TY - JOUR
T1 - 1 Protein methyltransferases
T2 - Their distribution among the five structural classes of adomet-dependent methyltransferases
AU - Schubert, Heidi L.
AU - Blumenthal, Robert M.
AU - Cheng, Xiaodong
N1 - Funding Information:
H.L.S. was supported by a grant from NIH (GM56775), R.M.B. was supported by a grant from the U.S. NSF (MCB-05 16692), and X.C. was supported by a grant from NIH (GM068680) and the Georgia Research Alliance.
PY - 2006
Y1 - 2006
N2 - S-adenosyl-l-methionine (AdoMet) dependent methyltransferases (MTases) are involved in biosynthesis, signal transduction, protein repair, chromatin regulation, and gene silencing. Five different structural folds (designated I through V) have been described that bind AdoMet and catalyze methyltransfer to diverse substrates, although the great majority of known MTases have the Class I fold. Even within a particular MTase class the amino-acid sequence similarity can be as low as 10%. Thus, the structural and catalytic requirements for methyltransfer from AdoMet appear to be remarkably flexible. MTases that act on protein substrates have been found to date among three of the five structural classes (I, the classical fold; III, the corrin MTase fold; and V, the SET fold). "There are many paths to the top of the mountain, but the view is always the same."-Chinese proverb The Columbia World of Quotations, New York, Columbia University Press, 1996.
AB - S-adenosyl-l-methionine (AdoMet) dependent methyltransferases (MTases) are involved in biosynthesis, signal transduction, protein repair, chromatin regulation, and gene silencing. Five different structural folds (designated I through V) have been described that bind AdoMet and catalyze methyltransfer to diverse substrates, although the great majority of known MTases have the Class I fold. Even within a particular MTase class the amino-acid sequence similarity can be as low as 10%. Thus, the structural and catalytic requirements for methyltransfer from AdoMet appear to be remarkably flexible. MTases that act on protein substrates have been found to date among three of the five structural classes (I, the classical fold; III, the corrin MTase fold; and V, the SET fold). "There are many paths to the top of the mountain, but the view is always the same."-Chinese proverb The Columbia World of Quotations, New York, Columbia University Press, 1996.
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U2 - 10.1016/S1874-6047(06)80003-X
DO - 10.1016/S1874-6047(06)80003-X
M3 - Article
C2 - 26718035
AN - SCOPUS:77956681314
SN - 1874-6047
VL - 24
SP - 3
EP - 28
JO - Enzymes
JF - Enzymes
IS - C
ER -