Central venous catheter-associated Nocardia bacteremia in cancer patients

Fadi Al Akhrass; Ray Hachem; Jamal A. Mohamed; Jeffrey Tarrand; Dimitrios P. Kontoyiannis; Jyotsna Chandra; Mahmoud Ghannoum; Souha Haydoura; Ann Marie Chaftari; Issam Raad

doi:10.3201/eid1709.101810

Central venous catheter-associated Nocardia bacteremia in cancer patients

Fadi Al Akhrass, Ray Hachem, Jamal A. Mohamed, Jeffrey Tarrand, Dimitrios P. Kontoyiannis, Jyotsna Chandra, Mahmoud Ghannoum, Souha Haydoura, Ann Marie Chaftari, Issam Raad

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a disseminated infection. N. nova complex was the leading cause of bacteremia. Nocardia promoted heavy biofi lm formation on the surface of central venous catheter segments tested in an in vitro biofi lm model. Trimethoprimand minocycline-based lock solutions had potent in vitro activity against biofi lm growth. Patients with Nocardia central venous catheter-associated bloodstream infections responded well to catheter removal and antimicrobial drug therapy, whereas those with disseminated bacteremia had poor prognoses.

Original language	English (US)
Pages (from-to)	1651-1658
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	17
Issue number	9
DOIs	https://doi.org/10.3201/eid1709.101810
State	Published - Sep 2011

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Central venous catheter-associated Nocardia bacteremia in cancer patients",

abstract = "Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a disseminated infection. N. nova complex was the leading cause of bacteremia. Nocardia promoted heavy biofi lm formation on the surface of central venous catheter segments tested in an in vitro biofi lm model. Trimethoprimand minocycline-based lock solutions had potent in vitro activity against biofi lm growth. Patients with Nocardia central venous catheter-associated bloodstream infections responded well to catheter removal and antimicrobial drug therapy, whereas those with disseminated bacteremia had poor prognoses.",

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AU - Hachem, Ray

AU - Mohamed, Jamal A.

AU - Tarrand, Jeffrey

AU - Kontoyiannis, Dimitrios P.

AU - Chandra, Jyotsna

AU - Ghannoum, Mahmoud

AU - Haydoura, Souha

AU - Chaftari, Ann Marie

AU - Raad, Issam

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AB - Central venous catheters, often needed by cancer patients, can be the source of Nocardia bacteremia. We evaluated the clinical characteristics and outcomes of 17 cancer patients with Nocardia bacteremia. For 10 patients, the bacteremia was associated with the catheter; for the other 7, it was a disseminated infection. N. nova complex was the leading cause of bacteremia. Nocardia promoted heavy biofi lm formation on the surface of central venous catheter segments tested in an in vitro biofi lm model. Trimethoprimand minocycline-based lock solutions had potent in vitro activity against biofi lm growth. Patients with Nocardia central venous catheter-associated bloodstream infections responded well to catheter removal and antimicrobial drug therapy, whereas those with disseminated bacteremia had poor prognoses.

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Central venous catheter-associated Nocardia bacteremia in cancer patients

Abstract

ASJC Scopus subject areas

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