• 6767 Bertner Ave, Mitchell Basic Science Research Building

    77030 Houston

    United States

  • 17189 Citations
  • 69 h-Index
1990 …2019
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Fingerprint Dive into the research topics where Xiaodong Cheng is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 18 Similar Profiles
Methyltransferases Medicine & Life Sciences
DNA Medicine & Life Sciences
Methylation Medicine & Life Sciences
DNA Methylation Medicine & Life Sciences
Histones Medicine & Life Sciences
Lysine Medicine & Life Sciences
Cytosine Medicine & Life Sciences
Histone-Lysine N-Methyltransferase Medicine & Life Sciences

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Research Output 1990 2019

Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure

Milite, C., Feoli, A., Horton, J. R., Rescigno, D., Cipriano, A., Pisapia, V., Viviano, M., Pepe, G., Amendola, G., Novellino, E., Cosconati, S., Cheng, X., Castellano, S. & Sbardella, G., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2666-2689 24 p.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
Methyltransferases
Artificial Membranes
Permeability
Proteins

Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes

Zoeller, E. L., Pedro, B., Konen, J., Dwivedi, B., Rupji, M., Sundararaman, N., Wang, L., Horton, J. R., Zhong, C., Barwick, B. G., Cheng, X., Martinez, E. D., Torres, M. P., Kowalski, J., Marcus, A. I. & Vertino, P. M., Oct 9 2019, In : Journal of cell science. 132, 19

Research output: Contribution to journalArticle

Open Access
Genetic Heterogeneity
Phenotype
Neoplasms
Mutation
Non-Small Cell Lung Carcinoma

Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112

Woodcock, C. B., Yu, D., Zhang, X. & Cheng, X., Dec 1 2019, In : Cell Discovery. 5, 1, 50.

Research output: Contribution to journalLetter

Open Access
Protein Methyltransferases
DNA
In Vitro Techniques
11 Citations (Scopus)

SETD3 is an actin histidine methyltransferase that prevents primary dystocia

Wilkinson, A. W., Diep, J., Dai, S., Liu, S., Ooi, Y. S., Song, D., Li, T. M., Horton, J. R., Zhang, X., Liu, C., Trivedi, D. V., Ruppel, K. M., Vilches-Moure, J. G., Casey, K. M., Mak, J., Cowan, T., Elias, J. E., Nagamine, C. M., Spudich, J. A., Cheng, X. & 2 others, Carette, J. E. & Gozani, O., Jan 17 2019, In : Nature. 565, 7739, p. 372-376 5 p.

Research output: Contribution to journalLetter

Dystocia
Methyltransferases
Histidine
Methylation
Actins

Structural basis for effects of CpA modifications on C/EBP binding of DNA

Yang, J., Horton, J. R., Wang, D., Ren, R., Li, J., Sun, D., Huang, Y., Zhang, X., Blumenthal, R. M. & Cheng, X., Jan 1 2019, In : Nucleic acids research. 47, 4, p. 1774-1785 12 p.

Research output: Contribution to journalArticle

Open Access
CCAAT-Enhancer-Binding Proteins
Protein Binding
Basic-Leucine Zipper Transcription Factors
DNA
Methylation