Andrew Futreal

View Scopus Profile

Andrew Futreal

Professor

 https://orcid.org/0000-0001-8663-2671

    • 6767 Bertner Ave, Mitchell Basic Science Research Building

      77030 Houston

      United States

    Calculated based on number of publications stored in Pure and citations from Scopus
    1991 …2024

    Research activity per year

    Filter
    Article

    Search results

    • 2009

      A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation

      Tarpey, P. S., Smith, R., Pleasance, E., Whibley, A., Edkins, S., Hardy, C., O'Meara, S., Latimer, C., Dicks, E., Menzies, A., Stephens, P., Blow, M., Greenman, C., Xue, Y., Tyler-Smith, C., Thompson, D., Gray, K., Andrews, J., Barthorpe, S., Buck, G., & 59 othersCole, J., Dunmore, R., Jones, D., Maddison, M., Mironenko, T., Turner, R., Turrell, K., Varian, J., West, S., Widaa, S., Wray, P., Teague, J., Butler, A., Jenkinson, A., Jia, M., Richardson, D., Shepherd, R., Wooster, R., Tejada, M. I., Martinez, F., Carvill, G., Goliath, R., De Brouwer, A. P. M., Van Bokhoven, H., Van Esch, H., Chelly, J., Raynaud, M., Ropers, H. H., Abidi, F. E., Srivastava, A. K., Cox, J., Luo, Y., Mallya, U., Moon, J., Parnau, J., Mohammed, S., Tolmie, J. L., Shoubridge, C., Corbett, M., Gardner, A., Haan, E., Rujirabanjerd, S., Shaw, M., Vandeleur, L., Fullston, T., Easton, D. F., Boyle, J., Partington, M., Hackett, A., Field, M., Skinner, C., Stevenson, R. E., Bobrow, M., Turner, G., Schwartz, C. E., Gecz, J., Raymond, F. L., Futreal, P. A. & Stratton, M. R., May 2009, In: Nature Genetics. 41, 5, p. 535-543 9 p.

      Research output: Contribution to journal › Article › peer-review

      486 Scopus citations

    • Complex landscapes of somatic rearrangement in human breast cancer genomes

      Stephens, P. J., McBride, D. J., Lin, M. L., Varela, I., Pleasance, E. D., Simpson, J. T., Stebbings, L. A., Leroy, C., Edkins, S., Mudie, L. J., Greenman, C. D., Jia, M., Latimer, C., Teague, J. W., Lau, K. W., Burton, J., Quail, M. A., Swerdlow, H., Churcher, C., Natrajan, R., & 13 othersSieuwerts, A. M., Martens, J. W. M., Silver, D. P., Langerød, A., Russnes, H. E. G., Foekens, J. A., Reis-Filho, J. S., Van T Veer, L., Richardson, A. L., Børresen-Dale, A. L., Campbell, P. J., Futreal, P. A. & Stratton, M. R., Dec 24 2009, In: Nature. 462, 7276, p. 1005-1010 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      709 Scopus citations

    • COSMIC (the Catalogue of Somatic Mutations In Cancer): A resource to investigate acquired mutations in human cancer

      Forbes, S. A., Tang, G., Bindal, N., Bamford, S., Dawson, E., Cole, C., Kok, C. Y., Jia, M., Ewing, R., Menzies, A., Teague, J. W., Stratton, M. R. & Futreal, P. A., Nov 10 2009, In: Nucleic acids research. 38, SUPPL.1, p. D652-D657 gkp995.

      Research output: Contribution to journal › Article › peer-review

      461 Scopus citations

    • LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition

      Mahoney, C. L., Choudhury, B., Davies, H., Edkins, S., Greenman, C., Haaften, G. V., Mironenko, T., Santarius, T., Stevens, C., Stratton, M. R. & Futreal, P. A., Jan 27 2009, In: British journal of cancer. 100, 2, p. 370-375 6 p.

      Research output: Contribution to journal › Article › peer-review

      104 Scopus citations

    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

      Van Haaften, G., Dalgliesh, G. L., Davies, H., Chen, L., Bignell, G., Greenman, C., Edkins, S., Hardy, C., O'Meara, S., Teague, J., Butler, A., Hinton, J., Latimer, C., Andrews, J., Barthorpe, S., Beare, D., Buck, G., Campbell, P. J., Cole, J., Forbes, S., & 42 othersJia, M., Jones, D., Kok, C. Y., Leroy, C., Lin, M. L., McBride, D. J., Maddison, M., Maquire, S., McLay, K., Menzies, A., Mironenko, T., Mulderrig, L., Mudie, L., Pleasance, E., Shepherd, R., Smith, R., Stebbings, L., Stephens, P., Tang, G., Tarpey, P. S., Turner, R., Turrell, K., Varian, J., West, S., Widaa, S., Wray, P., Collins, V. P., Ichimura, K., Law, S., Wong, J., Yuen, S. T., Leung, S. Y., Tonon, G., Depinho, R. A., Tai, Y. T., Anderson, K. C., Kahnoski, R. J., Massie, A., Khoo, S. K., Teh, B. T., Stratton, M. R. & Futreal, P. A., May 2009, In: Nature Genetics. 41, 5, p. 521-523 3 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      672 Scopus citations
    • 2008

      Exclusion of biglycan mutations in a cohort of patients with neuromuscular disorders

      Peat, R. A., Gécz, J., Fallon, J. R., Tarpey, P. S., Smith, R., Futreal, A., Stratton, M. R., Lamandé, S. R., Yang, N. & North, K. N., Aug 2008, In: Neuromuscular Disorders. 18, 8, p. 606-609 4 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      3 Scopus citations

    • Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

      Wiedemeyer, R., Brennan, C., Heffernan, T. P., Xiao, Y., Mahoney, J., Protopopov, A., Zheng, H., Bignell, G., Furnari, F., Cavenee, W. K., Hahn, W. C., Ichimura, K., Collins, V. P., Chu, G. C., Stratton, M. R., Ligon, K. L., Futreal, P. A. & Chin, L., Apr 8 2008, In: Cancer cell. 13, 4, p. 355-364 10 p.

      Research output: Contribution to journal › Article › peer-review

      108 Scopus citations

    • Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

      Kimmelman, A. C., Hezel, A. F., Aguirre, A. J., Zheng, H., Paik, J. H., Ying, H., Chu, G. C., Zhang, J. X., Sahin, E., Yeo, G., Ponugoti, A., Nabioullin, R., Deroo, S., Yang, S., Wang, X., McGrath, J. P., Protopopova, M., Ivanova, E., Zhang, J., Feng, B., & 9 othersTsao, M. S., Redston, M., Protopopov, A., Xiao, Y., Futreal, P. A., Hahn, W. C., Klimstr, D. S., Chin, L. & DePinho, R. A., Dec 9 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 49, p. 19372-19377 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      128 Scopus citations

    • Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

      Campbell, P. J., Stephens, P. J., Pleasance, E. D., O'Meara, S., Li, H., Santarius, T., Stebbings, L. A., Leroy, C., Edkins, S., Hardy, C., Teague, J. W., Menzies, A., Goodhead, I., Turner, D. J., Clee, C. M., Quail, M. A., Cox, A., Brown, C., Durbin, R., Hurles, M. E., & 4 othersEdwards, P. A. W., Bignell, G. R., Stratton, M. R. & Futreal, P. A., Jun 2008, In: Nature Genetics. 40, 6, p. 722-729 8 p.

      Research output: Contribution to journal › Article › peer-review

      681 Scopus citations

    • In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation

      Ikediobi, O. N., Reimers, M., Durinck, S., Blower, P. E., Futreal, A. P., Stratton, M. R. & Weinstein, J. N., 2008, In: Molecular cancer therapeutics. 7, 6, p. 1337-1346 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      13 Scopus citations

    • Oligosaccharyltransferase-Subunit Mutations in Nonsyndromic Mental Retardation

      Molinari, F., Foulquier, F., Tarpey, P. S., Morelle, W., Boissel, S., Teague, J., Edkins, S., Futreal, P. A., Stratton, M. R., Turner, G., Matthijs, G., Gecz, J., Munnich, A. & Colleaux, L., May 9 2008, In: American journal of human genetics. 82, 5, p. 1150-1157 8 p.

      Research output: Contribution to journal › Article › peer-review

      124 Scopus citations

    • Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genes

      Jaeckle Santos, L. J., Xing, C., Barnes, R. B., Ades, L. C., Megarbane, A., Vidal, C., Xuereb, A., Tarpey, P. S., Smith, R., Khazab, M., Shoubridge, C., Partington, M., Futreal, A., Stratton, M. R., Gecz, J. & Zinn, A. R., Jun 2008, In: Human genetics. 123, 5, p. 469-476 8 p.

      Research output: Contribution to journal › Article › peer-review

      16 Scopus citations

    • SLC9A6 Mutations Cause X-Linked Mental Retardation, Microcephaly, Epilepsy, and Ataxia, a Phenotype Mimicking Angelman Syndrome

      Gilfillan, G. D., Selmer, K. K., Roxrud, I., Smith, R., Kyllerman, M., Eiklid, K., Kroken, M., Mattingsdal, M., Egeland, T., Stenmark, H., Sjøholm, H., Server, A., Samuelsson, L., Christianson, A., Tarpey, P., Whibley, A., Stratton, M. R., Futreal, P. A., Teague, J., Edkins, S., & 7 othersGecz, J., Turner, G., Raymond, F. L., Schwartz, C., Stevenson, R. E., Undlien, D. E. & Strømme, P., Apr 11 2008, In: American journal of human genetics. 82, 4, p. 1003-1010 8 p.

      Research output: Contribution to journal › Article › peer-review

      180 Scopus citations

    • Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

      Campbell, P. J., Pleasance, E. D., Stephens, P. J., Dicks, E., Rance, R., Goodhead, I., Follows, G. A., Green, A. R., Futreal, P. A. & Stratton, M. R., Sep 2 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 13081-13086 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      289 Scopus citations

    • Submicroscopic Duplications of the Hydroxysteroid Dehydrogenase HSD17B10 and the E3 Ubiquitin Ligase HUWE1 Are Associated with Mental Retardation

      Froyen, G., Corbett, M., Vandewalle, J., Jarvela, I., Lawrence, O., Meldrum, C., Bauters, M., Govaerts, K., Vandeleur, L., Van Esch, H., Chelly, J., Sanlaville, D., van Bokhoven, H., Ropers, H. H., Laumonnier, F., Ranieri, E., Schwartz, C. E., Abidi, F., Tarpey, P. S., Futreal, P. A., & 14 othersWhibley, A., Raymond, F. L., Stratton, M. R., Fryns, J. P., Scott, R., Peippo, M., Sipponen, M., Partington, M., Mowat, D., Field, M., Hackett, A., Marynen, P., Turner, G. & Gécz, J., Feb 8 2008, In: American journal of human genetics. 82, 2, p. 432-443 12 p.

      Research output: Contribution to journal › Article › peer-review

      172 Scopus citations

    • The catalogue of somatic mutations in cancer (COSMIC)

      Forbes, S. A., Bhamra, G., Bamford, S., Dawson, E., Kok, C., Clements, J., Menzies, A., Teague, J. W., Futreal, P. A. & Stratton, M. R., 2008, In: Current Protocols in Human Genetics. SUPPL. 57, p. 10.11.1-10.11.26

      Research output: Contribution to journal › Article › peer-review

      641 Scopus citations

    • X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment

      Dibbens, L. M., Tarpey, P. S., Hynes, K., Bayly, M. A., Scheffer, I. E., Smith, R., Bomar, J., Sutton, E., Vandeleur, L., Shoubridge, C., Edkins, S., Turner, S. J., Stevens, C., O'Meara, S., Tofts, C., Barthorpe, S., Buck, G., Cole, J., Halliday, K., Jones, D., & 37 othersLee, R., Madison, M., Mironenko, T., Varian, J., West, S., Widaa, S., Wray, P., Teague, J., Dicks, E., Butler, A., Menzies, A., Jenkinson, A., Shepherd, R., Gusella, J. F., Afawi, Z., Mazarib, A., Neufeld, M. Y., Kivity, S., Lev, D., Lerman-Sagie, T., Korczyn, A. D., Derry, C. P., Sutherland, G. R., Friend, K., Shaw, M., Corbett, M., Kim, H. G., Geschwind, D. H., Thomas, P., Haan, E., Ryan, S., McKee, S., Berkovic, S. F., Futreal, P. A., Stratton, M. R., Mulley, J. C. & Gécz, J., Jun 2008, In: Nature Genetics. 40, 6, p. 776-781 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      363 Scopus citations
    • 2007

      Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution

      Bignell, G. R., Santarius, T., Pole, J. C. M., Butler, A. P., Perry, J., Pleasance, E., Greenman, C., Menzies, A., Taylor, S., Edkins, S., Campbell, P., Quail, M., Plumb, B., Matthews, L., McLay, K., Edwards, P. A. W., Rogers, J., Wooster, R., Futreal, P. A. & Stratton, M. R., Sep 2007, In: Genome research. 17, 9, p. 1296-1303 8 p.

      Research output: Contribution to journal › Article › peer-review

      158 Scopus citations

    • AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes

      Dicks, E., Teague, J. W., Stephens, P., Raine, K., Yates, A., Mattocks, C., Tarpey, P., Butler, A., Menzies, A., Richardson, D., Jenkinson, A., Davies, H., Edkins, S., Forbes, S., Gray, K., Greenman, C., Shepherd, R., Stratton, M. R., Futreal, P. A. & Wooster, R., Jul 1 2007, In: Bioinformatics. 23, 13, p. 1689-1691 3 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      14 Scopus citations

    • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

      Maser, R. S., Choudhury, B., Campbell, P. J., Feng, B., Wong, K. K., Protopopov, A., O'Neil, J., Gutierrez, A., Ivanova, E., Perna, I., Lin, E., Mani, V., Jiang, S., McNamara, K., Zaghlul, S., Edkins, S., Stevens, C., Brennan, C., Martin, E. S., Wiedemeyer, R., & 16 othersKabbarah, O., Nogueira, C., Histen, G., Aster, J., Mansour, M., Duke, V., Foroni, L., Fielding, A. K., Goldstone, A. H., Rowe, J. M., Wang, Y. A., Look, A. T., Stratton, M. R., Chin, L., Futreal, P. A. & DePinho, R. A., Jun 21 2007, In: Nature. 447, 7147, p. 966-971 6 p.

      Research output: Contribution to journal › Article › peer-review

      319 Scopus citations

    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

      Pollock, P. M., Gartside, M. G., Dejeza, L. C., Powell, M. A., Mallon, M. A., Davies, H., Mohammadi, M., Futreal, P. A., Stratton, M. R., Trent, J. M. & Goodfellow, P. J., Nov 1 2007, In: Oncogene. 26, 50, p. 7158-7162 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      257 Scopus citations

    • JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

      Scott, L. M., Tong, W., Levine, R. L., Scott, M. A., Beer, P. A., Stratton, M. R., Futreal, P. A., Erber, W. N., McMullin, M. F., Harrison, C. N., Warren, A. J., Gilliland, D. G., Lodish, H. F. & Green, A. R., Feb 1 2007, In: New England Journal of Medicine. 356, 5, p. 459-468 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1060 Scopus citations

    • Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment

      Cahill, D. P., Levine, K. K., Betensky, R. A., Codd, P. J., Romany, C. A., Reavie, L. B., Batchelor, T. T., Futreal, P. A., Stratton, M. R., Curry, W. T., Lafrate, A. J. & Louis, D. N., Apr 1 2007, In: Clinical Cancer Research. 13, 7, p. 2038-2045 8 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      350 Scopus citations

    • Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

      Tarpey, P. S., Raymond, F. L., O'Meara, S., Edkins, S., Teague, J., Butler, A., Dicks, E., Stevens, C., Tofts, C., Avis, T., Barthorpe, S., Buck, G., Cole, J., Gray, K., Halliday, K., Harrison, R., Hills, K., Jenkinson, A., Jones, D., Menzies, A., & 33 othersMironenko, T., Perry, J., Raine, K., Richardson, D., Shepherd, R., Small, A., Varian, J., West, S., Widaa, S., Mallya, U., Moon, J., Luo, Y., Holder, S., Smithson, S. F., Hurst, J. A., Clayton-Smith, J., Kerr, B., Boyle, J., Shaw, M., Vandeleur, L., Rodriguez, J., Slaugh, R., Easton, D. F., Wooster, R., Bobrow, M., Srivastava, A. K., Stevenson, R. E., Schwartz, C. E., Turner, G., Gecz, J., Futreal, P. A., Stratton, M. R. & Partington, M., Feb 2007, In: American journal of human genetics. 80, 2, p. 345-352 8 p.

      Research output: Contribution to journal › Article › peer-review

      186 Scopus citations

    • Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans

      Wu, Y., Arai, A. C., Rumbaugh, G., Srivastava, A. K., Turner, G., Hayashi, T., Suzuki, E., Jiang, Y., Zhang, L., Rodriguez, J., Boyle, J., Tarpey, P., Raymond, F. L., Nevelsteen, J., Froyen, G., Stratton, M., Futreal, A., Gecz, J., Stevenson, R., Schwartz, C. E., & 3 othersValle, D., Huganir, R. L. & Wang, T., Nov 13 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18163-18168 6 p.

      Research output: Contribution to journal › Article › peer-review

      90 Scopus citations

    • Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly

      Field, M., Tarpey, P. S., Smith, R., Edkins, S., O'Meara, S., Stevens, C., Tofts, C., Teague, J., Butler, A., Dicks, E., Barthorpe, S., Buck, G., Cole, J., Gray, K., Halliday, K., Hills, K., Jenkinson, A., Jones, D., Menzies, A., Mironenko, T., & 26 othersPerry, J., Raine, K., Richardson, D., Shepherd, R., Small, A., Varian, J., West, S., Widaa, S., Mallya, U., Wooster, R., Moon, J., Luo, Y., Hughes, H., Shaw, M., Friend, K. L., Corbett, M., Turner, G., Partington, M., Mulley, J., Bobrow, M., Schwartz, C., Stevenson, R., Gecz, J., Stratton, M. R., Futreal, P. A. & Raymond, F. L., Aug 2007, In: American journal of human genetics. 81, 2, p. 367-374 8 p.

      Research output: Contribution to journal › Article › peer-review

      71 Scopus citations

    • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

      Tarpey, P. S., Lucy Raymond, F., Nguyen, L. S., Rodriguez, J., Hackett, A., Vandeleur, L., Smith, R., Shoubridge, C., Edkins, S., Stevens, C., O'Meara, S., Tofts, C., Barthorpe, S., Buck, G., Cole, J., Halliday, K., Hills, K., Jones, D., Mironenko, T., Perry, J., & 37 othersVarian, J., West, S., Widaa, S., Teague, J., Dicks, E., Butler, A., Menzies, A., Richardson, D., Jenkinson, A., Shepherd, R., Raine, K., Moon, J., Luo, Y., Parnau, J., Bhat, S. S., Gardner, A., Corbett, M., Brooks, D., Thomas, P., Parkinson-Lawrence, E., Porteous, M. E., Warner, J. P., Sanderson, T., Pearson, P., Simensen, R. J., Skinner, C., Hoganson, G., Superneau, D., Wooster, R., Bobrow, M., Turner, G., Stevenson, R. E., Schwartz, C. E., Andrew Futreal, P., Srivastava, A. K., Stratton, M. R. & Gécz, J., Sep 2007, In: Nature Genetics. 39, 9, p. 1127-1133 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      208 Scopus citations

    • Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus

      Raymond, F. L., Tarpey, P. S., Edkins, S., Tofts, C., O'Meara, S., Teague, J., Butler, A., Stevens, C., Barthorpe, S., Buck, G., Cole, J., Dicks, E., Gray, K., Halliday, K., Hills, K., Hinton, J., Jones, D., Menzies, A., Perry, J., Raine, K., & 20 othersShepherd, R., Small, A., Varian, J., Widaa, S., Mallya, U., Moon, J., Luo, Y., Shaw, M., Boyle, J., Kerr, B., Turner, G., Quarrell, O., Cole, T., Easton, D. F., Wooster, R., Bobrow, M., Schwartz, C. E., Gecz, J., Stratton, M. R. & Futreal, P. A., May 2007, In: American journal of human genetics. 80, 5, p. 982-987 6 p.

      Research output: Contribution to journal › Article › peer-review

      135 Scopus citations

    • Patterns of somatic mutation in human cancer genomes

      Greenman, C., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G., Davies, H., Teague, J., Butler, A., Stevens, C., Edkins, S., O'Meara, S., Vastrik, I., Schmidt, E. E., Avis, T., Barthorpe, S., Bhamra, G., Buck, G., Choudhury, B., Clements, J., & 46 othersCole, J., Dicks, E., Forbes, S., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jenkinson, A., Jones, D., Menzies, A., Mironenko, T., Perry, J., Raine, K., Richardson, D., Shepherd, R., Small, A., Tofts, C., Varian, J., Webb, T., West, S., Widaa, S., Yates, A., Cahill, D. P., Louis, D. N., Goldstraw, P., Nicholson, A. G., Brasseur, F., Looijenga, L., Weber, B. L., Chiew, Y. E., DeFazio, A., Greaves, M. F., Green, A. R., Campbell, P., Birney, E., Easton, D. F., Chenevix-Trench, G., Tan, M. H., Khoo, S. K., Teh, B. T., Yuen, S. T., Leung, S. Y., Wooster, R., Futreal, P. A. & Stratton, M. R., Mar 8 2007, In: Nature. 446, 7132, p. 153-158 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2500 Scopus citations

    • The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene

      Schwartz, C. E., Tarpey, P. S., Lubs, H. A., Verloes, A., May, M. M., Risheg, H., Friez, M. J., Futreal, P. A., Edkins, S., Teague, J., Briault, S., Skinner, C., Bauer-Carlin, A., Simensen, R. J., Joseph, S. M., Jones, J. R., Gecz, J., Stratton, M. R., Raymond, F. L. & Stevenson, R. E., Jul 2007, In: Journal of medical genetics. 44, 7, p. 472-477 6 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      149 Scopus citations
    • 2006

      A genome wide linkage search for breast cancer susceptibility genes

      Smith, P., McGuffog, L., Easton, D. F., Mann, G. J., Pupo, G. M., Newman, B., Chenevix-Trench, G., Szabo, C., Southey, M., Renard, H., Odefrey, F., Lynch, H., Stoppa-Lyonnet, D., Couch, F., Hopper, J. L., Giles, G. G., McCredie, M. R. E., Buys, S., Andrulis, I., Senie, R., & 27 othersGoldgar, D. E., Oldenburg, R., Kroeze-Jansema, K., Kraan, J., Meijers-Heijboer, H., Klijn, J. G. M., Van Asperen, C., Van Leeuwen, I., Vasen, H. F. A., Cornelisse, C. J., Devilee, P., Baskcomb, L., Seal, S., Barfoot, R., Mangion, J., Hall, A., Edkins, S., Rapley, E., Wooster, R., Chang-Claude, J., Eccles, D., Evans, D. G., Futreal, P. A., Nathanson, K. L., Weber, B. L., Rahman, N. & Stratton, M. R., Jul 2006, In: Genes Chromosomes and Cancer. 45, 7, p. 646-655 10 p.

      Research output: Contribution to journal › Article › peer-review

      110 Scopus citations

    • A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy

      Hunter, C., Smith, R., Cahill, D. P., Stephens, P., Stevens, C., Teague, J., Greenman, C., Edkins, S., Bignell, G., Davies, H., O'Meara, S., Parker, A., Avis, T., Barthorpe, S., Brackenbury, L., Buck, G., Butler, A., Clements, J., Cole, J., Dicks, E., & 35 othersForbes, S., Gorton, M., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jenkinson, A., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Richardson, D., Shepherd, R., Small, A., Solomon, H., Tofts, C., Varian, J., West, S., Widaa, S., Yates, A., Easton, D. F., Riggins, G., Roy, J. E., Levine, K. K., Mueller, W., Batchelor, T. T., Louis, D. N., Stratton, M. R., Futreal, P. A. & Wooster, R., Apr 15 2006, In: Cancer Research. 66, 8, p. 3987-3991 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      351 Scopus citations

    • A multicenter study of cancer incidence in CHEK2 1100delC mutation carriers

      Thompson, D., Seal, S., Schutte, M., McGuffog, L., Barfoot, R., Renwick, A., Eeles, R., Sodha, N., Houlston, R., Shanley, S., Klijn, J., Wasielewski, M., Chang-Claude, J., Futreal, P. A., Weber, B. L., Nathanson, K. L., Stratton, M., Meijers-Heijboer, H., Rahman, N. & Easton, D. F., Dec 2006, In: Cancer Epidemiology Biomarkers and Prevention. 15, 12, p. 2542-2545 4 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      46 Scopus citations

    • Her2-targeted therapies in non-small cell lung cancer

      Swanton, C., Futreal, A., Eisen, T., Engelman, J., Johnson, D., Haber, D., Lynch, T., Johnson, B. & Heymach, J., Jul 15 2006, In: Clinical Cancer Research. 12, 14, p. 4377s-4383s

      Research output: Contribution to journal › Article › peer-review

      72 Scopus citations

    • High throughput DNA sequence variant detection by conformation sensitive capillary electrophoresis and automated peak comparison

      Davies, H., Dicks, E., Stephens, P., Cox, C., Teague, J., Greenman, C., Bignell, G., O'Meara, S., Edkins, S., Parker, A., Stevens, C., Menzies, A., Blow, M., Bottomley, B., Dronsfield, M., Futreal, P. A., Stratton, M. R. & Wooster, R., Mar 2006, In: Genomics. 87, 3, p. 427-432 6 p.

      Research output: Contribution to journal › Article › peer-review

      33 Scopus citations

    • Mutation analysis of 24 known cancer genes in the NCI-60 cell line set

      Ikediobi, O. N., Davies, H., Bignell, G., Edkins, S., Stevens, C., O'Meara, S., Santarius, T., Avis, T., Barthorpe, S., Brakenbury, L., Buck, G., Butler, A., Clements, J., Cole, J., Dicks, E., Forbes, S., Gray, K., Halliday, K., Harrison, R., Hills, K., & 29 othersHinton, J., Hunter, C., Jenkinson, A., Jones, D., Kosmidou, V., Lugg, R., Menzies, A., Mironenko, T., Parker, A., Perry, J., Raine, K., Richardson, D., Shepherd, R., Small, A., Smith, R., Solomon, H., Stephens, P., Teague, J., Tofts, C., Varian, J., Webb, T., West, S., Widaa, S., Yates, A., Reinhold, W., Weinstein, J. N., Stratton, M. R., Futreal, P. A. & Wooster, R., Nov 2006, In: Molecular cancer therapeutics. 5, 11, p. 2606-2612 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      352 Scopus citations

    • Mutations in FRMD7, a newly identified member of the FERM family, cause X-linked idiopathic congenital nystagmus

      Tarpey, P., Thomas, S., Sarvananthan, N., Mallya, U., Lisgo, S., Talbot, C. J., Roberts, E. O., Awan, M., Surendran, M., McLean, R. J., Reinecke, R. D., Langmann, A., Lindner, S., Koch, M., Jain, S., Woodruff, G., Gale, R. P., Degg, C., Droutsas, K., Asproudis, I., & 22 othersZubcov, A. A., Pieh, C., Veal, C. D., MacHado, R. D., Backhouse, O. C., Baumber, L., Constantinescu, C. S., Brodsky, M. C., Hunter, D. G., Hertle, R. W., Read, R. J., Edkins, S., O'Meara, S., Parker, A., Stevens, C., Teague, J., Wooster, R., Futreal, P. A., Trembath, R. C., Stratton, M. R., Raymond, F. L. & Gottlob, I., Nov 23 2006, In: Nature Genetics. 38, 11, p. 1242-1244 3 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      160 Scopus citations

    • Mutations in the gene encoding the sigma 2 subunit of the adaptor protein 1 complex, AP1S2, cause X-linked mental retardation

      Tarpey, P. S., Stevens, C., Teague, J., Edkins, S., O'Meara, S., Avis, T., Barthorpe, S., Buck, G., Butler, A., Cole, J., Dicks, E., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jones, D., Menzies, A., Mironenko, T., Perry, J., & 29 othersRaine, K., Richardson, D., Shepherd, R., Small, A., Tofts, C., Varian, J., West, S., Widaa, S., Yates, A., Catford, R., Butler, J., Mallya, U., Moon, J., Luo, Y., Dorkins, H., Thompson, D., Easton, D. F., Wooster, R., Bobrow, M., Carpenter, N., Simensen, R. J., Schwartz, C. E., Stevenson, R. E., Turner, G., Partington, M., Gecz, J., Stratton, M. R., Futreal, P. A. & Raymond, F. L., Dec 2006, In: American journal of human genetics. 79, 6, p. 1119-1124 6 p.

      Research output: Contribution to journal › Article › peer-review

      95 Scopus citations

    • Mutations in the RSK2(RPS6KA3) gene cause Coffin-Lowry syndrome and nonsyndromic X-linked mental retardation

      Field, M., Tarpey, P., Boyle, J., Edkins, B., Goodship, J., Luo, Y., Moon, J., Teague, J., Stratton, M. R., Futreal, P. A., Wooster, R., Raymond, F. L. & Turner, G., Dec 2006, In: Clinical Genetics. 70, 6, p. 509-515 7 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      29 Scopus citations

    • Recurrent KRAS codon 146 mutations in human colorectal cancer

      Edkins, S., O'Meara, S., Parker, A., Stevens, C., Reis, M., Jones, S., Greenman, C., Davies, H., Dalgliesh, G., Forbes, S., Hunter, C., Smith, R., Stephens, P., Goldstraw, P., Nicholson, A., Tsun, L. C., Velculescu, V. E., Siu, T. Y., Suet, Y. L., Stratton, M. R., & 1 othersFutreal, P. A., Aug 2006, In: Cancer Biology and Therapy. 5, 8, p. 928-932 5 p.

      Research output: Contribution to journal › Article › peer-review

      201 Scopus citations

    • RNA editing of human microRNAs

      Blow, M. J., Grocock, R. J., van Dongen, S., Enright, A. J., Dicks, E., Futreal, P. A., Wooster, R. & Stratton, M. R., Apr 4 2006, In: Genome biology. 7, 4, R27.

      Research output: Contribution to journal › Article › peer-review

      286 Scopus citations

    • Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults

      Bignell, G., Smith, R., Hunter, C., Stephens, P., Davies, H., Greenman, C., Teague, J., Butler, A., Edkins, S., Stevens, C., O'Meara, S., Parker, A., Avis, T., Barthorpe, S., Brackenbury, L., Buck, G., Clements, J., Cole, J., Dicks, E., Edwards, K., & 33 othersForbes, S., Gorton, M., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Shepherd, R., Small, A., Solomon, H., Stephens, Y., Tofts, C., Varian, J., Webb, A., West, S., Widaa, S., Yates, A., Gillis, A. J. M., Stoop, H. J., Van Gurp, R. J. H. L. M., Oosterhuis, J. W., Looijenga, L. H. J., Futreal, P. A., Wooster, R. & Stratton, M. R., 2006, In: Genes Chromosomes and Cancer. 45, 1, p. 42-46 5 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      86 Scopus citations

    • Statistical analysis of pathogenicity of somatic mutations in cancer

      Greenman, C., Wooster, R., Futreal, P. A., Stratton, M. R. & Easton, D. F., 2006, In: Genetics. 173, 4, p. 2187-2198 12 p.

      Research output: Contribution to journal › Article › peer-review

      133 Scopus citations
    • 2005

      Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

      Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., Scott, M. A., Erber, W. N., Avis, T., Barthorpe, A., Bignell, G., Blow, M., Brackenbury, L., Buck, G., Clegg, S., Clements, J., & 46 othersCole, J., Davies, H., Edkins, S., Gray, K., Gorton, M., O'Meara, S., Halliday, K., Harrison, R., Haynes, W., Hills, K., Hunter, C., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Parker, A., Perry, J., Petty, R., Small, A., Solomon, H., Stephens, P., Stephens, Y., Stevens, C., Smith, R., Tarpey, P., Tofts, C., Varian, J., West, S., Widaa, S., Bamford, S., Butler, A., Dawson, E., Dicks, E., Edwards, K., Forbes, S., Greenman, C., Hinton, J., Menzies, A., Raine, K., Shepherd, R., Teague, J., Yates, A., Wooster, R., Futreal, A., Stratton, M. & Green, A. R., Mar 19 2005, In: Lancet. 365, 9464, p. 1054-1061 8 p.

      Research output: Contribution to journal › Article › peer-review

      3058 Scopus citations

    • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

      Stephens, P., Edkins, S., Davies, H., Greenman, C., Cox, C., Hunter, C., Bignell, G., Teague, J., Smith, R., Stevens, C., O'Meara, S., Parker, A., Tarpey, P., Avis, T., Barthorpe, A., Brackenbury, L., Buck, G., Butler, A., Clements, J., Cole, J., & 45 othersDicks, E., Edwards, K., Forbes, S., Gorton, M., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Shepherd, R., Small, A., Solomon, H., Stephens, Y., Tofts, C., Varian, J., Webb, A., West, S., Widaa, S., Yates, A., Brasseur, F., Cooper, C. S., Flanagan, A. M., Green, A., Knowles, M., Leung, S. Y., Looijenga, L. H. J., Malkowicz, B., Pierotti, M. A., Teh, B., Yuen, S. T., Nicholson, A. G., Lakhani, S., Easton, D. F., Weber, B. L., Stratton, M. R., Futreal, P. A. & Wooster, R., Jun 2005, In: Nature Genetics. 37, 6, p. 590-592 3 p.

      Research output: Contribution to journal › Article › peer-review

      292 Scopus citations

    • Somatic mutations in human cancer: Insights from resequencing the protein kinase gene family

      Futreal, P. A., Wooster, R. & Stratton, M. R., 2005, In: Cold Spring Harbor symposia on quantitative biology. 70, p. 43-49 7 p.

      Research output: Contribution to journal › Article › peer-review

      24 Scopus citations

    • Somatic mutations of the protein kinase gene family in human lung cancer

      Davies, H., Hunter, C., Smith, R., Stephens, P., Greenman, C., Bignell, G., Teague, J., Butler, A., Edkins, S., Stevens, C., Parker, A., O'Meara, S., Avis, T., Barthorpe, S., Brackenbury, L., Buck, G., Clements, J., Cole, J., Dicks, E., Edwards, K., & 44 othersForbes, S., Gorton, M., Gray, K., Halliday, K., Harrison, R., Hills, K., Hinton, J., Jones, D., Kosmidou, V., Laman, R., Lugg, R., Menzies, A., Perry, J., Petty, R., Raine, K., Shepherd, R., Small, A., Solomon, H., Stephens, Y., Tofts, C., Varian, J., Webb, A., West, S., Widaa, S., Yates, A., Brasseur, F., Cooper, C. S., Flanagan, A. M., Green, A., Knowles, M., Leung, S. Y., Looijenga, L. H. J., Malkowicz, B., Pierotti, M. A., Teh, B. T., Yuen, S. T., Lakhani, S. R., Easton, D. F., Weber, B. L., Goldstraw, P., Nicholson, A. G., Wooster, R., Stratton, M. R. & Futreal, P. A., Sep 1 2005, In: Cancer Research. 65, 17, p. 7591-7595 5 p.

      Research output: Contribution to journal › Article › peer-review

      397 Scopus citations
    • 2004

      1-Mb resolution array-based comparative genomic hybridization using a BAC clone set optimized for cancer gene analysis

      Greshock, J., Naylor, T. L., Margolin, A., Diskin, S., Cleaver, S. H., Futreal, P. A., deJong, P. J., Zhao, S., Liebman, M. & Weber, B. L., Jan 2004, In: Genome research. 14, 1, p. 179-187 9 p.

      Research output: Contribution to journal › Article › peer-review

      97 Scopus citations

    • A survey of RNA editing in human brain

      Blow, M., Futreal, A. P., Wooster, R. & Stratton, M. R., Dec 2004, In: Genome research. 14, 12, p. 2379-2387 9 p.

      Research output: Contribution to journal › Article › peer-review

      254 Scopus citations

    • High-resolution analysis of DNA copy number using oligonucleotide microarrays

      Bignell, G. R., Huang, J., Greshock, J., Watt, S., Butler, A., West, S., Grigorova, M., Jones, K. W., Wei, W., Stratton, M. R., Futreal, P. A., Weber, B., Shapero, M. H. & Wooster, R., Feb 2004, In: Genome research. 14, 2, p. 287-295 9 p.

      Research output: Contribution to journal › Article › peer-review

      309 Scopus citations