@article{03f55036feb141aa904272d63f848673,
title = "Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers",
abstract = "Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome.",
author = "Maser, {Richard S.} and Bhudipa Choudhury and Campbell, {Peter J.} and Bin Feng and Wong, {Kwok Kin} and Alexei Protopopov and Jennifer O'Neil and Alejandro Gutierrez and Elena Ivanova and Ilana Perna and Eric Lin and Vidya Mani and Shan Jiang and Kate McNamara and Sara Zaghlul and Sarah Edkins and Claire Stevens and Cameron Brennan and Martin, {Eric S.} and Ruprecht Wiedemeyer and Omar Kabbarah and Cristina Nogueira and Gavin Histen and Jon Aster and Marc Mansour and Veronique Duke and Letizia Foroni and Fielding, {Adele K.} and Goldstone, {Anthony H.} and Rowe, {Jacob M.} and Wang, {Yaoqi A.} and Look, {A. Thomas} and Stratton, {Michael R.} and Lynda Chin and Futreal, {P. Andrew} and DePinho, {Ronald A.}",
note = "Funding Information: Acknowledgements We thank Y. Zhang, A. Yu and K. Marmon for excellent mouse husbandry and care, and C. Greenman and E. Pleasance for helpful discussion on statistical analyses. R.S.M. was supported by the Damon Runyon Cancer Research Foundation. P.J.C. was supported by the Kay Kendall Leukaemia Fund, and B.C. is supported by a grant from GlaxoSmithKline. K.K.W. was supported by an NIH award. M.R.S. and P.A.F. are supported by the Wellcome Trust. L.C. and R.A.D. are supported by NIH grants, LeBow Fund to Cure Myeloma, the Chris Elliot Foundation, and the Center for Applied Cancer Science of the Belfer Institute for Innovative Cancer Science. R.A.D. is an Ellison Foundation for Medical Research Senior Scholar and an American Cancer Society Research Professor.",
year = "2007",
month = jun,
day = "21",
doi = "10.1038/nature05886",
language = "English (US)",
volume = "447",
pages = "966--971",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7147",
}