A systems biology approach to personalizing therapeutic combinations

Lawrence N. Kwong; Timothy P. Heffernan; Lynda Chin

doi:10.1158/2159-8290.CD-13-0394

A systems biology approach to personalizing therapeutic combinations

Lawrence N. Kwong, Timothy P. Heffernan, Lynda Chin

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.

Original language	English (US)
Pages (from-to)	1339-1344
Number of pages	6
Journal	Cancer discovery
Volume	3
Issue number	12
DOIs	https://doi.org/10.1158/2159-8290.CD-13-0394
State	Published - Dec 2013

ASJC Scopus subject areas

Oncology

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10.1158/2159-8290.CD-13-0394

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title = "A systems biology approach to personalizing therapeutic combinations",

abstract = "The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.",

author = "Kwong, {Lawrence N.} and Heffernan, {Timothy P.} and Lynda Chin",

year = "2013",

month = dec,

doi = "10.1158/2159-8290.CD-13-0394",

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journal = "Cancer discovery",

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AU - Kwong, Lawrence N.

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VL - 3

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JO - Cancer discovery

JF - Cancer discovery

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A systems biology approach to personalizing therapeutic combinations

Abstract

ASJC Scopus subject areas

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