ADP-Ribosylation: Activation, Recognition, and Removal

Nan Li; Junjie Chen

doi:10.14348/molcells.2014.2245

ADP-Ribosylation: Activation, Recognition, and Removal

Nan Li, Junjie Chen

Research output: Contribution to journal › Short survey › peer-review

41 Scopus citations

Abstract

ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.

Original language	English (US)
Pages (from-to)	9-16
Number of pages	8
Journal	Molecules and cells
Volume	37
Issue number	1
DOIs	https://doi.org/10.14348/molcells.2014.2245
State	Published - Jan 2014

Keywords

ADP-Ribosylation
PAR recognition domain
PARG
PARP

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.14348/molcells.2014.2245

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abstract = "ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.",

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author = "Nan Li and Junjie Chen",

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AU - Chen, Junjie

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AB - ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.

KW - ADP-Ribosylation

KW - PAR recognition domain

KW - PARG

KW - PARP

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ER -

ADP-Ribosylation: Activation, Recognition, and Removal

Abstract

Keywords

ASJC Scopus subject areas

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