Claspin, a regulator of Chk1 in DNA replication stress pathway

Claudia C.S. Chini; Junjie Chen

doi:10.1016/j.dnarep.2004.03.001

Claspin, a regulator of Chk1 in DNA replication stress pathway

Claudia C.S. Chini, Junjie Chen

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

Abstract

Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control.

Original language	English (US)
Pages (from-to)	1033-1037
Number of pages	5
Journal	DNA Repair
Volume	3
Issue number	8-9
DOIs	https://doi.org/10.1016/j.dnarep.2004.03.001
State	Published - Aug 2004
Externally published	Yes

Keywords

Checkpoint kinase
Claspin
DNA replication

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.dnarep.2004.03.001

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title = "Claspin, a regulator of Chk1 in DNA replication stress pathway",

abstract = "Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control.",

keywords = "Checkpoint kinase, Claspin, DNA replication",

author = "Chini, {Claudia C.S.} and Junjie Chen",

note = "Funding Information: We thank Carolin Merkle and Katherine Minter-Dykhouse for proof reading of this manuscript. This work is supported in part by grants from the National Institute of Health (CA89239 and CA92312) and the Breast Cancer Research Foundation. JC is a recipient of the DOD Breast Cancer Career Development Award (DAMD17-02-1-0472).",

year = "2004",

month = aug,

doi = "10.1016/j.dnarep.2004.03.001",

language = "English (US)",

volume = "3",

pages = "1033--1037",

journal = "DNA Repair",

issn = "1568-7864",

publisher = "Elsevier",

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}

TY - JOUR

T1 - Claspin, a regulator of Chk1 in DNA replication stress pathway

AU - Chini, Claudia C.S.

AU - Chen, Junjie

N1 - Funding Information: We thank Carolin Merkle and Katherine Minter-Dykhouse for proof reading of this manuscript. This work is supported in part by grants from the National Institute of Health (CA89239 and CA92312) and the Breast Cancer Research Foundation. JC is a recipient of the DOD Breast Cancer Career Development Award (DAMD17-02-1-0472).

PY - 2004/8

Y1 - 2004/8

N2 - Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control.

AB - Regulation of the vertebrate checkpoint kinase Chk1 involves several protein complexes including the recently identified protein Claspin. Claspin associates with Chk1 upon replication stress and DNA damage and is required for Chk1 activation in both Xenopus and human systems. More importantly, Claspin is involved in regulation of cell cycle checkpoints. Here, we discuss the emerging roles of Claspin in the Chk1 pathway and its functions in checkpoint control.

KW - Checkpoint kinase

KW - Claspin

KW - DNA replication

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DO - 10.1016/j.dnarep.2004.03.001

M3 - Review article

C2 - 15279790

AN - SCOPUS:3242878502

SN - 1568-7864

VL - 3

SP - 1033

EP - 1037

JO - DNA Repair

JF - DNA Repair

IS - 8-9

ER -

Claspin, a regulator of Chk1 in DNA replication stress pathway

Abstract

Keywords

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