzaretti, M., Bonomini, S., Agnelli, L., Capocefalo, A., Dalla Palma, B., Neri, A., Nicolini, F., Lisignoli, G., Russo, F., Colla, S., Aversa, F. & Giuliani, N., Feb 2013, In: Leukemia. 27, 2, p. 451-463 13 p.

    Research output: Contribution to journal › Article › peer-review

    44 Scopus citations

  • Navigating the therapeutic complexity of PI3K pathway inhibition in melanoma

    Kwong, L. N. & Davies, M. A., Oct 1 2013, In: Clinical Cancer Research. 19, 19, p. 5310-5319 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    76 Scopus citations

  • Neutralization of terminal differentiation in gliomagenesis

    Hu, J., Ho, A. L., Yuan, L., Hu, B., Hua, S., Hwang, S. S., Zhang, J., Hu, T., Zheng, H., Gan, B., Wu, G., Wang, Y. A., Chin, L. & DePinho, R. A., Sep 3 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 36, p. 14520-14527 8 p.

    Research output: Contribution to journal › Article › peer-review

    63 Scopus citations

  • Nozzle: A report generation toolkit for data analysis pipelines

    Gehlenborg, N., Noble, M. S., Getz, G., Chin, L. & Park, P. J., Apr 15 2013, In: Bioinformatics. 29, 8, p. 1089-1091 3 p.

    Research output: Contribution to journal › Article › peer-review

    17 Scopus citations

  • Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex

    Wise, J. F., Berkova, Z., Mathur, R., Zhu, H., Braun, F. K., Tao, R. H., Sabichi, A. L., Ao, X., Maeng, H. & Samaniego, F., Jun 6 2013, In: Blood. 121, 23, p. 4729-4739 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    68 Scopus citations

  • PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis

    Jun, S., Lee, S., Kim, H. C., Ng, C., Schneider, A. M., Ji, H., Ying, H., Wang, H., DePinho, R. A. & Park, J. I., 2013, In: Cell Reports. 5, 2, p. 314-322 9 p.

    Research output: Contribution to journal › Article › peer-review

    38 Scopus citations

  • Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment

    Zhang, Y., Chen, L. Y., Han, X., Xie, W., Kim, H., Yang, D., Liu, D. & Songyang, Z., Apr 2 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5457-5462 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    57 Scopus citations

  • Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds

    Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., Zhao, T., Ye, J., Yang, W., Liu, K., Ge, J., Xu, J., Zhang, Q., Zhao, Y. & Deng, H., 2013, In: Science. 341, 6146, p. 651-654 4 p.

    Research output: Contribution to journal › Article › peer-review

    1088 Scopus citations

  • Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

    Verhaak, R. G. W., Tamayo, P., Yang, J. Y., Hubbard, D., Zhang, H., Creighton, C. J., Fereday, S., Lawrence, M., Carter, S. L., Mermel, C. H., Kostic, A. D., Etemadmoghadam, D., Saksena, G., Cibulskis, K., Duraisamy, S., Levanon, K., Sougnez, C., Tsherniak, A., Gomez, S., Onofrio, R., & 21 othersGabriel, S., Chin, L., Zhang, N., Spellman, P. T., Zhang, Y., Akbani, R., Hoadley, K. A., Kahn, A., Köbel, M., Huntsman, D., Soslow, R. A., Defazio, A., Birrer, M. J., Gray, J. W., Weinstein, J. N., Bowtell, D. D., Drapkin, R., Mesirov, J. P., Getz, G., Levine, D. A. & Meyerson, M., Jan 2 2013, In: Journal of Clinical Investigation. 123, 1, p. 517-525 9 p.

    Research output: Contribution to journal › Article › peer-review

    455 Scopus citations

  • Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

    Du, W., Yi, Y., Zhang, H., Bergholz, J., Wu, J., Ying, H., Zhang, Y. & Xiao, Z. X. J., Apr 30 2013, In: PloS one. 8, 4, e63179.

    Research output: Contribution to journal › Article › peer-review

    14 Scopus citations

  • Semiconductor-based DNA sequencing of histone modification states

    Cheng, C. S., Rai, K., Garber, M., Hollinger, A., Robbins, D., Anderson, S., Macbeth, A., Tzou, A., Carneiro, M. O., Raychowdhury, R., Russ, C., Hacohen, N., Gershenwald, J. E., Lennon, N., Nusbaum, C., Chin, L., Regev, A. & Amit, I., Oct 25 2013, In: Nature communications. 4, 2672.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Single-cell paired-end genome sequencing reveals structural variation per cell cycle

    Voet, T., Kumar, P., Van Loo, P., Cooke, S. L., Marshall, J., Lin, M. L., Esteki, M. Z., Van Der Aa, N., Mateiu, L., McBride, D. J., Bignell, G. R., McLaren, S., Teague, J., Butler, A., Raine, K., Stebbings, L. A., Quail, M. A., D'Hooghe, T., Moreau, Y., Futreal, P. A., & 3 othersStratton, M. R., Vermeesch, J. R. & Campbell, P. J., Jul 2013, In: Nucleic acids research. 41, 12, p. 6119-6138 20 p.

    Research output: Contribution to journal › Article › peer-review

    124 Scopus citations

  • Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion

    Vanderslice, P., Biediger, R. J., Woodside, D. G., Brown, W. S., Khounlo, S., Warier, N. D., Gundlach IV, C. W., Caivano, A. R., Bornmann, W. G., Maxwell, D. S., McIntyre, B. W., Willerson, J. T. & Dixon, R. A. F., Jul 5 2013, In: Journal of Biological Chemistry. 288, 27, p. 19414-19428 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    24 Scopus citations

  • SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis

    Aguirre-Gamboa, R., Gomez-Rueda, H., Martínez-Ledesma, E., Martínez-Torteya, A., Chacolla-Huaringa, R., Rodriguez-Barrientos, A., Tamez-Peña, J. G. & Treviño, V., Sep 16 2013, In: PloS one. 8, 9, e74250.

    Research output: Contribution to journal › Article › peer-review

    579 Scopus citations

  • The cancer genome atlas pan-cancer analysis project

    Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Sander, C., Stuart, J. M., Chang, K., Creighton, C. J., Davis, C., Donehower, L., Drummond, J., Wheeler, D., Ally, A., Balasundaram, M., Birol, I., Butterfield, Y. S. N., Chu, A., Chuah, E., & 316 othersChun, H. J. E., Dhalla, N., Guin, R., Hirst, M., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Robertson, A. G., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Varhol, R. J., Beroukhim, R., Bhatt, A. S., Brooks, A. N., Cherniack, A. D., Freeman, S. S., Gabriel, S. B., Helman, E., Jung, J., Meyerson, M., Ojesina, A. I., Pedamallu, C. S., Saksena, G., Schumacher, S. E., Tabak, B., Zack, T., Lander, E. S., Bristow, C. A., Hadjipanayis, A., Haseley, P., Kucherlapati, R., Lee, S., Lee, E., Luquette, L. J., Mahadeshwar, H. S., Pantazi, A., Parfenov, M., Park, P. J., Protopopov, A., Ren, X., Santoso, N., Seidman, J., Seth, S., Song, X., Tang, J., Xi, R., Xu, A. W., Yang, L., Zeng, D., Auman, J. T., Balu, S., Buda, E., Fan, C., Hoadley, K. A., Jones, C. D., Meng, S., Mieczkowski, P. A., Parker, J. S., Perou, C. M., Roach, J., Shi, Y., Silva, G. O., Tan, D., Veluvolu, U., Waring, S., Wilkerson, M. D., Wu, J., Zhao, W., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jeffreys, S. R., Mose, L. E., Simons, J. V., Soloway, M. G., Baylin, S. B., Berman, B. P., Bootwalla, M. S., Danilova, L., Herman, J. G., Hinoue, T., Laird, P. W., Rhie, S. K., Shen, H., Triche, T., Weisenberger, D. J., Carter, S. L., Cibulskis, K., Chin, L., Zhang, J., Sougnez, C., Wang, M., Getz, G., Dinh, H., Doddapaneni, H. V., Gibbs, R., Gunaratne, P., Han, Y., Kalra, D., Kovar, C., Lewis, L., Morgan, M., Morton, D., Muzny, D., Reid, J., Xi, L., Cho, J., Dicara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Liu, Y., Noble, M. S., Stojanov, P., Voet, D., Zhang, H., Zou, L., Stewart, C., Bernard, B., Bressler, R., Eakin, A., Iype, L., Knijnenburg, T., Kramer, R., Kreisberg, R., Leinonen, K., Lin, J., Liu, Y., Miller, M., Reynolds, S. M., Rovira, H., Shmulevich, I., Thorsson, V., Yang, D., Zhang, W., Amin, S., Wu, C. J., Wu, C. C., Akbani, R., Aldape, K., Baggerly, K. A., Broom, B., Casasent, T. D., Cleland, J., Dodda, D., Edgerton, M., Han, L., Herbrich, S. M., Ju, Z., Kim, H., Lerner, S., Li, J., Liang, H., Liu, W., Lorenzi, P. L., Lu, Y., Melott, J., Nguyen, L., Su, X., Verhaak, R., Wang, W., Wong, A., Yang, Y., Yao, J., Yao, R., Yoshihara, K., Yuan, Y., Yung, A. K., Zhang, N., Zheng, S., Ryan, M., Kane, D. W., Aksoy, B. A., Ciriello, G., Dresdner, G., Gao, J., Gross, B., Jacobsen, A., Kahles, A., Ladanyi, M., Lee, W., Lehmann, K. V., Miller, M. L., Ramirez, R., Rätsch, G., Reva, B., Schultz, N., Senbabaoglu, Y., Shen, R., Sinha, R., Sumer, S. O., Sun, Y., Taylor, B. S., Weinhold, N., Fei, S., Spellman, P., Benz, C., Carlin, D., Cline, M., Craft, B., Goldman, M., Haussler, D., Ma, S., Ng, S., Paull, E., Radenbaugh, A., Salama, S., Sokolov, A., Swatloski, T., Uzunangelov, V., Waltman, P., Yau, C., Zhu, J., Hamilton, S. R., Abbott, S., Abbott, R., Dees, N. D., Delehaunty, K., Ding, L., Dooling, D. J., Eldred, J. M., Fronick, C. C., Fulton, R., Fulton, L. L., Kalicki-Veizer, J., Kanchi, K. L., Kandoth, C., Koboldt, D. C., Larson, D. E., Ley, T. J., Lin, L., Lu, C., Magrini, V. J., Mardis, E. R., McLellan, M. D., McMichael, J. F., Miller, C. A., O'Laughlin, M., Pohl, C., Schmidt, H., Smith, S. M., Walker, J., Wallis, J. W., Wendl, M. C., Wilson, R. K., Wylie, T., Zhang, Q., Burton, R., Jensen, M. A., Kahn, A., Pihl, T., Pot, D., Wan, Y., Levine, D. A., Black, A. D., Bowen, J., Frick, J., Gastier-Foster, J. M., Harper, H. A., Helsel, C., Leraas, K. M., Lichtenberg, T. M., McAllister, C., Ramirez, N. C., Sharpe, S., Wise, L., Zmuda, E., Chanock, S. J., Davidsen, T., Demchok, J. A., Eley, G., Felau, I., Sheth, M., Sofia, H., Staudt, L., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J., Omberg, L., Margolin, A., Raphael, B. J., Vandin, F., Wu, H. T., Leiserson, M. D. M., Benz, S. C., Vaske, C. J., Noushmehr, H., Wolf, D., Veer, L. V. T., Anastassiou, D., Yang, T. H. O., Lopez-Bigas, N., Gonzalez-Perez, A., Tamborero, D., Xia, Z., Li, W., Cho, D. Y., Przytycka, T., Hamilton, M., McGuire, S., Nelander, S., Johansson, P., Jörnsten, R. & Kling, T., Oct 1 2013, In: Nature Genetics. 45, 10, p. 1113-1120 8 p.

    Research output: Contribution to journal › Article › peer-review

    5099 Scopus citations

  • The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

    Yen, J., White, R. M., Wedge, D. C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I. R., Wu, C. J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., & 20 othersWhitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O'Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D. J., Zon, L. I., Patton, E. E., Stemple, D. L. & Futreal, P. A., Oct 23 2013, In: Genome biology. 14, 10, R113.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model

    Pizzimenti, S., Ciamporcero, E., Pettazzoni, P., Osella-Abate, S., Novelli, M., Toaldo, C., Husse, M., Daga, M., Minelli, R., Bisazza, A., Ferruti, P., Ranucci, E., Grazia Bernengo, M., Dianzani, C., Biasi, F., Cavalli, R. & Barrera, G., 2013, In: Free Radical Biology and Medicine. 65, p. 765-777 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • The somatic genomic landscape of glioblastoma

    TCGA Research Network, Oct 10 2013, In: Cell. 155, 2, p. 462 1 p.

    Research output: Contribution to journal › Article › peer-review

    3492 Scopus citations

  • The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells

    Marangoni, F., Murooka, T. T., Manzo, T., Kim, E. Y., Carrizosa, E., Elpek, N. M. & Mempel, T. R., Feb 21 2013, In: Immunity. 38, 2, p. 237-249 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    126 Scopus citations