TY - JOUR
T1 - Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress
AU - Leung, Justin Wai Chung
AU - Ghosal, Gargi
AU - Wang, Wenqi
AU - Shen, Xi
AU - Wang, Jiadong
AU - Li, Lei
AU - Chen, Junjie
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress. ATRX is recruited to sites of DNA damage, required for efficient checkpoint activation and faithful replication restart. In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability.
AB - Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress. ATRX is recruited to sites of DNA damage, required for efficient checkpoint activation and faithful replication restart. In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability.
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U2 - 10.1074/jbc.M112.411603
DO - 10.1074/jbc.M112.411603
M3 - Article
C2 - 23329831
AN - SCOPUS:84874763212
SN - 0021-9258
VL - 288
SP - 6342
EP - 6350
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 9
ER -