A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases

Yiqun Zhang; Lixing Yang; Melanie Kucherlapati; Fengju Chen; Angela Hadjipanayis; Angeliki Pantazi; Christopher A. Bristow; Eunjung A. Lee; Harshad S. Mahadeshwar; Jiabin Tang; Jianhua Zhang; Sahil Seth; Semin Lee; Xiaojia Ren; Xingzhi Song; Huandong Sun; Jonathan Seidman; Lovelace J. Luquette; Ruibin Xi; Lynda Chin; Alexei Protopopov; Wei Li; Peter J. Park; Raju Kucherlapati; Chad J. Creighton

doi:10.1016/j.celrep.2018.06.025

A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases

Yiqun Zhang, Lixing Yang, Melanie Kucherlapati, Fengju Chen, Angela Hadjipanayis, Angeliki Pantazi, Christopher A. Bristow, Eunjung A. Lee, Harshad S. Mahadeshwar, Jiabin Tang, Jianhua Zhang, Sahil Seth, Semin Lee, Xiaojia Ren, Xingzhi Song, Huandong Sun, Jonathan Seidman, Lovelace J. Luquette, Ruibin Xi, Lynda ChinAlexei Protopopov, Wei Li, Peter J. Park, Raju Kucherlapati, Chad J. Creighton

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61 Scopus citations

Abstract

Zhang et al. analyzed over 1,400 cancers by high- or low-pass whole-genome sequencing, focusing on patterns of structural variation. They saw a widespread impact of somatic structural variants on gene expression patterns, independent of copy-number alterations, involving key oncogenes and tumor suppressor genes.

Original language	English (US)
Pages (from-to)	515-527
Number of pages	13
Journal	Cell Reports
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2018.06.025
State	Published - Jul 10 2018

Keywords

TCGA
cancer
genomic rearrangement
pan-cancer
structural variation
whole genome sequencing

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.06.025

Cite this

Zhang, Y., Yang, L., Kucherlapati, M., Chen, F., Hadjipanayis, A., Pantazi, A., Bristow, C. A., Lee, E. A., Mahadeshwar, H. S., Tang, J., Zhang, J., Seth, S., Lee, S., Ren, X., Song, X., Sun, H., Seidman, J., Luquette, L. J., Xi, R., ... Creighton, C. J. (2018). A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases. Cell Reports, 24(2), 515-527. https://doi.org/10.1016/j.celrep.2018.06.025

Zhang, Y, Yang, L, Kucherlapati, M, Chen, F, Hadjipanayis, A, Pantazi, A, Bristow, CA, Lee, EA, Mahadeshwar, HS, Tang, J, Zhang, J, Seth, S, Lee, S, Ren, X, Song, X , Sun, H, Seidman, J, Luquette, LJ, Xi, R, Chin, L, Protopopov, A, Li, W, Park, PJ, Kucherlapati, R & Creighton, CJ 2018, 'A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases', Cell Reports, vol. 24, no. 2, pp. 515-527. https://doi.org/10.1016/j.celrep.2018.06.025

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title = "A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases",

abstract = "Zhang et al. analyzed over 1,400 cancers by high- or low-pass whole-genome sequencing, focusing on patterns of structural variation. They saw a widespread impact of somatic structural variants on gene expression patterns, independent of copy-number alterations, involving key oncogenes and tumor suppressor genes.",

keywords = "TCGA, cancer, genomic rearrangement, pan-cancer, structural variation, whole genome sequencing",

author = "Yiqun Zhang and Lixing Yang and Melanie Kucherlapati and Fengju Chen and Angela Hadjipanayis and Angeliki Pantazi and Bristow, {Christopher A.} and Lee, {Eunjung A.} and Mahadeshwar, {Harshad S.} and Jiabin Tang and Jianhua Zhang and Sahil Seth and Semin Lee and Xiaojia Ren and Xingzhi Song and Huandong Sun and Jonathan Seidman and Luquette, {Lovelace J.} and Ruibin Xi and Lynda Chin and Alexei Protopopov and Wei Li and Park, {Peter J.} and Raju Kucherlapati and Creighton, {Chad J.}",

note = "Funding Information: This work was supported by NIH grant P30CA125123 (to C.J.C.) and the Cancer Prevention and Research Institute of Texas (CPRIT) grant RP120713 C2 (to C.J.C.). ",

year = "2018",

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doi = "10.1016/j.celrep.2018.06.025",

language = "English (US)",

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T1 - A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases

AU - Zhang, Yiqun

AU - Yang, Lixing

AU - Kucherlapati, Melanie

AU - Chen, Fengju

AU - Hadjipanayis, Angela

AU - Pantazi, Angeliki

AU - Bristow, Christopher A.

AU - Lee, Eunjung A.

AU - Mahadeshwar, Harshad S.

AU - Tang, Jiabin

AU - Zhang, Jianhua

AU - Seth, Sahil

AU - Lee, Semin

AU - Ren, Xiaojia

AU - Song, Xingzhi

AU - Sun, Huandong

AU - Seidman, Jonathan

AU - Luquette, Lovelace J.

AU - Xi, Ruibin

AU - Chin, Lynda

AU - Protopopov, Alexei

AU - Li, Wei

AU - Park, Peter J.

AU - Kucherlapati, Raju

AU - Creighton, Chad J.

N1 - Funding Information: This work was supported by NIH grant P30CA125123 (to C.J.C.) and the Cancer Prevention and Research Institute of Texas (CPRIT) grant RP120713 C2 (to C.J.C.).

PY - 2018/7/10

Y1 - 2018/7/10

N2 - Zhang et al. analyzed over 1,400 cancers by high- or low-pass whole-genome sequencing, focusing on patterns of structural variation. They saw a widespread impact of somatic structural variants on gene expression patterns, independent of copy-number alterations, involving key oncogenes and tumor suppressor genes.

AB - Zhang et al. analyzed over 1,400 cancers by high- or low-pass whole-genome sequencing, focusing on patterns of structural variation. They saw a widespread impact of somatic structural variants on gene expression patterns, independent of copy-number alterations, involving key oncogenes and tumor suppressor genes.

KW - TCGA

KW - cancer

KW - genomic rearrangement

KW - pan-cancer

KW - structural variation

KW - whole genome sequencing

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A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases

Abstract

Keywords

ASJC Scopus subject areas

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