Wen-Bin Tsai

2022

Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

Schwabkey, Z. I., Wiesnoski, D. H., Chang, C. C., Tsai, W. B., Pham, D., Ahmed, S. S., Hayase, T., Ortega Turrubiates, M. R., El-Himri, R. K., Sanchez, C. A., Hayase, E., Frenk Oquendo, A. C., Miyama, T., Halsey, T. M., Heckel, B. E., Brown, A. N., Jin, Y., Raybaud, M., Prasad, R., Flores, I., & 39 othersMcDaniel, L., Chapa, V., Lorenzi, P. L., Warmoes, M. O., Tan, L., Swennes, A. G., Fowler, S., Conner, M., McHugh, K., Graf, T., Jensen, V. B., Peterson, C. B., Do, K. A., Zhang, L., Shi, Y., Wang, Y., Galloway-Pena, J. R., Okhuysen, P. C., Daniel-MacDougall, C. R., Shono, Y., da Silva, M. B., Peled, J. U., van den Brink, M. R. M., Ajami, N., Wargo, J. A., Reddy, P., Valdivia, R. H., Davey, L., Rondon, G., Srour, S. A., Mehta, R. S., Alousi, A. M., Shpall, E. J., Champlin, R. E., Shelburne, S. A., Molldrem, J. J., Jamal, M. A., Karmouch, J. L. & Jenq, R. R., Nov 16 2022, In: Science translational medicine. 14, 671, eabo3445.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease

Hayase, E., Hayase, T., Jamal, M. A., Miyama, T., Chang, C. C., Ortega, M. R., Ahmed, S. S., Karmouch, J. L., Sanchez, C. A., Brown, A. N., El-Himri, R. K., Flores, I. I., McDaniel, L. K., Pham, D., Halsey, T., Frenk, A. C., Chapa, V. A., Heckel, B. E., Jin, Y., Tsai, W. B., & 20 othersPrasad, R., Tan, L., Veillon, L., Ajami, N. J., Wargo, J. A., Galloway-Peña, J., Shelburne, S., Chemaly, R. F., Davey, L., Glowacki, R. W. P., Liu, C., Rondon, G., Alousi, A. M., Molldrem, J. J., Champlin, R. E., Shpall, E. J., Valdivia, R. H., Martens, E. C., Lorenzi, P. L. & Jenq, R. R., Sep 29 2022, In: Cell. 185, 20, p. 3705-3719.e14

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2021

Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3

Chung, Y. M., Khan, P. P., Wang, H., Tsai, W. B., Qiao, Y., Yu, B., Larrick, J. W. & Hu, M. C. T., Dec 2021, In: Journal for immunotherapy of cancer. 9, 12, e002772.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2020

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

Kuo, M. T., Long, Y., Tsai, W. B., Li, Y. Y., Chen, H. H. W., Feun, L. G. & Savaraj, N., Feb 2020, In: Translational Oncology. 13, 2, p. 355-364 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2017

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

Long, Y., Tsai, W. B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M. C., Chen, H. H. W. & Kuo, M. T., Mar 1 2017, In: Cancer Letters. 388, p. 54-63 10 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Tsai, W. B., Long, Y., Chang, J. T., Savaraj, N., Feun, L. G., Jung, M., Chen, H. H. W. & Kuo, M. T., Dec 1 2017, In: Scientific reports. 7, 1, 10814.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2016

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation

Long, Y., Tsai, W. B., Chang, J. T., Estecio, M., Wangpaichitr, M., Savaraj, N., Feun, L. G., Chen, H. W. & Kuo, M. T., 2016, In: Oncotarget. 7, 50, p. 82658-82670 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents

Tsai, W. B., Long, Y., Park, J. R., Chang, J. T., Liu, H., Rodriguez-Canales, J., Savaraj, N., Feun, L. G., Davies, M. A., Wistuba, I. I. & Kuo, M. T., Mar 31 2016, In: Oncogene. 35, 13, p. 1632-1642 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2013

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

Long, Y., Tsai, W. B., Wangpaichitr, M., Tsukamoto, T., Savaraj, N., Feun, L. G. & Kuo, M. T., Nov 2013, In: Molecular cancer therapeutics. 12, 11, p. 2581-2590 10 p.

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

2012

Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells

Tsai, W. B., Aiba, I., Long, Y., Lin, H. K., Feun, L., Savaraj, N. & Kuo, M. T., May 15 2012, In: Cancer Research. 72, 10, p. 2622-2633 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

163 Scopus citations

FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

Chung, Y. M., Park, S. H., Tsai, W. B., Wang, S. Y., Ikeda, M. A., Berek, J. S., Chen, D. J. & Hu, M. C. T., 2012, In: Nature communications. 3, 1000.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Mechanistic basis for overcoming platinum resistance using copper chelating agents

Liang, Z. D., Long, Y., Tsai, W. B., Fu, S., Kurzrock, R., Gagea-Iurascu, M., Zhang, F., Chen, H. H. W., Hennessy, B. T., Mills, G. B., Savaraj, N. & Kuo, M. T., Nov 2012, In: Molecular cancer therapeutics. 11, 11, p. 2483-2494 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Specificity protein 1 (Sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression

Liang, Z. D., Tsai, W. B., Lee, M. Y., Savaraj, N. & Kuo, M. T., Mar 2012, In: Molecular Pharmacology. 81, 3, p. 455-464 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

2010

Inhibition of FOXO3 tumor suppressor function by βTrCP1 through ubiquitin-mediated degradation in a tumor mouse model

Tsai, W. B., Chung, Y. M., Zou, Y., Park, S. H., Xu, Z., Nakayama, K., Lin, S. H. & Hu, M. C. T., 2010, In: PloS one. 5, 7, e11171.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2009

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1α/Sp4

Tsai, W. B., Aiba, I., Lee, S. Y., Feun, L., Savaraj, N. & Kuo, M. T., Dec 2009, In: Molecular cancer therapeutics. 8, 12, p. 3223-3233 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

104 Scopus citations

2008

A 45-kDa ErbB3 secreted by prostate cancer cells promotes bone formation

Lin, S. H., Cheng, C. J., Lee, Y. C., Ye, X., Tsai, W. W., Kim, J., Pasqualini, R., Arap, W., Navone, N. M., Tu, S. M., Hu, M., Yu-Lee, L. Y. & Logothetis, C. J., Sep 4 2008, In: Oncogene. 27, 39, p. 5195-5203 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis

Zou, Y., Tsai, W. B., Cheng, C. J., Hsu, C., Chung, Y. M., Li, P. C., Lin, S. H. & Hu, M. C. T., Feb 29 2008, In: Breast Cancer Research. 10, 1, R21.

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Functional interaction between FOXO3a and ATM regulates DNA damage response

Tsai, W. B., Chung, Y. M., Takahashi, Y., Xu, Z. & Hu, M. C. T., 2008, In: Nature cell biology. 10, 4, p. 460-467 8 p.

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

2004

Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53

Li, Z., Day, C. P., Yang, J. Y., Tsai, W. B., Lozano, G., Shih, H. M. & Hung, M. C., Dec 15 2004, In: Cancer Research. 64, 24, p. 9080-9085 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Wen-Bin Tsai

Research output

Search results