Detecting transcriptionally active regions using genomic tiling arrays

Gabor Halasz; Marinus F. van Batenburg; Joelle Perusse; Sujun Hua; Xiang Jun Lu; Kevin P. White; Harmen J. Bussemaker

doi:10.1186/gb-2006-7-7-r59

Detecting transcriptionally active regions using genomic tiling arrays

Gabor Halasz, Marinus F. van Batenburg, Joelle Perusse, Sujun Hua, Xiang Jun Lu, Kevin P. White, Harmen J. Bussemaker

Genomic Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We have developed a method for interpreting genomic tiling array data, implemented as the program TranscriptionDetector. Probed loci expressed above background are identified by combining replicates in a way that makes minimal assumptions about the data. We performed medium-resolution Anopheles gambiae tiling array experiments and found extensive transcription of both coding and non-coding regions. Our method also showed improved detection of transcriptional units when applied to high-density tiling array data for ten human chromosomes.

Original language	English (US)
Article number	R59
Journal	Genome biology
Volume	7
Issue number	7
DOIs	https://doi.org/10.1186/gb-2006-7-7-r59
State	Published - Jul 19 2006

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Cell Biology

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10.1186/gb-2006-7-7-r59

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AU - Perusse, Joelle

AU - Hua, Sujun

AU - Lu, Xiang Jun

AU - White, Kevin P.

AU - Bussemaker, Harmen J.

PY - 2006/7/19

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AB - We have developed a method for interpreting genomic tiling array data, implemented as the program TranscriptionDetector. Probed loci expressed above background are identified by combining replicates in a way that makes minimal assumptions about the data. We performed medium-resolution Anopheles gambiae tiling array experiments and found extensive transcription of both coding and non-coding regions. Our method also showed improved detection of transcriptional units when applied to high-density tiling array data for ten human chromosomes.

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Detecting transcriptionally active regions using genomic tiling arrays

Abstract

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