Research output per year
Research output per year
- 32 results
Search results
-
2024
Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy
Lu, D., Chen, J., Qin, L., Bijou, I., Yi, P., Li, F., Song, X., MacKenzie, K. R., Yu, X., Yang, B., Roy Chowdhury, S., Korp, J. D., O’Malley, B. W., Lonard, D. M. & Wang, J., Apr 11 2024, In: Journal of Medicinal Chemistry. 67, 7, p. 5333-5350 18 p.Research output: Contribution to journal › Article › peer-review
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2023
TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer
Singh, R., Meng, H., Shen, T., Lumahan, L. E. V., Nguyen, S., Shen, H., Dasgupta, S., Qin, L., Karri, D., Zhu, B., Yang, F., Coarfa, C., Malley, B. W. O. & Yi, P., May 16 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 20, e2218229120.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2022
Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway
Martinez, J. D., Mo, Q., Xu, Y., Qin, L., Li, Y. & Xu, J., 2022, In: International journal of biological sciences. 18, 1, p. 229-241 13 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Reply to: Target expression is a relevant factor in synthetic lethal screens
Gilad, Y., Eliaz, Y., Yu, Y., Dean, A. M., Han, S. J., Qin, L., O’Malley, B. W. & Lonard, D. M., Dec 2022, In: Communications Biology. 5, 1, 836.Research output: Contribution to journal › Letter › peer-review
Open Access -
2021
A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells
Gilad, Y., Eliaz, Y., Yu, Y., Dean, A. M., Han, S. J., Qin, L., O’Malley, B. W. & Lonard, D. M., Dec 2021, In: Communications Biology. 4, 1, 399.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Development of improved SRC-3 inhibitors as breast cancer therapeutic agents
Qin, L., Chen, J., Lu, D., Jain, P., Yu, Y., Cardenas, D., Peng, X., Yu, X., Xu, J., Wang, J., O’Malley, B. W. & Lonard, D. M., Oct 2021, In: Endocrine-related cancer. 28, 10, p. 657-670 14 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2017
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells
Wang, Z., Zhang, F., He, J., Wu, P., Tay, L. W. R., Cai, M., Nian, W., Weng, Y., Qin, L., Chang, J. T., McIntire, L. B., Di Paolo, G., Xu, J., Peng, J. & Du, G., Oct 23 2017, In: Developmental cell. 43, 2, p. 186-197.e7Research output: Contribution to journal › Article › peer-review
Open Access54 Scopus citations -
Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer
Wu, H., Bi, J., Peng, Y., Huo, L., Yu, X., Yang, Z., Zhou, Y., Qin, L., Xu, Y., Liao, L., Xie, Y., Conneely, O. M., Jonkers, J. & Xu, J., 2017, In: Oncotarget. 8, 33, p. 54364-54377 14 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
The histone demethylase Kdm 3a is required for normal epithelial proliferation ductal elongation and tumor growth in the mouse mammary gland
Qin, L., Xu, Y., Yu, X., Toneff, M. J., Li, D., Liao, L., Martinez, J. D., Li, Y. & Xu, J., Oct 17 2017, In: Oncotarget. 8, 49, p. 84761-84775 15 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression
Xu, Y., Qin, L., Sun, T., Wu, H., He, T., Yang, Z., Mo, Q., Liao, L. & Xu, J., Feb 23 2017, In: Oncogene. 36, 8, p. 1157-1166 10 p.Research output: Contribution to journal › Article › peer-review
Open Access124 Scopus citations -
2015
Knockout of SRC-1 and SRC-3 in mice decreases cardiomyocyte proliferation and causes a noncompaction cardiomyopathy phenotype
Chen, X., Qin, L., Liu, Z., Liao, L., Martin, J. F. & Xu, J., Jul 15 2015, In: International journal of biological sciences. 11, 9, p. 1056-1072 17 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription
Qin, L., Xu, Y., Xu, Y., Ma, G., Liao, L., Wu, Y., Li, Y., Wang, X., Wang, X., Jiang, J., Wang, J. & Xu, J., 2015, In: Oncotarget. 6, 27, p. 23890-23904 15 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug
Song, X., Zhang, C., Zhao, M., Chen, H., Liu, X., Chen, J., Lonard, D. M., Qin, L., Xu, J., Wang, X., Li, F., O'Malley, B. W. & Wang, J., Oct 2 2015, In: PloS one. 10, 10, e0140011.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2014
Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis
Walsh, C. A., Bolger, J. C., Byrne, C., Cocchiglia, S., Hao, Y., Fagan, A., Qin, L., Cahalin, A., McCartan, D., McIlroy, M., O'Gaora, P., Xu, J., Hill, A. D. & Young, L. S., Jan 5 2014, In: Cancer Research. 74, 9, p. 2533-2544 12 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
LncRNA directs cooperative epigenetic regulation downstream of chemokine signals
Xing, Z., Lin, A., Li, C., Liang, K., Wang, S., Liu, Y., Park, P. K., Qin, L., Wei, Y., Hawke, D. H., Hung, M. C., Lin, C. & Yang, L., Nov 20 2014, In: Cell. 159, 5, p. 1110-1125 16 p.Research output: Contribution to journal › Article › peer-review
370 Scopus citations -
NCOA1 directly targets M-CSF1 expression to promote breast cancer metastasis
Qin, L., Wu, Y. L., Toneff, M. J., Li, D., Liao, L., Gao, X., Bane, F. T., Tien, J. C. Y., Xu, Y., Feng, Z., Yang, Z., Xu, Y., Theissen, S. M., Li, Y., Young, L. & Xu, J., Jul 1 2014, In: Cancer Research. 74, 13, p. 3477-3488 12 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
SRC-1 and twist1 expression positively correlates with a poor prognosis in human breast cancer
Xu, Y., Hu, B., Qin, L., Zhao, L., Wang, Q., Wang, Q., Xu, Y. & Jiang, J., Mar 15 2014, In: International journal of biological sciences. 10, 4, p. 396-403 8 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
2013
Inducible knockout of twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting twist1 as a preferential cancer target
Xu, Y., Xu, Y., Liao, L., Zhou, N., Theissen, S. M., Liao, X. H., Nguyen, H., Ludwig, T., Qin, L., Martinez, J. D., Jiang, J. & Xu, J., Oct 2013, In: American Journal of Pathology. 183, 4, p. 1281-1292 12 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2012
Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer
McCartan, D., Bolger, J. C., Fagan, A., Byrne, C., Hao, Y., Qin, L., McIlroy, M., Xu, J., Hill, A. D., Ó Gaora, P. & Young, L. S., Jan 1 2012, In: Cancer Research. 72, 1, p. 220-229 10 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control
Chen, L. Y., Zhang, Y., Zhang, Q., Li, H., Luo, Z., Fang, H., Kim, S. H., Qin, L., Yotnda, P., Xu, J., Tu, B. P., Bai, Y. & Songyang, Z., Sep 28 2012, In: Molecular cell. 47, 6, p. 839-850 12 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Scopus citations -
Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner
Zhou, J., Qin, L., Tien, J. C. Y., Gao, L., Chen, X., Wang, F., Hsieh, J. T. & Xu, J., May 18 2012, In: Journal of Biological Chemistry. 287, 21, p. 17248-17256 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
The function of steroid receptor coactivator-1 in normal tissues and cancer
Walsh, C. A., Qin, L., Tien, J. C. Y., Young, L. S. & Xu, J., Mar 7 2012, In: International journal of biological sciences. 8, 4, p. 470-485 16 p.Research output: Contribution to journal › Review article › peer-review
Open Access81 Scopus citations -
2011
Steroid receptor coactivator-1 upregulates integrin α5 expression to promote breast cancer cell adhesion and migration
Qin, L., Chen, X., Wu, Y., Feng, Z., He, T., Wang, L., Liao, L. & Xu, J., Mar 1 2011, In: Cancer Research. 71, 5, p. 1742-1751 10 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
Fu, J., Qin, L., He, T., Qin, J., Hong, J., Wong, J., Liao, L. & Xu, J., Feb 2011, In: Cell research. 21, 2, p. 275-289 15 p.Research output: Contribution to journal › Article › peer-review
Open Access233 Scopus citations -
2010
Maspin regulates endothelial cell adhesion and migration through an integrin signaling pathway
Qin, L. & Zhang, M., Oct 15 2010, In: Journal of Biological Chemistry. 285, 42, p. 32360-32369 10 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
2009
The steroid receptor coactivator-1 regulates Twist expression and promotes breast cancer metastasis
Qin, L., Liu, Z., Chen, H. & Xu, J., May 1 2009, In: Cancer Research. 69, 9, p. 3819-3827 9 p.Research output: Contribution to journal › Article › peer-review
Open Access128 Scopus citations -
2008
The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression
Qin, L., Liao, L., Redmond, A., Young, L., Yuan, Y., Chen, H., O'Malley, B. W. & Xu, J., Oct 2008, In: Molecular and cellular biology. 28, 19, p. 5937-5950 14 p.Research output: Contribution to journal › Article › peer-review
169 Scopus citations -
2007
Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression
Yuan, Y., Qin, L., Liu, D., Wu, R. C., Mussi, P., Zhou, S., Songyang, Z. & Xu, J., Sep 1 2007, In: Cancer Research. 67, 17, p. 8032-8042 11 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2005
Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy
Bai, S. X., Wang, Y. L., Qin, L., Xiao, Z. J., Herva, R. & Piao, Y. S., Jan 2005, In: Reproduction. 129, 1, p. 103-113 11 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
2003
Expression of integrins extracellular matrix proteins at the maternal-fetal interface during tubal implantation
Qin, L., Wang, Y. L., Bai, S. X., Xiao, Z. J., Herva, R. & Piao, Y. S., Sep 1 2003, In: Reproduction. 126, 3, p. 383-391 9 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
Expression of P450 aromatase and 17β-hydroxysteroid dehydrogenase type 1 at fetal-maternal interface during tubal pregnancy
Li, Y., Qin, L., Xiao, Z. J., Wang, Y. L., Herva, R., Leng, J. H., Lang, J. H., Isomaa, V. & Piao, Y. S., Dec 2003, In: Journal of Steroid Biochemistry and Molecular Biology. 87, 4-5, p. 241-246 6 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Temporal and spatial expression of integrins and their extracellular matrix ligands at the maternal-fetal interface in the rhesus monkey during pregnancy
Qin, L., Wang, Y. L., Bai, S. X., Ji, S. H., Qiu, W., Tang, S. & Piao, Y. S., Aug 1 2003, In: Biology of reproduction. 69, 2, p. 563-571 9 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations