Abstract
The remarkably coordinated nature of the DNA damage response pathway relies on numerous mechanisms that facilitate the assembly of checkpoint and repair factors at DNA breaks. Post-translational modifications on and around chromatin have critical roles in allowing the timely and sequential assembly of DNA damage responsive elements at the vicinity of DNA breaks. Notably, recent advances in forward genetics and proteomics-based approaches have enabled the identification of novel components within the DNA damage response pathway, providing a more comprehensive picture of the molecular network that assists in the detection and propagation of DNA damage signals.
Original language | English (US) |
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Pages (from-to) | 101-108 |
Number of pages | 8 |
Journal | Trends in Biochemical Sciences |
Volume | 35 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2010 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology