@article{9fe16fc9d50c4f34ad25d3e34768eaec,
title = "An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3",
abstract = "Documented interactions among members of the Myc superfamily support a yin-yang model for the regulation of Myc-responsive genes in which transactivation-competent Myc-Max heterodimers are opposed by repressive Mxi1-Max or Mad-Max complexes. Analysis of mouse mxi1 has led to the identification of two mxi1 transcript forms possessing open reading frames that differ in their capacity to encode a short amino-terminal α-helical domain. The presence of this segment dramatically augments the suppressive potential of Mxil and allows for association with a mammalian protein that is structurally homologous to the yeast transcriptional repressor SIN3. These findings provide a mechanistic basis for the antagonistic actions of Mxi1 on Myc activity that appears to be mediated in part through the recruitment of a putative transcriptional repressor.",
author = "Nicole Schreiber-Agus and Lynda Chin and Ken Chen and Richard Torres and Govinda Rao and Peter Guida and Skoultchi, {Arthur I.} and DePinho, {Ronald A.}",
note = "Funding Information: Correspondence should be addressed to R. A. D. The authors thank Drs. Bob Eisenman and Don Ayer for discussing unpublished data on roSin3, Drs. George Yancopoulos and Scott Mellis for helpful comments, Jolaine Lauridsen for assistance in manuscript preparation, and Joe DePinho for graphic illustration. N. S.-A. is supported by National Institutes of Health (NIH) training grants T32GM07128 and 2T32AG00194. K. C. was supported by March of Dimes research grant 1-FY93-0746. R. T. was supported by NIH training grant RT32CA-09173. G. R. and A. I. S. are supported by NIH grant 5R37CA16368. R. A. D. is a recipient of an American Heart Association Investigator Award and is supported by NIH grants RO1-EY09300 and HD28317. Support was also derived from American Cancer Society basic research grant DB117 and National Cancer Institute Cancer Center grant 2P30CA13330.",
year = "1995",
month = mar,
day = "10",
doi = "10.1016/0092-8674(95)90356-9",
language = "English (US)",
volume = "80",
pages = "777--786",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "5",
}